Skin neoplasms

Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Interferon alpha/beta signaling +1 more

Estrogen-dependent gene expression Signaling by membrane-tethered fusions of PDGFRA or PDGFRB

Type I hemidesmosome assembly Keratinization Formation of the cornified envelope

Neuroactive ligand-receptor interaction Hormone signaling Melanogenesis Peptide ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production +3 more

Natural killer cell mediated cytotoxicity Kaposi sarcoma-associated herpesvirus infection Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

Mitophagy - animal Osteoclast differentiation Melanogenesis Pathways in cancer Transcriptional misregulation in cancer Melanoma SUMOylation of transcription factors +4 more

Focal adhesion Adherens junction Leukocyte transendothelial migration Regulation of actin cytoskeleton Motor proteins Shigellosis Salmonella infection Smooth Muscle Contraction +5 more

Melanin biosynthesis

Rap1 signaling pathway Endocytosis Axon guidance Hippo signaling pathway Tight junction Human papillomavirus infection Tight junction interactions +4 more

Peroxisome Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes

Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation +3 more

Rho GTPase cycle Interleukin-4 and Interleukin-13 signaling

Glutamatergic synapse Neurexins and neuroligins

Cation-coupled Chloride cotransporters Defective SLC12A1 causes Bartter syndrome 1 (BS1)

Sodium/Calcium exchangers Defective SLC24A5 causes oculocutaneous albinism 6 (OCA6)

Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes

Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer Hepatocellular carcinoma Gastric cancer Telomere Extension By Telomerase Formation of the beta-catenin:TCF transactivating complex +4 more

NF-kappa B signaling pathway Necroptosis Toll-like receptor signaling pathway NOD-like receptor signaling pathway Alcoholic liver disease Pertussis Yersinia infection Chagas disease Hepatitis C Hepatitis B Influenza A Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection PD-L1 expression and PD-1 checkpoint pathway in cancer Lipid and atherosclerosis Caspase activation via Death Receptors in the presence of ligand MyD88-independent TLR4 cascade Toll Like Receptor 3 (TLR3) Cascade TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TICAM1 deficiency - HSE TRAF3 deficiency - HSE TLR3-mediated TICAM1-dependent programmed cell death TICAM1-dependent activation of IRF3/IRF7 TICAM1,TRAF6-dependent induction of TAK1 complex Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation +28 more

Calcium signaling pathway Pancreatic secretion Stimuli-sensing channels

Interferon gamma signaling

Cell cycle Human immunodeficiency virus 1 infection Polo-like kinase mediated events Cyclin E associated events during G1/S transition Cyclin A/B1/B2 associated events during G2/M transition G2/M DNA replication checkpoint Cyclin A:Cdk2-associated events at S phase entry Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex +5 more

Cobalamin transport and metabolism RNA polymerase II transcribes snRNA genes RNA Polymerase III Transcription Initiation From Type 3 Promoter

Ubiquitin mediated proteolysis Primary immunodeficiency

EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance MAPK signaling pathway ErbB signaling pathway Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway HIF-1 signaling pathway FoxO signaling pathway Sphingolipid signaling pathway Phospholipase D signaling pathway Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Apoptosis Longevity regulating pathway Longevity regulating pathway - multiple species Cellular senescence Adrenergic signaling in cardiomyocytes VEGF signaling pathway Apelin signaling pathway Osteoclast differentiation Focal adhesion Signaling pathways regulating pluripotency of stem cells Platelet activation Neutrophil extracellular trap formation Toll-like receptor signaling pathway C-type lectin receptor signaling pathway JAK-STAT signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis TNF signaling pathway Neurotrophin signaling pathway Cholinergic synapse Dopaminergic synapse Regulation of actin cytoskeleton Insulin signaling pathway Progesterone-mediated oocyte maturation Estrogen signaling pathway Prolactin signaling pathway Thyroid hormone signaling pathway Adipocytokine signaling pathway Glucagon signaling pathway Regulation of lipolysis in adipocytes Relaxin signaling pathway GnRH secretion Insulin resistance Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Alcoholic liver disease Carbohydrate digestion and absorption Alzheimer disease Spinocerebellar ataxia Shigellosis Salmonella infection Yersinia infection Chagas disease Toxoplasmosis Tuberculosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer Proteoglycans in cancer Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Glioma Prostate cancer Melanoma Chronic myeloid leukemia Acute myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation mTOR signalling AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network eNOS activation AKT-mediated inactivation of FOXO1A Integrin signaling Deactivation of the beta-catenin transactivating complex CD28 dependent PI3K/Akt signaling CTLA4 inhibitory signaling G beta:gamma signalling through PI3Kgamma Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RAB GEFs exchange GTP for GDP on RABs Regulation of PTEN stability and activity Extra-nuclear estrogen signaling Negative regulation of NOTCH4 signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling +131 more

Vasopressin-regulated water reabsorption Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins

Melanogenesis

Apoptosis RIG-I-like receptor signaling pathway TNF signaling pathway Tuberculosis Hepatitis B TP53 Regulates Transcription of Caspase Activators and Caspases FasL/ CD95L signaling TRAIL signaling NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 +6 more

Non-alcoholic fatty liver disease Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of granulopoiesis +3 more

Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway Hematopoietic cell lineage IL-17 signaling pathway Malaria Coronavirus disease - COVID-19 Other interleukin signaling Interleukin-10 signaling +6 more

Ribosome biogenesis in eukaryotes NF-kappa B signaling pathway Mitophagy - animal Wnt signaling pathway Adherens junction Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Measles PD-L1 expression and PD-1 checkpoint pathway in cancer Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity +16 more

Ribosome biogenesis in eukaryotes NF-kappa B signaling pathway Mitophagy - animal Wnt signaling pathway Adherens junction Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Measles PD-L1 expression and PD-1 checkpoint pathway in cancer Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity +16 more

Ribosome biogenesis in eukaryotes Polycomb repressive complex NF-kappa B signaling pathway Mitophagy - animal Wnt signaling pathway Adherens junction Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Measles PD-L1 expression and PD-1 checkpoint pathway in cancer Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Neutrophil degranulation Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity +18 more