Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
rectum adenocarcinoma	MONDO_0002169	ABI1	Unknown	33262464 31660073	Open Targets	Pathogenic Escherichia coli infection Salmonella infection Regulation of actin dynamics for phagocytic cup formation +3 more
		ABL1	Unknown	33262464 26416732 29316426 27756406 25344691 25617745 26764183 28481359	Open Targets	ErbB signaling pathway Ras signaling pathway Cell cycle +17 more
		ABL2	Unknown	33262464	Open Targets	ErbB signaling pathway Ras signaling pathway Chemical carcinogenesis - reactive oxygen species +2 more
		ACKR3	Unknown	33262464	Open Targets	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine receptors bind chemokines +1 more
		ACSL3	Unknown	26416732 33262464 31660073	Open Targets	Fatty acid biosynthesis Fatty acid degradation Metabolic pathways +8 more
		ACSL6	Unknown	33262464 31660073	Open Targets	Fatty acid biosynthesis Fatty acid degradation Metabolic pathways +7 more
		ACVR1	Unknown	29316426 28481359 31660073	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling TGF-beta signaling pathway +2 more
		ACVR1B	Unknown	30038269 33262464 26416732 31660073 28978093 30239619 25344691 26764183	Open Targets	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells +1 more
		ACVR2A	Unknown	29967250 33262464 27612425 29937994 26416732 28978093 19503063 25344691	Open Targets	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells +3 more
		AFDN	Unknown	27612425 24755471 33262464 25344691 31660073	Open Targets	Ras signaling pathway Rap1 signaling pathway cAMP signaling pathway +4 more
		AFF1	Unknown	22810696 26416732 33262464 31660073	Open Targets	Transcriptional misregulation in cancer
		AFF3	Unknown	22810696 26416732 33262464 25344691 31660073	Open Targets	—
		AFF4	Unknown	26416732 33262464 25344691 31660073	Open Targets	Viral life cycle - HIV-1 Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events +1 more
		AKAP9	Unknown	22810696 33262464 29937994 26109429 30239619 25344691 24755471	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +7 more
		AKT1	Unknown	30038269 27612425 26416732 27121310 31660073 26968814 27155048 28481359 21726664	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +131 more
		AKT2	Unknown	22810696 33262464 26416732 31660073 25344691 24755471 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +122 more
		AKT3	Unknown	29967250 33262464 26416732 30239619 24755471 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +119 more
		ALDH2	Unknown	33262464	Open Targets	Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Fatty acid degradation +14 more
		ALK	Unknown	29967250 30038269 33262464 26416732 29316426 27247954 31660073 25344691 24755471 28481359	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		AMER1	Unknown	18720004 22810696 29967250 33262464 30038269 29937994 26416732 29316426 28120820 31660073 28978093 26109429 30239619 25344691 24755471 28481359 28551381	Open Targets	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane +8 more
		ANK1	Unknown	33262464 25344691 31660073	Open Targets	Proteoglycans in cancer Interaction between L1 and Ankyrins Neurofascin interactions +1 more
		APC	Unknown	18602395 26650777 30038269 27612425 26416732 29316426 28120820 27121310 26134512 8081386 24755471 17932254 11821507 22810696 29967250 29069792 37262393 31660073 36212424 26109429 22287596 16959974 28915719 20544848 31400926 20951698 9260769 21901162 21837511 16258065 29937994 10737795 19679059 27756406 28465371 11746989 19527492 25957691 25344691 22864938 18977219 26764183 20176655 28551381 8895682 33262464 19026650 24470207 29438965 28978093 30239619 28548127 9330602 25617745 26536055 28481359 31226844	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		APOBEC3B	Unknown	29937994	Open Targets	Viral life cycle - HIV-1 Human immunodeficiency virus 1 infection mRNA Editing: C to U Conversion +1 more
		AR	Unknown	22810696 30038269 29967250 33262464 26416732 29316426 31660073 28481359	Open Targets	Oocyte meiosis Pathways in cancer Chemical carcinogenesis - receptor activation +7 more
		ARAF	Unknown	22810696 33262464 29937994 26109429 30239619 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +41 more
		ARHGAP26	Unknown	33262464 31660073	Open Targets	Rho GTPase cycle
		ARHGAP35	Unknown	22810696 33262464	Open Targets	Focal adhesion Platelet activation Leukocyte transendothelial migration +4 more
		ARHGAP5	Unknown	22810696 33262464	Open Targets	Focal adhesion Leukocyte transendothelial migration Rho GTPase cycle
		ARHGEF10	Unknown	22810696 26416732 31660073 30239619 25344691 24755471	Open Targets	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
		ARHGEF10L	Unknown	22810696 25344691 31660073	Open Targets	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
		ARHGEF12	Unknown	22810696 26416732 25957691	Open Targets	Vascular smooth muscle contraction Axon guidance Platelet activation +12 more
		ARID1A	Unknown	29967250 22810696 30038269 24943349 33262464 29937994 26416732 29316426 28465371 37262393 31660073 24841357 25344691 25617745 26764183 28481359	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID1B	Unknown	30038269 33262464 29937994 26416732 29316426 25344691 28481359	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID2	Unknown	22810696 30038269 29967250 33262464 27612425 24382590 29316426 31660073 28481359	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		ARNT	Unknown	33262464 25344691 29937994 31660073	Open Targets	HIF-1 signaling pathway Efferocytosis Cushing syndrome +10 more
		ASPM	Unknown	22810696 33262464 29937994 26416732 25957691 31660073 30239619 24755471 26764183	Open Targets	—
		ASPSCR1	Unknown	26416732 33262464 31660073	Open Targets	Transcriptional misregulation in cancer
		ASXL1	Unknown	22810696 33262464 29937994 26416732 29316426 25344691 24755471 28481359	Open Targets	Polycomb repressive complex UCH proteinases
		ASXL2	Unknown	22810696 33262464 27612425 29937994 26416732 31660073 30239619 24755471 28481359	Open Targets	Polycomb repressive complex UCH proteinases
		ATF1	Unknown	22810696 27612425	Open Targets	Aldosterone synthesis and secretion Transcriptional misregulation in cancer CREB phosphorylation +1 more
		ATIC	Unknown	24755471 33262464 31660073	Open Targets	Purine metabolism One carbon pool by folate Metabolic pathways +2 more
		ATM	Unknown	29967250 22810696 26650777 33262464 30038269 29937994 36552003 26416732 29316426 27756406 28465371 25957691 31660073 28978093 24755471 31400926 28481359	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		ATP1A1	Unknown	24755471 26416732 30038269 31660073	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway Cardiac muscle contraction +18 more
		ATP2B3	Unknown	26416732 33262464 31660073	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +9 more
		ATR	Unknown	22810696 33262464 26416732 25344691 28915719 28481359	Open Targets	Fanconi anemia pathway Cell cycle p53 signaling pathway +13 more
		ATRX	Unknown	29967250 33262464 29937994 26416732 29316426 28465371 31660073 25344691 24755471 28481359	Open Targets	Cell cycle
		AXIN1	Unknown	22810696 33262464 26416732 29316426 11746989 31660073 24755471 28481359	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		AXIN2	Unknown	22810696 33262464 27612425 29937994 26416732 29316426 31660073 28978093 21541676 25344691 24755471 28481359	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +15 more
		B2M	Unknown	22810696 33262464 29316426 31660073 25344691 24755471 28481359	Open Targets	Antigen processing and presentation Human cytomegalovirus infection Human T-cell leukemia virus 1 infection +14 more
		BAP1	Unknown	30239619 29316426 31660073	Open Targets	Polycomb repressive complex UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

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Rectum adenocarcinoma

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