Polycystic ovary syndrome

PPAR signaling pathway Efferocytosis AMPK signaling pathway Longevity regulating pathway Osteoclast differentiation Thermogenesis Non-alcoholic fatty liver disease Huntington disease Pathways in cancer Transcriptional misregulation in cancer Thyroid cancer Lipid and atherosclerosis PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of PTEN gene transcription +13 more

Rap1 signaling pathway Aldosterone synthesis and secretion Chemical carcinogenesis - reactive oxygen species Sphingolipid de novo biosynthesis +1 more

Calcium signaling pathway Neuroactive ligand-receptor interaction Staphylococcus aureus infection Class A/1 (Rhodopsin-like receptors) G alpha (q) signalling events Interleukin-10 signaling Neutrophil degranulation Interferon gamma signaling +5 more

Notch signaling pathway Transcriptional misregulation in cancer

Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Regulation of lipolysis in adipocytes Human cytomegalovirus infection Pathways in cancer Prostanoid ligand receptors G alpha (i) signalling events +5 more

AMPK signaling pathway Golgi Cisternae Pericentriolar Stack Reorganization RAB geranylgeranylation

Ras signaling pathway Mitophagy - animal Endocytosis Phagosome Efferocytosis Vasopressin-regulated water reabsorption Salmonella infection Amoebiasis Tuberculosis Neutrophil degranulation TBC/RABGAPs Clathrin-mediated endocytosis RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs +11 more

Rho GTPase cycle MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic Kinesins +1 more

Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) Retinoid metabolism disease events Retinoid metabolism and transport +1 more

Ribosome biogenesis in eukaryotes

RHO GTPases Activate Rhotekin and Rhophilins

Trafficking of myristoylated proteins to the cilium

DNA replication Nucleotide excision repair Mismatch repair Homologous recombination Fanconi anemia pathway Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress SUMOylation of DNA damage response and repair proteins Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint +30 more

Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +7 more

Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +10 more

Purine metabolism Pyrimidine metabolism Glutathione metabolism Drug metabolism - other enzymes Metabolic pathways Nucleotide metabolism p53 signaling pathway Interconversion of nucleotide di- and triphosphates G1/S-Specific Transcription Transcriptional Regulation by E2F6 +7 more

Post-translational modification: synthesis of GPI-anchored proteins

Olfactory Signaling Pathway

Th1 and Th2 cell differentiation Epstein-Barr virus infection Binding of TCF/LEF:CTNNB1 to target gene promoters RUNX3 regulates CDKN1A transcription RUNX3 regulates NOTCH signaling Regulation of RUNX3 expression and activity RUNX3 Regulates Immune Response and Cell Migration RUNX3 regulates WNT signaling RUNX3 regulates YAP1-mediated transcription RUNX3 regulates RUNX1-mediated transcription RUNX3 regulates p14-ARF RUNX3 regulates BCL2L11 (BIM) transcription +9 more

IL-17 signaling pathway Metal sequestration by antimicrobial proteins

Neutrophil degranulation

Epstein-Barr virus infection HDACs deacetylate histones

Taste transduction Aldosterone-regulated sodium reabsorption Stimuli-sensing channels

Neuroactive ligand-receptor interaction Pancreatic secretion Bile secretion G alpha (s) signalling events Glucagon-type ligand receptors ADORA2B mediated anti-inflammatory cytokines production +3 more

Surfactant metabolism Defective pro-SFTPC causes pulmonary surfactant metabolism dysfunction 2 (SMDP2) and respiratory distress syndrome (RDS) Defective CSF2RB causes pulmonary surfactant metabolism dysfunction 5 (SMDP5) Defective CSF2RA causes pulmonary surfactant metabolism dysfunction 4 (SMDP4) +1 more

Protein digestion and absorption Amino acid transport across the plasma membrane Tryptophan catabolism

Cytoskeleton in muscle cells NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport +2 more

Steroid hormone biosynthesis Metabolic pathways Androgen biosynthesis

Spliceosome mRNA Splicing - Major Pathway

Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors G alpha (i) signalling events +1 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Growth hormone synthesis, secretion and action Peptide ligand-binding receptors G alpha (i) signalling events +3 more

Ovarian steroidogenesis Aldosterone synthesis and secretion Cortisol synthesis and secretion Cushing syndrome Cholesterol metabolism Pregnenolone biosynthesis +3 more

Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis

Sulfur metabolism Metabolic pathways Sulfide oxidation to sulfate

MAPK signaling pathway NF-kappa B signaling pathway Osteoclast differentiation Toll-like receptor signaling pathway NOD-like receptor signaling pathway TNF signaling pathway Alcoholic liver disease Pathogenic Escherichia coli infection Shigellosis Salmonella infection Yersinia infection Leishmaniasis Toxoplasmosis Hepatitis B Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Lipid and atherosclerosis NOD1/2 Signaling Pathway FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NFkappaB signaling pathway CLEC7A (Dectin-1) signaling Ub-specific processing proteases TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation +29 more

Hippo signaling pathway Hippo signaling pathway - multiple species YAP1- and WWTR1 (TAZ)-stimulated gene expression RUNX3 regulates YAP1-mediated transcription +1 more

Virion - Lassa virus and SFTS virus HIF-1 signaling pathway Endocytosis Phagosome Ferroptosis TGF-beta signaling pathway Hematopoietic cell lineage Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Transferrin endocytosis and recycling +8 more

tRNA modification in the nucleus and cytosol