Prostatic neoplasms

Oocyte meiosis Progesterone-mediated oocyte maturation APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Regulation of PLK1 Activity at G2/M Transition TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Activity through Phosphorylation FBXL7 down-regulates AURKA during mitotic entry and in early mitosis AURKA Activation by TPX2 Interaction between PHLDA1 and AURKA +6 more

Miscellaneous transport and binding events

Antigen processing and presentation Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection ER-Phagosome pathway Endosomal/Vacuolar pathway Nef mediated downregulation of MHC class I complex cell surface expression Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling Neutrophil degranulation Interferon gamma signaling Modulation by Mtb of host immune system Amyloid fiber formation Antigen Presentation: Folding, assembly and peptide loading of class I MHC +14 more

Glycosaminoglycan biosynthesis - keratan sulfate Glycosphingolipid biosynthesis - lacto and neolacto series Metabolic pathways Keratan sulfate biosynthesis N-Glycan antennae elongation +2 more

EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance ErbB signaling pathway Ras signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway Autophagy - animal PI3K-Akt signaling pathway Apoptosis VEGF signaling pathway Focal adhesion Neurotrophin signaling pathway Insulin signaling pathway Thyroid hormone signaling pathway Alzheimer disease Amyotrophic lateral sclerosis Prion disease Pathways of neurodegeneration - multiple diseases Toxoplasmosis Tuberculosis Hepatitis C Hepatitis B Measles Human papillomavirus infection Herpes simplex virus 1 infection Human immunodeficiency virus 1 infection Pathways in cancer Viral carcinogenesis Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Prostate cancer Melanoma Chronic myeloid leukemia Acute myeloid leukemia Non-small cell lung cancer Hepatocellular carcinoma Lipid and atherosclerosis Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members NRAGE signals death through JNK Constitutive Signaling by AKT1 E17K in Cancer +44 more

Polycomb repressive complex UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance Sphingolipid signaling pathway p53 signaling pathway Protein processing in endoplasmic reticulum Apoptosis Longevity regulating pathway Apoptosis - multiple species Necroptosis Neurotrophin signaling pathway Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Shigellosis Salmonella infection Tuberculosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer Transcriptional misregulation in cancer Viral carcinogenesis Colorectal cancer Pancreatic cancer Endometrial cancer Glioma Thyroid cancer Basal cell carcinoma Melanoma Chronic myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Lipid and atherosclerosis Release of apoptotic factors from the mitochondria Activation, translocation and oligomerization of BAX TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Transcriptional regulation by RUNX2 +52 more

ATP-dependent chromatin remodeling

Rap1 signaling pathway Chemokine signaling pathway Efferocytosis Focal adhesion Leukocyte transendothelial migration Regulation of actin cytoskeleton Growth hormone synthesis, secretion and action Bacterial invasion of epithelial cells Shigellosis Yersinia infection Human cytomegalovirus infection Downstream signal transduction p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases +12 more

EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance NF-kappa B signaling pathway HIF-1 signaling pathway Sphingolipid signaling pathway p53 signaling pathway Autophagy - animal Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Apoptosis Apoptosis - multiple species Necroptosis Adrenergic signaling in cardiomyocytes Hedgehog signaling pathway Focal adhesion NOD-like receptor signaling pathway JAK-STAT signaling pathway Neurotrophin signaling pathway Cholinergic synapse Estrogen signaling pathway Parathyroid hormone synthesis, secretion and action AGE-RAGE signaling pathway in diabetic complications Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Shigellosis Salmonella infection Toxoplasmosis Tuberculosis Hepatitis B Measles Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Colorectal cancer Prostate cancer Small cell lung cancer Gastric cancer Lipid and atherosclerosis Fluid shear stress and atherosclerosis Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling +46 more

Parathyroid hormone synthesis, secretion and action Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins +1 more

Platinum drug resistance Apoptosis Apoptosis - multiple species Hippo signaling pathway Hepatitis B Pathways in cancer Chemical carcinogenesis - receptor activation Colorectal cancer Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMOylation of DNA replication proteins RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain Mitotic Prometaphase Neddylation EML4 and NUDC in mitotic spindle formation +15 more

Cytokine-cytokine receptor interaction TGF-beta signaling pathway Axon guidance Hippo signaling pathway Molecules associated with elastic fibres +2 more

Cytokine-cytokine receptor interaction Hormone signaling TGF-beta signaling pathway Axon guidance Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells Fluid shear stress and atherosclerosis Signaling by BMP +5 more

FoxO signaling pathway Mitophagy - animal Autophagy - animal Shigellosis Legionellosis +2 more

EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway ErbB signaling pathway Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway FoxO signaling pathway mTOR signaling pathway Vascular smooth muscle contraction Focal adhesion Natural killer cell mediated cytotoxicity Long-term potentiation Neurotrophin signaling pathway Serotonergic synapse Long-term depression Regulation of actin cytoskeleton Insulin signaling pathway Progesterone-mediated oocyte maturation Parathyroid hormone synthesis, secretion and action Cushing syndrome Alzheimer disease Pathways of neurodegeneration - multiple diseases Alcoholism Hepatitis C Hepatitis B Pathways in cancer Proteoglycans in cancer Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Glioma Prostate cancer Thyroid cancer Melanoma Bladder cancer Chronic myeloid leukemia Acute myeloid leukemia Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Spry regulation of FGF signaling Frs2-mediated activation RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants +52 more

Platinum drug resistance Homologous recombination Fanconi anemia pathway Ubiquitin mediated proteolysis PI3K-Akt signaling pathway MicroRNAs in cancer Breast cancer SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Metalloprotease DUBs Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Transcriptional Regulation by E2F6 +19 more

Homologous recombination Fanconi anemia pathway Pathways in cancer Pancreatic cancer Breast cancer HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange +7 more

HATs acetylate histones Regulation of TP53 Activity through Acetylation

Neuroactive ligand-receptor interaction Hormone signaling Vascular smooth muscle contraction G alpha (s) signalling events Calcitonin-like ligand receptors ADORA2B mediated anti-inflammatory cytokines production Amyloid fiber formation +4 more

Protein processing in endoplasmic reticulum Phagosome Efferocytosis Antigen processing and presentation Chagas disease Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection ER-Phagosome pathway Assembly of Viral Components at the Budding Site Scavenging by Class A Receptors Scavenging by Class F Receptors ATF6 (ATF6-alpha) activates chaperone genes Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC +14 more

Autophagy - animal AMPK signaling pathway Longevity regulating pathway Adipocytokine signaling pathway Oxytocin signaling pathway Alcoholic liver disease Alcoholism CaMK IV-mediated phosphorylation of CREB CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Activation of RAC1 downstream of NMDARs +7 more

Shigellosis Degradation of the extracellular matrix Formation of the cornified envelope Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models +1 more

Platinum drug resistance p53 signaling pathway PI3K-Akt signaling pathway Apoptosis Apoptosis - multiple species VEGF signaling pathway Thyroid hormone signaling pathway Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Legionellosis Toxoplasmosis Tuberculosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer Colorectal cancer Pancreatic cancer Endometrial cancer Prostate cancer Small cell lung cancer Non-small cell lung cancer Viral myocarditis Lipid and atherosclerosis Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage NOD1/2 Signaling Pathway AKT phosphorylates targets in the cytosol Caspase activation via Dependence Receptors in the absence of ligand Constitutive Signaling by AKT1 E17K in Cancer Regulation of the apoptosome activity +39 more

Endocytosis Focal adhesion Prion disease Bacterial invasion of epithelial cells Proteoglycans in cancer Viral myocarditis Fluid shear stress and atherosclerosis eNOS activation NOSTRIN mediated eNOS trafficking Basigin interactions Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability Extra-nuclear estrogen signaling FOXO-mediated transcription of cell cycle genes +11 more

Endocytosis Focal adhesion Prion disease Bacterial invasion of epithelial cells Proteoglycans in cancer Fluid shear stress and atherosclerosis Extra-nuclear estrogen signaling +4 more

Arachidonic acid metabolism Folate biosynthesis Metabolism of xenobiotics by cytochrome P450 Metabolic pathways Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - reactive oxygen species Synthesis of Prostaglandins (PG) and Thromboxanes (TX) +4 more

HCMV Early Events

Endocrine resistance FoxO signaling pathway Cell cycle p53 signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Cellular senescence Wnt signaling pathway Hedgehog signaling pathway Apelin signaling pathway Hippo signaling pathway Focal adhesion Tight junction JAK-STAT signaling pathway Prolactin signaling pathway Thyroid hormone signaling pathway Oxytocin signaling pathway AGE-RAGE signaling pathway in diabetic complications Cushing syndrome Alcoholic liver disease Hepatitis C Measles Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Pathways in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Colorectal cancer Pancreatic cancer Endometrial cancer Glioma Prostate cancer Thyroid cancer Melanoma Bladder cancer Chronic myeloid leukemia Acute myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Viral myocarditis SCF(Skp2)-mediated degradation of p27/p21 RMTs methylate histone arginines Interleukin-4 and Interleukin-13 signaling Cyclin D associated events in G1 Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates Cell Cycle Transcriptional Regulation by VENTX Transcriptional regulation by RUNX2 Regulation of RUNX1 Expression and Activity RUNX3 regulates WNT signaling RUNX3 regulates p14-ARF Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling +58 more

FoxO signaling pathway Cell cycle p53 signaling pathway PI3K-Akt signaling pathway Cellular senescence Wnt signaling pathway Hedgehog signaling pathway Hippo signaling pathway Focal adhesion JAK-STAT signaling pathway Prolactin signaling pathway Measles Human papillomavirus infection Human T-cell leukemia virus 1 infection Epstein-Barr virus infection Pathways in cancer Transcriptional misregulation in cancer Viral carcinogenesis MicroRNAs in cancer Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity +18 more

Basal transcription factors Nucleotide excision repair Cell cycle Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of Incision Complex in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE RUNX1 regulates transcription of genes involved in differentiation of HSCs +24 more

Cell adhesion molecules

Virion - Hepatitis viruses Hematopoietic cell lineage Platelet degranulation Acrosome Reaction and Sperm:Oocyte Membrane Binding Uptake and function of diphtheria toxin +2 more

MAPK signaling pathway Cell cycle Progesterone-mediated oocyte maturation MicroRNAs in cancer Cyclin A/B1/B2 associated events during G2/M transition Cyclin A:Cdk2-associated events at S phase entry Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models +4 more

Cell cycle Oocyte meiosis Ubiquitin mediated proteolysis Progesterone-mediated oocyte maturation Human T-cell leukemia virus 1 infection Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Antigen processing: Ubiquitination & Proteasome degradation +18 more

Rap1 signaling pathway Apelin signaling pathway Hippo signaling pathway Cell adhesion molecules Adherens junction Bacterial invasion of epithelial cells Pathways in cancer Endometrial cancer Thyroid cancer Melanoma Bladder cancer Gastric cancer Degradation of the extracellular matrix Integrin cell surface interactions Apoptotic cleavage of cell adhesion proteins Adherens junctions interactions RHO GTPases activate IQGAPs InlA-mediated entry of Listeria monocytogenes into host cells +15 more

Adherens junctions interactions

Adherens junctions interactions

TP53 Regulates Transcription of DNA Repair Genes

ATP-dependent chromatin remodeling

Endocrine resistance Platinum drug resistance ErbB signaling pathway HIF-1 signaling pathway FoxO signaling pathway Cell cycle p53 signaling pathway PI3K-Akt signaling pathway Cellular senescence JAK-STAT signaling pathway Oxytocin signaling pathway Parathyroid hormone synthesis, secretion and action Cushing syndrome Hepatitis C Hepatitis B Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Pathways in cancer Transcriptional misregulation in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Glioma Prostate cancer Thyroid cancer Basal cell carcinoma Melanoma Bladder cancer Chronic myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Constitutive Signaling by AKT1 E17K in Cancer Interleukin-4 and Interleukin-13 signaling TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry Transcriptional activation of cell cycle inhibitor p21 The role of GTSE1 in G2/M progression after G2 checkpoint TFAP2 (AP-2) family regulates transcription of cell cycle factors Transcriptional regulation by RUNX2 RUNX3 regulates CDKN1A transcription Transcriptional regulation of granulopoiesis FOXO-mediated transcription of cell cycle genes +56 more

Endocrine resistance ErbB signaling pathway HIF-1 signaling pathway FoxO signaling pathway Cell cycle PI3K-Akt signaling pathway AGE-RAGE signaling pathway in diabetic complications Cushing syndrome Measles Human papillomavirus infection Epstein-Barr virus infection Pathways in cancer Transcriptional misregulation in cancer Viral carcinogenesis MicroRNAs in cancer Prostate cancer Chronic myeloid leukemia Small cell lung cancer Gastric cancer SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Constitutive Signaling by AKT1 E17K in Cancer TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates Cell Cycle Estrogen-dependent nuclear events downstream of ESR-membrane signaling +28 more

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Polo-like kinase mediated events Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation +4 more

Estrogen-dependent gene expression

ATP-dependent chromatin remodeling HDACs deacetylate histones SUMOylation of chromatin organization proteins Regulation of TP53 Activity through Acetylation RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription +3 more