Sickle cell anemia

Porphyrin metabolism Metabolic pathways Biosynthesis of cofactors Heme biosynthesis Neutrophil degranulation +2 more

Fat digestion and absorption Vitamin digestion and absorption Cholesterol metabolism Lipid and atherosclerosis Cell surface interactions at the vascular wall Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class H Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Platelet sensitization by LDL Regulation of TLR by endogenous ligand Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance LDL clearance LDL remodeling VLDL clearance Retinoid metabolism and transport +20 more

Neuroactive ligand-receptor interaction Phagosome Complement and coagulation cascades Neutrophil extracellular trap formation Alcoholic liver disease Shigellosis Pertussis Legionellosis Leishmaniasis Chagas disease Staphylococcus aureus infection Tuberculosis Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Coronavirus disease - COVID-19 Viral carcinogenesis Systemic lupus erythematosus Alternative complement activation Activation of C3 and C5 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Peptide ligand-binding receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (i) signalling events Neutrophil degranulation Post-translational protein phosphorylation Purinergic signaling in leishmaniasis infection Regulation of Complement cascade +24 more

Arginine biosynthesis Pyrimidine metabolism Alanine, aspartate and glutamate metabolism Metabolic pathways Biosynthesis of cofactors Pyrimidine biosynthesis +3 more

Complement and coagulation cascades Staphylococcus aureus infection Coronavirus disease - COVID-19 Alternative complement activation Activation of C3 and C5 Regulation of Complement cascade +3 more

Arachidonic acid metabolism Linoleic acid metabolism Drug metabolism - cytochrome P450 Metabolic pathways Serotonergic synapse Chemical carcinogenesis - DNA adducts Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) +7 more

Pyrimidine metabolism Metabolic pathways Biosynthesis of cofactors Pyrimidine biosynthesis +1 more

Folate biosynthesis Metabolic pathways Biosynthesis of cofactors Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation +1 more

Glutathione metabolism Metabolic pathways Thyroid hormone synthesis Amyotrophic lateral sclerosis Huntington disease Pathways of neurodegeneration - multiple diseases Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species Purine catabolism +7 more

Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Drug metabolism - other enzymes Metabolic pathways Platinum drug resistance Pathways in cancer Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Hepatocellular carcinoma Fluid shear stress and atherosclerosis Glutathione conjugation +10 more

African trypanosomiasis Malaria Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Scavenging of heme from plasma Neutrophil degranulation Factors involved in megakaryocyte development and platelet production +4 more

Factors involved in megakaryocyte development and platelet production

Factors involved in megakaryocyte development and platelet production

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling +28 more

Porphyrin metabolism Metabolic pathways Biosynthesis of cofactors Heme biosynthesis +1 more

Scavenging of heme from plasma Neutrophil degranulation

One carbon pool by folate Metabolic pathways Antifolate resistance Folate transport and metabolism Metabolism of folate and pterines +2 more

Protein processing in endoplasmic reticulum Parkinson disease Pathways in cancer Chemical carcinogenesis - reactive oxygen species Hepatocellular carcinoma Lipid and atherosclerosis Fluid shear stress and atherosclerosis +4 more

Arginine biosynthesis Arginine and proline metabolism Metabolic pathways Calcium signaling pathway cGMP-PKG signaling pathway HIF-1 signaling pathway Sphingolipid signaling pathway PI3K-Akt signaling pathway VEGF signaling pathway Apelin signaling pathway Platelet activation Estrogen signaling pathway Oxytocin signaling pathway Relaxin signaling pathway Insulin resistance AGE-RAGE signaling pathway in diabetic complications Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis ROS and RNS production in phagocytes Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation eNOS activation NOSTRIN mediated eNOS trafficking NOSIP mediated eNOS trafficking Nitric oxide stimulates guanylate cyclase VEGFR2 mediated vascular permeability Extra-nuclear estrogen signaling +24 more

cGMP-PKG signaling pathway Hormone signaling Vascular smooth muscle contraction Thermogenesis +1 more

Antifolate resistance MAPK signaling pathway Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor NF-kappa B signaling pathway Sphingolipid signaling pathway mTOR signaling pathway Apoptosis Necroptosis TGF-beta signaling pathway Osteoclast differentiation Antigen processing and presentation Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway C-type lectin receptor signaling pathway Hematopoietic cell lineage Natural killer cell mediated cytotoxicity IL-17 signaling pathway T cell receptor signaling pathway Fc epsilon RI signaling pathway TNF signaling pathway Adipocytokine signaling pathway Type II diabetes mellitus Insulin resistance Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Type I diabetes mellitus Alzheimer disease Amyotrophic lateral sclerosis Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Legionellosis Yersinia infection Leishmaniasis Chagas disease African trypanosomiasis Malaria Toxoplasmosis Amoebiasis Tuberculosis Hepatitis C Hepatitis B Human cytomegalovirus infection Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Proteoglycans in cancer Asthma Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Hypertrophic cardiomyopathy Dilated cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production TNFR2 non-canonical NF-kB pathway Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling TNF signaling +72 more

Pyrimidine metabolism Drug metabolism - other enzymes Metabolic pathways Biosynthesis of cofactors Pyrimidine biosynthesis +2 more

NF-kappa B signaling pathway Cell adhesion molecules TNF signaling pathway Leukocyte transendothelial migration AGE-RAGE signaling pathway in diabetic complications African trypanosomiasis Malaria Lipid and atherosclerosis Fluid shear stress and atherosclerosis Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling +10 more

African trypanosomiasis Malaria Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Scavenging of heme from plasma Neutrophil degranulation Factors involved in megakaryocyte development and platelet production +4 more

Factors involved in megakaryocyte development and platelet production

Factors involved in megakaryocyte development and platelet production

mTOR signaling pathway Amino acids regulate mTORC1

Olfactory transduction Olfactory Signaling Pathway

Olfactory transduction Olfactory Signaling Pathway

Olfactory transduction Olfactory Signaling Pathway