Prostatic neoplasms

Cell cycle p53 signaling pathway Cellular senescence Human T-cell leukemia virus 1 infection Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation G2/M DNA damage checkpoint Stabilization of p53 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex +9 more

Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate Dermatan sulfate biosynthesis Defective CHST14 causes EDS, musculocontractural type

Virion - Hepatitis viruses Cell adhesion molecules Tight junction Leukocyte transendothelial migration Pathogenic Escherichia coli infection Hepatitis C +3 more

Virion - Hepatitis viruses Cell adhesion molecules Tight junction Leukocyte transendothelial migration Pathogenic Escherichia coli infection Hepatitis C +3 more

Virion - Hepatitis viruses Cell adhesion molecules Tight junction Leukocyte transendothelial migration Pathogenic Escherichia coli infection Hepatitis C +3 more

Complement and coagulation cascades Platelet degranulation Terminal pathway of complement Antimicrobial peptides Regulation of Complement cascade +2 more

RNA degradation Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain

Protein digestion and absorption Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Collagen chain trimerization +2 more

Cytoskeleton in muscle cells Protein digestion and absorption Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization +10 more

Cytoskeleton in muscle cells Protein digestion and absorption Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions MET activates PTK2 signaling Collagen chain trimerization +10 more

Steroid hormone biosynthesis Tyrosine metabolism Metabolic pathways Dopaminergic synapse Methylation Enzymatic degradation of dopamine by COMT Enzymatic degradation of Dopamine by monoamine oxidase +4 more

Glycerophospholipid biosynthesis Neutrophil degranulation

cGMP-PKG signaling pathway cAMP signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Adrenergic signaling in cardiomyocytes TNF signaling pathway Thermogenesis Cholinergic synapse Dopaminergic synapse Insulin secretion Estrogen signaling pathway Melanogenesis Thyroid hormone synthesis Glucagon signaling pathway Aldosterone synthesis and secretion Relaxin signaling pathway Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action Insulin resistance Cushing syndrome Growth hormone synthesis, secretion and action Vasopressin-regulated water reabsorption Huntington disease Prion disease Cocaine addiction Amphetamine addiction Alcoholism Hepatitis B Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Viral carcinogenesis Chemical carcinogenesis - receptor activation Prostate cancer +32 more

Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway HIF-1 signaling pathway FoxO signaling pathway Cell cycle Wnt signaling pathway Notch signaling pathway TGF-beta signaling pathway Adherens junction JAK-STAT signaling pathway Long-term potentiation Melanogenesis Thyroid hormone signaling pathway Glucagon signaling pathway Growth hormone synthesis, secretion and action Huntington disease Tuberculosis Hepatitis B Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Viral carcinogenesis MicroRNAs in cancer Renal cell carcinoma Prostate cancer Regulation of gene expression by Hypoxia-inducible Factor RORA activates gene expression Pre-NOTCH Transcription and Translation PPARA activates gene expression Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Attenuation phase Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock CD209 (DC-SIGN) signaling TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Activation of the TFAP2 (AP-2) family of transcription factors RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Regulation of FOXO transcriptional activity by acetylation +52 more

Neutrophil degranulation

Protein processing in endoplasmic reticulum Longevity regulating pathway - multiple species HSF1-dependent transactivation

Pentose and glucuronate interconversions Metabolic pathways Formation of xylulose-5-phosphate

Cytoskeleton in muscle cells

Salivary secretion

Wnt signaling pathway Notch signaling pathway Pathways in cancer Chronic myeloid leukemia Repression of WNT target genes TCF7L2 mutants don't bind CTBP +3 more

Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway Focal adhesion Adherens junction Signaling pathways regulating pluripotency of stem cells Leukocyte transendothelial migration Melanogenesis Thyroid hormone signaling pathway Cushing syndrome Alcoholic liver disease Alzheimer disease Pathways of neurodegeneration - multiple diseases Bacterial invasion of epithelial cells Salmonella infection Hepatitis C Human cytomegalovirus infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Proteoglycans in cancer Colorectal cancer Endometrial cancer Prostate cancer Thyroid cancer Basal cell carcinoma Breast cancer Hepatocellular carcinoma Gastric cancer Arrhythmogenic right ventricular cardiomyopathy Fluid shear stress and atherosclerosis Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade TCF dependent signaling in response to WNT Formation of the beta-catenin:TCF transactivating complex LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Apoptotic cleavage of cell adhesion proteins Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Adherens junctions interactions Binding of TCF/LEF:CTNNB1 to target gene promoters Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability Myogenesis Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated RHO GTPases activate IQGAPs Transcriptional Regulation by VENTX InlA-mediated entry of Listeria monocytogenes into host cells RUNX3 regulates WNT signaling +51 more

Autophagy - animal Lysosome Apoptosis Antigen processing and presentation NOD-like receptor signaling pathway Renin secretion Collagen degradation Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation Neutrophil degranulation +8 more

Sphingolipid signaling pathway Autophagy - animal Lysosome Apoptosis Estrogen signaling pathway Tuberculosis Diabetic cardiomyopathy Collagen degradation Metabolism of Angiotensinogen to Angiotensins MHC class II antigen presentation Neutrophil degranulation Estrogen-dependent gene expression +9 more

Ubiquitin mediated proteolysis Hedgehog signaling pathway Degradation of DVL Hedgehog 'on' state Regulation of RAS by GAPs Neddylation Antigen processing: Ubiquitination & Proteasome degradation +4 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway Efferocytosis TNF signaling pathway Human cytomegalovirus infection Chemokine receptors bind chemokines G alpha (i) signalling events +5 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway NF-kappa B signaling pathway Axon guidance Leukocyte transendothelial migration Intestinal immune network for IgA production Regulation of actin cytoskeleton Human cytomegalovirus infection Pathways in cancer Rheumatoid arthritis Nuclear signaling by ERBB4 Signaling by ROBO receptors Chemokine receptors bind chemokines G alpha (i) signalling events Estrogen-dependent gene expression +13 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway NF-kappa B signaling pathway Phospholipase D signaling pathway Cellular senescence Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway IL-17 signaling pathway Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Epithelial cell signaling in Helicobacter pylori infection Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Legionellosis Yersinia infection Chagas disease Malaria Amoebiasis Hepatitis B Human cytomegalovirus infection Influenza A Kaposi sarcoma-associated herpesvirus infection Coronavirus disease - COVID-19 Pathways in cancer Transcriptional misregulation in cancer Bladder cancer Rheumatoid arthritis Lipid and atherosclerosis Senescence-Associated Secretory Phenotype (SASP) Peptide ligand-binding receptors Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress G alpha (i) signalling events Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling +37 more

Steroid hormone biosynthesis Metabolic pathways Aldosterone synthesis and secretion Mineralocorticoid biosynthesis Glucocorticoid biosynthesis Endogenous sterols Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) +4 more

Steroid hormone biosynthesis Metabolic pathways Ovarian steroidogenesis Prolactin signaling pathway Cortisol synthesis and secretion Cushing syndrome Androgen biosynthesis Glucocorticoid biosynthesis Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) +6 more

Steroid hormone biosynthesis Metabolic pathways Ovarian steroidogenesis Estrogen biosynthesis Endogenous sterols Defective CYP19A1 causes Aromatase excess syndrome (AEXS) +3 more

Steroid hormone biosynthesis Tryptophan metabolism Retinol metabolism Metabolism of xenobiotics by cytochrome P450 Metabolic pathways Ovarian steroidogenesis Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Lipid and atherosclerosis PPARA activates gene expression Xenobiotics Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of protectins +12 more

Steroid hormone biosynthesis Tryptophan metabolism Metabolism of xenobiotics by cytochrome P450 Ovarian steroidogenesis Chemical carcinogenesis - DNA adducts MicroRNAs in cancer Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Endogenous sterols Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Defective CYP1B1 causes Glaucoma +9 more

Caffeine metabolism Retinol metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Drug metabolism - other enzymes Metabolic pathways Chemical carcinogenesis - DNA adducts Lipid and atherosclerosis Xenobiotics CYP2E1 reactions +7 more

Retinol metabolism Metabolic pathways Serotonergic synapse Chemical carcinogenesis - DNA adducts Xenobiotics +2 more

Arachidonic acid metabolism Linoleic acid metabolism Drug metabolism - cytochrome P450 Metabolic pathways Serotonergic synapse Chemical carcinogenesis - DNA adducts Xenobiotics CYP2E1 reactions Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) +7 more

Steroid hormone biosynthesis Arachidonic acid metabolism Linoleic acid metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Drug metabolism - other enzymes Metabolic pathways Non-alcoholic fatty liver disease Alcoholic liver disease Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - reactive oxygen species Xenobiotics CYP2E1 reactions Biosynthesis of maresin-like SPMs +11 more

Steroid hormone biosynthesis Linoleic acid metabolism Retinol metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Drug metabolism - other enzymes Metabolic pathways Bile secretion Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - receptor activation Xenobiotics Aflatoxin activation and detoxification Biosynthesis of maresin-like SPMs +10 more

Chemical carcinogenesis - DNA adducts Miscellaneous substrates Xenobiotics

Steroid hormone biosynthesis Retinol metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Metabolic pathways Chemical carcinogenesis - DNA adducts Xenobiotics Aflatoxin activation and detoxification +5 more

Primary bile acid biosynthesis Steroid hormone biosynthesis Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol Endogenous sterols Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) +4 more

Apoptosis TNF signaling pathway Regulation of RAS by GAPs

Virion - Lassa virus and SFTS virus ECM-receptor interaction Cytoskeleton in muscle cells Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Viral myocarditis ECM proteoglycans Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 O-linked glycosylation Regulation of expression of SLITs and ROBOs +10 more

Neddylation