Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
rectum adenocarcinoma	MONDO_0002169	CCNE1	Unknown	22810696 25344691	Open Targets	Cell cycle Oocyte meiosis p53 signaling pathway +24 more
		CCR4	Unknown	22810696	Open Targets	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +4 more
		CCR7	Unknown	22810696 26416732	Open Targets	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +2 more
		CD209	Unknown	33262464 25344691	Open Targets	Virion - Human immunodeficiency virus Virion - Flavivirus and Alphavirus Virion - Ebolavirus, Lyssavirus and Morbillivirus +7 more
		CD274	Unknown	24755471 28481359	Open Targets	Cell adhesion molecules PD-L1 expression and PD-1 checkpoint pathway in cancer PD-1 signaling
		CD28	Unknown	31660073	Open Targets	Cell adhesion molecules T cell receptor signaling pathway Intestinal immune network for IgA production +16 more
		CD74	Unknown	31660073	Open Targets	Antigen processing and presentation Tuberculosis Herpes simplex virus 1 infection +2 more
		CD79A	Unknown	33262464 28481359	Open Targets	B cell receptor signaling pathway Primary immunodeficiency CD22 mediated BCR regulation +1 more
		CD79B	Unknown	22810696 33262464	Open Targets	B cell receptor signaling pathway CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
		CDC73	Unknown	22810696 30038269 33262464 29316426 25344691 28481359	Open Targets	Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state +3 more
		CDH1	Unknown	22810696 33262464 26416732 29316426 31660073 25344691 24755471 28481359	Open Targets	Rap1 signaling pathway Apelin signaling pathway Hippo signaling pathway +15 more
		CDH10	Unknown	26416732 33262464 25344691 31660073	Open Targets	Adherens junctions interactions
		CDH11	Unknown	22810696 29967250 33262464 29937994 26416732 31660073 25344691	Open Targets	Adherens junctions interactions
		CDH17	Unknown	22810696 33262464 31660073	Open Targets	Gastric cancer Adherens junctions interactions
		CDK12	Unknown	29967250 30038269 22810696 33262464 29316426 31660073 36212424 24755471 26764183 28481359	Open Targets	TP53 Regulates Transcription of DNA Repair Genes
		CDK4	Unknown	33262464	Open Targets	Endocrine resistance Cell cycle p53 signaling pathway +40 more
		CDK6	Unknown	29316426 30239619 33262464	Open Targets	Cell cycle p53 signaling pathway PI3K-Akt signaling pathway +27 more
		CDKN1A	Unknown	31660073	Open Targets	Endocrine resistance Platinum drug resistance ErbB signaling pathway +56 more
		CDKN1B	Unknown	22810696 28481359 29316426 25344691 33262464	Open Targets	Endocrine resistance ErbB signaling pathway HIF-1 signaling pathway +28 more
		CDKN2A	Unknown	22810696 29967250 33262464 26416732 29316426 27756406 31400926 28481359 31226844	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CDKN2C	Unknown	26764183	Open Targets	Endocrine resistance Cell cycle Cushing syndrome +6 more
		CDX2	Unknown	28120820 33262464	Open Targets	Gastric cancer Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
		CEP43	Unknown	33262464 31660073	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes +6 more
		CEP89	Unknown	31660073	Open Targets	Anchoring of the basal body to the plasma membrane
		CHD2	Unknown	22810696 26109429 26764183 25344691 33262464	Open Targets	—
		CHD4	Unknown	22810696 30038269 33262464 26416732 25957691 31660073 30239619 24755471 26764183	Open Targets	ATP-dependent chromatin remodeling Human papillomavirus infection Viral carcinogenesis +5 more
		CHEK2	Unknown	29316426 25344691 28481359 27612425	Open Targets	Cell cycle p53 signaling pathway Cellular senescence +9 more
		CHST11	Unknown	30038269 26416732 33262464 25344691	Open Targets	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Chondroitin sulfate biosynthesis
		CIC	Unknown	33262464 29937994 29316426 25957691 25344691 28481359	Open Targets	Spinocerebellar ataxia
		CIITA	Unknown	22810696 24755471 26764183 25344691 31660073	Open Targets	Antigen processing and presentation Toxoplasmosis Tuberculosis +3 more
		CLIP1	Unknown	22810696 33262464 25344691	Open Targets	mTOR signaling pathway Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids +5 more
		CLP1	Unknown	31660073	Open Targets	mRNA surveillance pathway tRNA processing in the nucleus mRNA Splicing - Major Pathway +3 more
		CLTC	Unknown	31660073 26416732 26764183 25344691 27612425	Open Targets	Lysosome Endocytosis Synaptic vesicle cycle +18 more
		CLTCL1	Unknown	22810696 33262464	Open Targets	Lysosome Endocytosis Synaptic vesicle cycle +8 more
		CNBD1	Unknown	22810696 26416732	Open Targets	—
		CNBP	Unknown	31660073	Open Targets	—
		CNOT3	Unknown	33262464 29937994	Open Targets	RNA degradation Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
		CNTNAP2	Unknown	31660073 26416732 33262464 27612425	Open Targets	Cell adhesion molecules
		CNTRL	Unknown	26416732 33262464 29937994 30239619 31660073	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes +6 more
		COL1A1	Unknown	22810696 33262464 29937994 26416732 31660073 25344691 24755471	Open Targets	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +26 more
		COL2A1	Unknown	22810696 33262464 29937994 31660073	Open Targets	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +14 more
		COL3A1	Unknown	29967250 22810696 33262464 29937994 31660073 26109429 25344691 24755471 26764183	Open Targets	Platelet activation Cytoskeleton in muscle cells Relaxin signaling pathway +16 more
		COX6C	Unknown	24755471	Open Targets	Oxidative phosphorylation Metabolic pathways Cardiac muscle contraction +12 more
		CPEB3	Unknown	33262464	Open Targets	Oocyte meiosis Progesterone-mediated oocyte maturation
		CREB1	Unknown	33262464	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway Efferocytosis +53 more
		CREB3L1	Unknown	22810696 33262464	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway PI3K-Akt signaling pathway +32 more
		CREB3L2	Unknown	31660073	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway PI3K-Akt signaling pathway +32 more
		CREBBP	Unknown	22810696 29967250 29937994 26416732 29316426 31660073 25344691 26764183 28481359	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +52 more
		CRLF2	Unknown	29316426 28481359	Open Targets	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Interleukin-7 signaling
		CRNKL1	Unknown	22810696	Open Targets	Spliceosome mRNA Splicing - Major Pathway

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Rectum adenocarcinoma

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