Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
soft tissue sarcoma	MONDO_0018078	ARID2	Unknown	28481359	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		ATF1	Unknown	11064357	Open Targets	Aldosterone synthesis and secretion Transcriptional misregulation in cancer CREB phosphorylation +1 more
		ATRX	Unknown	28481359	Open Targets	Cell cycle
		BCORL1	Unknown	33020650	Open Targets	Polycomb repressive complex
		BRAF	Unknown	26373574 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BRCA2	Unknown	28481359	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		CDH1	Unknown	32291395	Open Targets	Rap1 signaling pathway Apelin signaling pathway Hippo signaling pathway +15 more
		CDK12	Unknown	28481359	Open Targets	TP53 Regulates Transcription of DNA Repair Genes
		CDKN2A	Unknown	28481359 8603340 9563903	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CIC	Unknown	28481359	Open Targets	Spinocerebellar ataxia
		CREB3L1	Unknown	16931951	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway PI3K-Akt signaling pathway +32 more
		CREB3L2	Unknown	15139001 16931951	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway PI3K-Akt signaling pathway +32 more
		CSF1R	Unknown	25695693	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +10 more
		CTNNB1	Unknown	39037077 28481359	Open Targets	Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway +51 more
		DDIT3	Unknown	8523819	Open Targets	MAPK signaling pathway Protein processing in endoplasmic reticulum Apoptosis +9 more
		DICER1	Unknown	31893257 26928971 31900434 27036314 28862265 32291395	Open Targets	MicroRNAs in cancer MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
		EED	Unknown	28481359	Open Targets	Polycomb repressive complex PRC2 methylates histones and DNA Oxidative Stress Induced Senescence +4 more
		EGFR	Unknown	23139256	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Virion - Hepatitis viruses +79 more
		EIF4A2	Unknown	28481359	Open Targets	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA +4 more
		EPHA7	Unknown	28481359	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		ERCC2	Unknown	28481359	Open Targets	Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex +19 more
		ERG	Unknown	7530783 11064357	Open Targets	Transcriptional misregulation in cancer Prostate cancer
		ETV4	Unknown	32291395	Open Targets	Transcriptional misregulation in cancer MAPK6/MAPK4 signaling
		ETV6	Unknown	17895746 10658907	Open Targets	Transcriptional misregulation in cancer Signaling by membrane-tethered fusions of PDGFRA or PDGFRB
		EWSR1	Unknown	7530783 11064357	Open Targets	Transcriptional misregulation in cancer
		FAT1	Unknown	28481359	Open Targets	—
		FBXW7	Unknown	27566247 25695693	Open Targets	Ubiquitin mediated proteolysis Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling +3 more
		FGFR1	Unknown	26373574	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +32 more
		FGFR3	Unknown	26373574	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +27 more
		FLI1	Unknown	7530783 11064357	Open Targets	Transcriptional misregulation in cancer
		FLT3	Unknown	28481359	Open Targets	MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway +8 more
		FOXO1	Unknown	7530783	Open Targets	FoxO signaling pathway AMPK signaling pathway Longevity regulating pathway +23 more
		FUS	Unknown	15139001 16931951 8523819	Open Targets	mRNA surveillance pathway Spliceosome Amyotrophic lateral sclerosis +3 more
		H3C2	Unknown	31645348	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +27 more
		HLA-A	Unknown	29901569 28481359	Open Targets	Endocytosis Phagosome Cellular senescence +25 more
		HNF1A	Unknown	28481359	Open Targets	Maturity onset diabetes of the young
		HRAS	Unknown	10812008	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		JAZF1	Unknown	18722875	Open Targets	—
		KDM6A	Unknown	28481359	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KDR	Unknown	33020650 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +13 more
		KMT2A	Unknown	29901569	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		LRP1B	Unknown	27566247	Open Targets	—
		MET	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MPL	Unknown	32291395	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling JAK-STAT signaling pathway
		NCOR1	Unknown	28481359	Open Targets	Endocrine resistance TGF-beta signaling pathway Thyroid hormone signaling pathway +16 more
		NRAS	Unknown	8453633	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NTRK3	Unknown	17895746 10658907	Open Targets	Calcium signaling pathway Neurotrophin signaling pathway Central carbon metabolism in cancer +4 more
		PALB2	Unknown	28481359	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +3 more
		PAX3	Unknown	7530783	Open Targets	Transcriptional misregulation in cancer HATs acetylate histones
		PAX7	Unknown	7530783	Open Targets	Transcriptional misregulation in cancer

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Soft tissue sarcoma

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