Soft tissue sarcoma | Gene-Disease Associations & Pathways | GeDiPNet

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Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
soft tissue sarcoma	MONDO_0018078	PIK3CA	Unknown	26373574	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3R1	Unknown	26373574	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +150 more
		PPM1D	Unknown	28481359	Open Targets	p53 signaling pathway Transcriptional regulation by RUNX2
		PTCH1	Unknown	26373574	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTEN	Unknown	28481359 11349153	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPRD	Unknown	28481359	Open Targets	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
		RB1	Unknown	28481359	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		ROS1	Unknown	28481359	Open Targets	—
		SH2B3	Unknown	28481359	Open Targets	Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
		SMARCB1	Unknown	25651469	Open Targets	ATP-dependent chromatin remodeling Viral life cycle - HIV-1 Thermogenesis +3 more
		SOX2	Unknown	28481359	Open Targets	Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation +4 more
		SPEN	Unknown	28481359	Open Targets	Notch signaling pathway
		SS18	Unknown	9785009 17895746 10396284 11826189	Open Targets	ATP-dependent chromatin remodeling Transcriptional misregulation in cancer
		SSX1	Unknown	9785009 17895746 10396284 11826189	Open Targets	Transcriptional misregulation in cancer
		SSX2	Unknown	9785009 17895746 10396284 11826189	Open Targets	Transcriptional misregulation in cancer
		TERT	Unknown	28481359	Open Targets	Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer +4 more
		TP53	Unknown	31893257 9269965 25695693 8306343 11308256 27566247 8387391 26373574 28481359 28862265	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TSHR	Unknown	32291395	Open Targets	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +6 more
		WT1	Unknown	7530783	Open Targets	Transcriptional misregulation in cancer

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