Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
rectum adenocarcinoma	MONDO_0002169	SND1	Unknown	22810696 26416732 33262464 25344691 31660073	Open Targets	Viral carcinogenesis Signaling by BRAF and RAF fusions
		SNX29	Unknown	22810696 26416732 33262464 31660073	Open Targets	—
		SOCS1	Unknown	28481359 31660073	Open Targets	Ubiquitin mediated proteolysis Osteoclast differentiation JAK-STAT signaling pathway +13 more
		SOS1	Unknown	26109429 26416732 33262464 31660073	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +97 more
		SOX2	Unknown	29967250 28481359	Open Targets	Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation +4 more
		SOX21	Unknown	33262464	Open Targets	—
		SPECC1	Unknown	22810696 24755471 33262464 26764183 29937994	Open Targets	—
		SPEN	Unknown	22810696 29967250 33262464 27612425 29937994 29316426 25344691 24755471 28481359	Open Targets	Notch signaling pathway
		SPOP	Unknown	27612425 28481359 31660073	Open Targets	Hedgehog signaling pathway Hedgehog 'on' state
		SRC	Unknown	29316426 33262464 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +92 more
		SRGAP3	Unknown	22810696 30038269 26416732 33262464 31660073	Open Targets	Axon guidance Rho GTPase cycle
		SRSF2	Unknown	28481359	Open Targets	Spliceosome Herpes simplex virus 1 infection Transport of Mature mRNA derived from an Intron-Containing Transcript +4 more
		SRSF3	Unknown	29937994 31660073	Open Targets	Spliceosome Amyotrophic lateral sclerosis Herpes simplex virus 1 infection +4 more
		SS18L1	Unknown	22810696 31660073	Open Targets	ATP-dependent chromatin remodeling Transcriptional misregulation in cancer
		SSX1	Unknown	22810696 33262464	Open Targets	Transcriptional misregulation in cancer
		STAG1	Unknown	22810696 31660073 26416732 33262464 29937994	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		STAG2	Unknown	22810696 33262464 26416732 31660073 30239619 28481359	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		STAT3	Unknown	29316426 23317146 33262464 28481359 31660073	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway HIF-1 signaling pathway +53 more
		STAT5B	Unknown	33262464 25344691 26764183	Open Targets	ErbB signaling pathway Chemokine signaling pathway Hormone signaling +28 more
		STAT6	Unknown	33262464 29937994	Open Targets	Necroptosis JAK-STAT signaling pathway Th1 and Th2 cell differentiation +7 more
		STIL	Unknown	22810696 25344691	Open Targets	—
		STK11	Unknown	26416732 29316426 27756406 31660073 9731485 28481359	Open Targets	FoxO signaling pathway Hormone signaling Autophagy - animal +9 more
		STRN	Unknown	22810696 26416732 33262464 29937994 31660073	Open Targets	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling +2 more
		SUFU	Unknown	28481359 33262464 25344691	Open Targets	Hedgehog signaling pathway Pathways in cancer Basal cell carcinoma +4 more
		SUZ12	Unknown	22810696 33262464 26109429 25344691 24755471 28481359	Open Targets	Polycomb repressive complex PRC2 methylates histones and DNA Oxidative Stress Induced Senescence +5 more
		SYK	Unknown	22810696 33262464 29316426 31660073 25344691 26764183	Open Targets	NF-kappa B signaling pathway Phospholipase D signaling pathway PI3K-Akt signaling pathway +30 more
		TAL1	Unknown	33262464	Open Targets	RUNX1 regulates transcription of genes involved in differentiation of HSCs
		TBL1XR1	Unknown	26416732 33262464 31660073	Open Targets	Wnt signaling pathway RORA activates gene expression PPARA activates gene expression +11 more
		TBX3	Unknown	22810696 33262464 28481359 29316426	Open Targets	Signaling pathways regulating pluripotency of stem cells
		TCEA1	Unknown	22810696 26416732 30239619	Open Targets	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex +5 more
		TCF12	Unknown	33262464 25344691 31660073	Open Targets	Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs NGF-stimulated transcription
		TCF3	Unknown	29316426 26764183 31660073	Open Targets	Signaling pathways regulating pluripotency of stem cells Human T-cell leukemia virus 1 infection Transcriptional misregulation in cancer +2 more
		TCF7L2	Unknown	22810696 29967250 33262464 29937994 26416732 28120820 29316426 25957691 31660073 26109429 28978093 25344691 24755471 26764183 28481359	Open Targets	Wnt signaling pathway Hippo signaling pathway Adherens junction +26 more
		TCL1A	Unknown	26416732 31660073	Open Targets	PI3K-Akt signaling pathway
		TEC	Unknown	22810696 33262464 25344691 31660073	Open Targets	Osteoclast differentiation T cell receptor signaling pathway Signaling by SCF-KIT +2 more
		TENT5C	Unknown	29316426 33262464 28481359 29937994	Open Targets	—
		TERT	Unknown	30038269 33262464 31660073 30239619 25344691 28481359	Open Targets	Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer +4 more
		TET1	Unknown	22810696 24755471 29316426 28481359 33262464	Open Targets	—
		TET2	Unknown	29967250 30038269 22810696 26416732 29316426 28465371 31660073 28481359	Open Targets	—
		TFE3	Unknown	29967250 24755471 33262464 31660073	Open Targets	Mitophagy - animal Transcriptional misregulation in cancer Renal cell carcinoma
		TFEB	Unknown	26416732 33262464	Open Targets	Calcium signaling pathway Mitophagy - animal
		TFG	Unknown	31660073	Open Targets	Pathways in cancer Thyroid cancer COPII-mediated vesicle transport
		TFPT	Unknown	30038269	Open Targets	ATP-dependent chromatin remodeling UCH proteinases DNA Damage Recognition in GG-NER
		TFRC	Unknown	22810696 26416732	Open Targets	Virion - Lassa virus and SFTS virus HIF-1 signaling pathway Endocytosis +8 more
		TGFBR2	Unknown	8978340 20979647 33262464 26416732 29316426 31660073 28978093 19503063 8840968 28481359	Open Targets	MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway +28 more
		THRAP3	Unknown	30038269 26416732	Open Targets	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation
		TLX1	Unknown	22810696 24755471 25344691	Open Targets	Transcriptional misregulation in cancer
		TLX3	Unknown	26416732 33262464 25344691	Open Targets	Transcriptional misregulation in cancer
		TMEM127	Unknown	25344691 28481359	Open Targets	—
		TMSB4X	Unknown	33262464	Open Targets	Regulation of actin cytoskeleton Platelet degranulation

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Rectum adenocarcinoma

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