Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
rectum adenocarcinoma	MONDO_0002169	TNC	Unknown	22810696 33262464 29937994 26416732 31660073 30239619 26764183	Open Targets	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +6 more
		TNFAIP3	Unknown	28481359 25344691 31660073	Open Targets	NF-kappa B signaling pathway Necroptosis NOD-like receptor signaling pathway +10 more
		TNFRSF14	Unknown	33262464 28481359 31660073	Open Targets	Virion - Herpesvirus Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor +3 more
		TNFRSF17	Unknown	33262464 25957691 29937994	Open Targets	Cytokine-cytokine receptor interaction Intestinal immune network for IgA production TNFs bind their physiological receptors
		TNRC18	Unknown	22810696 30038269 33262464 27612425 26416732 31660073 24755471 26764183	Open Targets	—
		TOP1	Unknown	22810696 30038269 33262464 26416732 25957691 31660073 30239619 24755471 28481359	Open Targets	SUMOylation of DNA replication proteins
		TP53	Unknown	18602395 9823556 26650777 9851256 9036877 27612425 26416732 28120820 11592095 29316426 10328221 27121310 8267380 14688025 11241240 22261536 22178590 11275993 26134512 24755471 28461034 21726664 22810696 29967250 11406538 29069792 21103049 11231481 15492791 28145097 37262393 12093899 21458303 26109429 31660073 15057748 16959974 19794270 28915719 12115559 31400926 37391803 8033106 21901162 29937994 27247954 27756406 25957691 28465371 31226844 25344691 9052405 26764183 11923604 28551381 33262464 24470207 8317886 29438965 26536055 24841357 28978093 9470817 30239619 11317955 25617745 9030251 28481359 22493386	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TP63	Unknown	29316426 28481359 33262464	Open Targets	MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes +5 more
		TPM3	Unknown	22810696 26109429 26416732	Open Targets	Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Motor proteins +7 more
		TPM4	Unknown	22810696 33262464	Open Targets	Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Motor proteins +5 more
		TPR	Unknown	22810696 29967250 33262464 29937994 26416732 31660073 26109429 24755471	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Pathways in cancer +27 more
		TRAF7	Unknown	26416732 29316426 28481359	Open Targets	Antigen processing: Ubiquitination & Proteasome degradation
		TRIM24	Unknown	24755471 26416732 25344691 31660073	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF fusions
		TRIM27	Unknown	22810696 33262464 31660073	Open Targets	SUMOylation of ubiquitinylation proteins Regulation of PTEN stability and activity Suppression of apoptosis
		TRIM33	Unknown	22810696 24755471 26416732 33262464 29967250	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity
		TRIP11	Unknown	22810696 33262464 29967250	Open Targets	Intraflagellar transport Intra-Golgi traffic
		TRRAP	Unknown	22810696 30038269 33262464 29937994 26416732 25957691 31660073 25344691 24755471 26764183	Open Targets	ATP-dependent chromatin remodeling Human T-cell leukemia virus 1 infection Formation of the beta-catenin:TCF transactivating complex +1 more
		TSC1	Unknown	22810696 33262464 29937994 29316426 25957691 25344691 28481359	Open Targets	Phospholipase D signaling pathway Autophagy - animal mTOR signaling pathway +15 more
		TSC2	Unknown	29316426 26416732 33262464 28481359 31660073	Open Targets	Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal +19 more
		TSHR	Unknown	28481359 26416732 25344691	Open Targets	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +6 more
		U2AF1	Unknown	22810696 29316426 28481359	Open Targets	Spliceosome Shigellosis Transport of Mature mRNA derived from an Intron-Containing Transcript +3 more
		UBR5	Unknown	22810696 30038269 33262464 26416732 31660073 25344691	Open Targets	Ubiquitin mediated proteolysis
		USP44	Unknown	25344691 31660073	Open Targets	Ub-specific processing proteases
		USP6	Unknown	22810696 30038269 26416732 33262464 31660073	Open Targets	—
		USP8	Unknown	30239619 33262464	Open Targets	Mitophagy - animal Endocytosis Cushing syndrome +4 more
		USP9X	Unknown	22810696 26109429 26416732 33262464 31660073	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes +2 more
		VAV1	Unknown	33262464 25344691 31660073	Open Targets	Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway +30 more
		VHL	Unknown	27756406	Open Targets	HIF-1 signaling pathway Ubiquitin mediated proteolysis Pathways in cancer +5 more
		VTI1A	Unknown	33262464 25344691 31660073	Open Targets	SNARE interactions in vesicular transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
		WAS	Unknown	33262464	Open Targets	Chemokine signaling pathway Adherens junction Tight junction +7 more
		WDCP	Unknown	30239619 33262464	Open Targets	—
		WIF1	Unknown	24755471	Open Targets	Wnt signaling pathway
		WNK2	Unknown	22810696 33262464 26416732 31660073 25344691 24755471	Open Targets	Parathyroid hormone synthesis, secretion and action Stimuli-sensing channels
		WRN	Unknown	22810696 33262464 29967250	Open Targets	Processive synthesis on the C-strand of the telomere Removal of the Flap Intermediate from the C-strand SUMOylation of DNA damage response and repair proteins +9 more
		WT1	Unknown	28481359 33262464 25344691	Open Targets	Transcriptional misregulation in cancer
		WWTR1	Unknown	33262464	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo +5 more
		XPA	Unknown	33262464	Open Targets	Platinum drug resistance Nucleotide excision repair Formation of Incision Complex in GG-NER +3 more
		XPC	Unknown	22810696 33262464 27612425 31660073 25344691 24755471	Open Targets	Nucleotide excision repair SUMOylation of DNA damage response and repair proteins DNA Damage Recognition in GG-NER +1 more
		XPO1	Unknown	22810696 33262464 28465371 31660073 24755471 28481359	Open Targets	Ribosome biogenesis in eukaryotes Nucleocytoplasmic transport Viral life cycle - HIV-1 +15 more
		YAP1	Unknown	33262464 28481359	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Nuclear signaling by ERBB4 +5 more
		YWHAE	Unknown	33262464 31660073	Open Targets	Cell cycle Oocyte meiosis PI3K-Akt signaling pathway +22 more
		ZBTB16	Unknown	22810696 30038269	Open Targets	Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia +2 more
		ZCCHC8	Unknown	22810696 27612425	Open Targets	—
		ZEB1	Unknown	26109429 29937994 27612425	Open Targets	Transcriptional misregulation in cancer MicroRNAs in cancer Prostate cancer +1 more
		ZFHX3	Unknown	22810696 33262464 27612425 29937994 29316426 31660073 25344691 24755471 26764183 28481359	Open Targets	Signaling pathways regulating pluripotency of stem cells RUNX3 regulates CDKN1A transcription
		ZMYM2	Unknown	22810696 26416732 33262464 31660073	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease
		ZMYM3	Unknown	25344691 31660073	Open Targets	—
		ZNF331	Unknown	22810696 30239619 33262464 31660073	Open Targets	Generic Transcription Pathway
		ZNF384	Unknown	33262464	Open Targets	—
		ZNF429	Unknown	22810696 24755471 25344691 31660073	Open Targets	Generic Transcription Pathway

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Rectum adenocarcinoma

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