Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
rectal tubular adenoma	MONDO_0006394	ABL1	Unknown	38725616	Open Targets	ErbB signaling pathway Ras signaling pathway Cell cycle +17 more
		ABL2	Unknown	38725616	Open Targets	ErbB signaling pathway Ras signaling pathway Chemical carcinogenesis - reactive oxygen species +2 more
		ACKR3	Unknown	38725616	Open Targets	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine receptors bind chemokines +1 more
		ACSL3	Unknown	38725616	Open Targets	Fatty acid biosynthesis Fatty acid degradation Metabolic pathways +8 more
		ACSL6	Unknown	38725616	Open Targets	Fatty acid biosynthesis Fatty acid degradation Metabolic pathways +7 more
		ACVR1	Unknown	38725616	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling TGF-beta signaling pathway +2 more
		ACVR2A	Unknown	38725616 15735733	Open Targets	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells +3 more
		AFDN	Unknown	38725616	Open Targets	Ras signaling pathway Rap1 signaling pathway cAMP signaling pathway +4 more
		AFF1	Unknown	38725616	Open Targets	Transcriptional misregulation in cancer
		AFF3	Unknown	38725616	Open Targets	—
		AFF4	Unknown	38725616	Open Targets	Viral life cycle - HIV-1 Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events +1 more
		AKAP9	Unknown	38725616	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +7 more
		AMER1	Unknown	38725616 28551381	Open Targets	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane +8 more
		ANK1	Unknown	38725616	Open Targets	Proteoglycans in cancer Interaction between L1 and Ankyrins Neurofascin interactions +1 more
		APC	Unknown	21837511 26613750 22848674 27609830 28548127 38725616 15376262 11821507 28551381	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		AR	Unknown	38725616	Open Targets	Oocyte meiosis Pathways in cancer Chemical carcinogenesis - receptor activation +7 more
		ARHGAP35	Unknown	38725616	Open Targets	Focal adhesion Platelet activation Leukocyte transendothelial migration +4 more
		ARID1A	Unknown	38725616	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID2	Unknown	38725616	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		ASPM	Unknown	38725616	Open Targets	—
		ASPSCR1	Unknown	38725616	Open Targets	Transcriptional misregulation in cancer
		ATM	Unknown	38725616	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		ATP2B3	Unknown	38725616	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +9 more
		ATR	Unknown	38725616	Open Targets	Fanconi anemia pathway Cell cycle p53 signaling pathway +13 more
		AXIN1	Unknown	38725616	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		AXIN2	Unknown	38725616 15735733	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +15 more
		BAP1	Unknown	38725616	Open Targets	Polycomb repressive complex UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
		BCL11A	Unknown	38725616	Open Targets	—
		BCL11B	Unknown	38725616	Open Targets	Transcriptional misregulation in cancer
		BCL9	Unknown	38725616	Open Targets	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex
		BCOR	Unknown	38725616	Open Targets	Polycomb repressive complex
		BCORL1	Unknown	38725616	Open Targets	Polycomb repressive complex
		BCR	Unknown	38725616	Open Targets	Pathways in cancer Chronic myeloid leukemia Signaling by cytosolic FGFR1 fusion mutants +2 more
		BIRC6	Unknown	38725616	Open Targets	Ubiquitin mediated proteolysis Autophagy - animal Apoptosis - multiple species
		BLM	Unknown	38725616	Open Targets	Homologous recombination Fanconi anemia pathway Processive synthesis on the C-strand of the telomere +10 more
		BMPR1A	Unknown	38725616	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling TGF-beta signaling pathway +4 more
		BRAF	Unknown	38725616	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BRCA2	Unknown	38725616	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		BRD3	Unknown	38725616	Open Targets	—
		BRD4	Unknown	38725616	Open Targets	—
		CAMTA1	Unknown	38725616	Open Targets	—
		CBFA2T3	Unknown	38725616	Open Targets	—
		CBLB	Unknown	38725616	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +5 more
		CCDC6	Unknown	38725616	Open Targets	Pathways in cancer Thyroid cancer
		CCNC	Unknown	38725616	Open Targets	PPARA activates gene expression Generic Transcription Pathway SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription +3 more
		CDH10	Unknown	38725616	Open Targets	Adherens junctions interactions
		CDH17	Unknown	38725616	Open Targets	Gastric cancer Adherens junctions interactions
		CDK12	Unknown	38725616	Open Targets	TP53 Regulates Transcription of DNA Repair Genes
		CDKN2C	Unknown	38725616	Open Targets	Endocrine resistance Cell cycle Cushing syndrome +6 more
		CHD2	Unknown	38725616	Open Targets	—

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Rectal tubular adenoma

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