Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
rectal tubular adenoma	MONDO_0006394	FOXO1	Unknown	38725616	Open Targets	FoxO signaling pathway AMPK signaling pathway Longevity regulating pathway +23 more
		GATA3	Unknown	38725616	Open Targets	Th1 and Th2 cell differentiation Th17 cell differentiation Parathyroid hormone synthesis, secretion and action +6 more
		GLI1	Unknown	38725616	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Pathways in cancer +5 more
		GMPS	Unknown	38725616	Open Targets	Purine metabolism Drug metabolism - other enzymes Metabolic pathways +2 more
		GOLPH3	Unknown	38725616	Open Targets	—
		GRM3	Unknown	38725616	Open Targets	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +3 more
		GTF2I	Unknown	38725616	Open Targets	Basal transcription factors cGMP-PKG signaling pathway
		HGF	Unknown	38725616	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +29 more
		HIP1	Unknown	38725616	Open Targets	Huntington disease Pathways of neurodegeneration - multiple diseases Clathrin-mediated endocytosis
		HLF	Unknown	38725616	Open Targets	—
		HNF1A	Unknown	38725616	Open Targets	Maturity onset diabetes of the young
		HOXA11	Unknown	38725616	Open Targets	Transcriptional misregulation in cancer
		HOXC11	Unknown	38725616	Open Targets	—
		HRAS	Unknown	38725616	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		IDH2	Unknown	38725616	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more
		IKBKB	Unknown	38725616	Open Targets	Antifolate resistance MAPK signaling pathway Ras signaling pathway +79 more
		IRF4	Unknown	38725616	Open Targets	Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling +1 more
		JAK1	Unknown	38725616	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		KAT6A	Unknown	38725616	Open Targets	Signaling pathways regulating pluripotency of stem cells HATs acetylate histones Regulation of TP53 Activity through Acetylation
		KAT6B	Unknown	38725616	Open Targets	HATs acetylate histones
		KDM5A	Unknown	38725616	Open Targets	HDMs demethylate histones
		KEAP1	Unknown	38725616	Open Targets	Ubiquitin mediated proteolysis Parkinson disease Pathways in cancer +6 more
		KIAA1549	Unknown	38725616	Open Targets	Signaling by BRAF and RAF fusions
		KLF6	Unknown	38725616	Open Targets	—
		KLK2	Unknown	38725616	Open Targets	Renin-angiotensin system Endocrine and other factor-regulated calcium reabsorption Activation of Matrix Metalloproteinases +2 more
		KMT2A	Unknown	38725616	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	38725616	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	38725616	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	21837511 23957258 22848674 1453686 27609830 28548127 11289147 9600124	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LARP4B	Unknown	38725616	Open Targets	—
		LATS2	Unknown	38725616	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LCK	Unknown	38725616	Open Targets	NF-kappa B signaling pathway Osteoclast differentiation Natural killer cell mediated cytotoxicity +27 more
		LOC105376156	Unknown	38725616	Open Targets	—
		LOC124905021	Unknown	38725616	Open Targets	—
		LRP1B	Unknown	38725616	Open Targets	—
		LYL1	Unknown	38725616	Open Targets	Transcriptional misregulation in cancer NGF-stimulated transcription
		LZTR1	Unknown	38725616	Open Targets	—
		MAML2	Unknown	38725616	Open Targets	Notch signaling pathway Th1 and Th2 cell differentiation Human papillomavirus infection +9 more
		MDM2	Unknown	38725616	Open Targets	Endocrine resistance Platinum drug resistance FoxO signaling pathway +35 more
		MECOM	Unknown	38725616	Open Targets	Lysine degradation Metabolic pathways MAPK signaling pathway +4 more
		MED12	Unknown	38725616	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MEN1	Unknown	38725616	Open Targets	Cushing syndrome Transcriptional misregulation in cancer Formation of the beta-catenin:TCF transactivating complex +5 more
		MET	Unknown	38725616	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MITF	Unknown	38725616	Open Targets	Mitophagy - animal Osteoclast differentiation Melanogenesis +4 more
		MLH1	Unknown	38725616	Open Targets	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MLLT10	Unknown	38725616	Open Targets	—
		MLLT3	Unknown	38725616	Open Targets	Viral life cycle - HIV-1 Transcriptional misregulation in cancer Formation of RNA Pol II elongation complex +2 more
		MN1	Unknown	38725616	Open Targets	—
		MPL	Unknown	38725616	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling JAK-STAT signaling pathway
		MSH2	Unknown	38725616	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +7 more

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Rectal tubular adenoma

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