Subtype of: Gastric cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
signet ring cell gastric adenocarcinoma	MONDO_0006409	ABL2	Unknown	28978722	Open Targets	ErbB signaling pathway Ras signaling pathway Chemical carcinogenesis - reactive oxygen species +2 more
		AFF3	Unknown	28978722	Open Targets	—
		APC	Unknown	1317264 7674088	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		ARID1A	Unknown	32727394 28481359	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ASPM	Unknown	28978722	Open Targets	—
		ASPSCR1	Unknown	28978722	Open Targets	Transcriptional misregulation in cancer
		ASXL2	Unknown	28481359	Open Targets	Polycomb repressive complex UCH proteinases
		BAP1	Unknown	28978722	Open Targets	Polycomb repressive complex UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
		CBLB	Unknown	28978722	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +5 more
		CD74	Unknown	23400546	Open Targets	Antigen processing and presentation Tuberculosis Herpes simplex virus 1 infection +2 more
		CDH1	Unknown	32727394 11058874 28978722 9045944 22152101 8797891 29420467 28481359	Open Targets	Rap1 signaling pathway Apelin signaling pathway Hippo signaling pathway +15 more
		CDH10	Unknown	28978722	Open Targets	Adherens junctions interactions
		CDKN2A	Unknown	28978722 8797888	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CHD4	Unknown	28978722	Open Targets	ATP-dependent chromatin remodeling Human papillomavirus infection Viral carcinogenesis +5 more
		CSMD3	Unknown	28978722	Open Targets	—
		CTCF	Unknown	28481359	Open Targets	—
		CUX1	Unknown	28978722	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Intra-Golgi traffic
		DCC	Unknown	28978722	Open Targets	Axon guidance Pathways in cancer Colorectal cancer +3 more
		EED	Unknown	28978722	Open Targets	Polycomb repressive complex PRC2 methylates histones and DNA Oxidative Stress Induced Senescence +4 more
		ELF3	Unknown	28978722	Open Targets	Pre-NOTCH Transcription and Translation
		ERBB3	Unknown	29420467	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +19 more
		ERCC5	Unknown	28978722	Open Targets	Nucleotide excision repair Formation of Incision Complex in GG-NER Dual Incision in GG-NER +1 more
		EZR	Unknown	23400546	Open Targets	Tight junction Leukocyte transendothelial migration Regulation of actin cytoskeleton +6 more
		FAT1	Unknown	28481359	Open Targets	—
		FAT3	Unknown	28978722	Open Targets	—
		FBXO11	Unknown	28978722	Open Targets	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		FCGR2B	Unknown	28978722	Open Targets	Virion - Ebolavirus, Lyssavirus and Morbillivirus Phagosome Osteoclast differentiation +6 more
		FGFR2	Unknown	28978722	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +26 more
		FLNA	Unknown	28978722	Open Targets	MAPK signaling pathway Focal adhesion Salmonella infection +6 more
		FLT4	Unknown	28978722 29420467	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +6 more
		GRM3	Unknown	28978722	Open Targets	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +3 more
		ID3	Unknown	29420467	Open Targets	TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells NGF-stimulated transcription
		IKZF3	Unknown	28978722	Open Targets	—
		IL6ST	Unknown	28978722	Open Targets	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Signaling pathways regulating pluripotency of stem cells +12 more
		ITGAV	Unknown	28978722	Open Targets	Hormone signaling Phagosome Efferocytosis +26 more
		KDM6A	Unknown	28978722	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KMT2A	Unknown	28978722	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	19734198 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LASP1	Unknown	28978722	Open Targets	—
		LRIG3	Unknown	23400546	Open Targets	—
		MED12	Unknown	28978722	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MSH6	Unknown	28978722	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +4 more
		MUC16	Unknown	28978722	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC4	Unknown	28978722	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC6	Unknown	28978722	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MYB	Unknown	28978722	Open Targets	PI3K-Akt signaling pathway RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression
		NDRG1	Unknown	28978722	Open Targets	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
		NRG1	Unknown	28978722	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Amyotrophic lateral sclerosis +18 more
		NTRK1	Unknown	28978722	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +13 more
		NTRK3	Unknown	28978722	Open Targets	Calcium signaling pathway Neurotrophin signaling pathway Central carbon metabolism in cancer +4 more

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Signet ring cell gastric adenocarcinoma

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