Signet ring cell gastric adenocarcinoma | Gene-Disease Associations & Pathways | GeDiPNet

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Subtype of: Gastric cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
signet ring cell gastric adenocarcinoma	MONDO_0006409	PIK3CA	Unknown	29420467	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PML	Unknown	28978722	Open Targets	Ubiquitin mediated proteolysis Endocytosis Influenza A +12 more
		POLE	Unknown	29420467	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		PRDM16	Unknown	28978722	Open Targets	Lysine degradation Metabolic pathways Thermogenesis +1 more
		PRF1	Unknown	28978722	Open Targets	Apoptosis Natural killer cell mediated cytotoxicity Type I diabetes mellitus +4 more
		PTEN	Unknown	15633233	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPRC	Unknown	28978722	Open Targets	Cell adhesion molecules T cell receptor signaling pathway Fc gamma R-mediated phagocytosis +5 more
		PTPRD	Unknown	28978722 29420467	Open Targets	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
		RARA	Unknown	28978722	Open Targets	Th17 cell differentiation Estrogen signaling pathway Pathways in cancer +6 more
		RECQL4	Unknown	28978722	Open Targets	—
		RHOA	Unknown	28978722	Open Targets	Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway +64 more
		RNF213	Unknown	28978722	Open Targets	Suppression of apoptosis Antigen processing: Ubiquitination & Proteasome degradation
		ROS1	Unknown	23400546	Open Targets	—
		SDC4	Unknown	23400546	Open Targets	ECM-receptor interaction Cell adhesion molecules Cytoskeleton in muscle cells +13 more
		SFRP4	Unknown	28978722	Open Targets	Wnt signaling pathway
		SLC34A2	Unknown	23400546	Open Targets	Parathyroid hormone synthesis, secretion and action Mineral absorption Type II Na+/Pi cotransporters +2 more
		SMAD2	Unknown	28978722	Open Targets	Cell cycle Endocytosis Cellular senescence +30 more
		SMAD3	Unknown	28978722	Open Targets	FoxO signaling pathway Cell cycle Endocytosis +34 more
		SMAD4	Unknown	29420467	Open Targets	FoxO signaling pathway Hormone signaling Cell cycle +30 more
		SPEN	Unknown	29420467	Open Targets	Notch signaling pathway
		STAT3	Unknown	28978722	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway HIF-1 signaling pathway +53 more
		SUZ12	Unknown	28978722	Open Targets	Polycomb repressive complex PRC2 methylates histones and DNA Oxidative Stress Induced Senescence +5 more
		TCF3	Unknown	28978722	Open Targets	Signaling pathways regulating pluripotency of stem cells Human T-cell leukemia virus 1 infection Transcriptional misregulation in cancer +2 more
		TFE3	Unknown	28978722	Open Targets	Mitophagy - animal Transcriptional misregulation in cancer Renal cell carcinoma
		TNRC18	Unknown	28978722	Open Targets	—
		TOP1	Unknown	28978722	Open Targets	SUMOylation of DNA replication proteins
		TP53	Unknown	32727394 21573592 28978722 11846063 7674088 38459566 29420467	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TPM3	Unknown	23400546	Open Targets	Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Motor proteins +7 more
		WT1	Unknown	28978722	Open Targets	Transcriptional misregulation in cancer
		ZEB1	Unknown	28978722	Open Targets	Transcriptional misregulation in cancer MicroRNAs in cancer Prostate cancer +1 more
		ZFHX3	Unknown	29420467	Open Targets	Signaling pathways regulating pluripotency of stem cells RUNX3 regulates CDKN1A transcription

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