Polycystic ovary syndrome

Inositol phosphate metabolism Metabolic pathways Synthesis of IP2, IP, and Ins in the cytosol

Formation of the cornified envelope

Major pathway of rRNA processing in the nucleolus and cytosol

Keratinization Formation of the cornified envelope

Cytokine-cytokine receptor interaction Neuroactive ligand-receptor interaction Hormone signaling AMPK signaling pathway JAK-STAT signaling pathway Adipocytokine signaling pathway Non-alcoholic fatty liver disease Transcriptional regulation of white adipocyte differentiation Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and deacylation of Ghrelin +7 more

cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling GnRH signaling pathway Ovarian steroidogenesis Prolactin signaling pathway GnRH secretion Androgen biosynthesis Mineralocorticoid biosynthesis Glycoprotein hormones Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production Reactions specific to the complex N-glycan synthesis pathway +11 more

Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Ovarian steroidogenesis Prolactin signaling pathway Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production +6 more

Cytokine-cytokine receptor interaction Signaling pathways regulating pluripotency of stem cells JAK-STAT signaling pathway TNF signaling pathway Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling IL-6-type cytokine receptor ligand interactions +4 more

Cytokine-cytokine receptor interaction Signaling pathways regulating pluripotency of stem cells JAK-STAT signaling pathway IL-6-type cytokine receptor ligand interactions RUNX1 regulates transcription of genes involved in interleukin signaling +2 more

Apoptosis Cytoskeleton in muscle cells Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Breakdown of the nuclear lamina XBP1(S) activates chaperone genes Depolymerisation of the Nuclear Lamina Signaling by BRAF and RAF fusions +8 more

Cytoskeleton in muscle cells

Glycerophospholipid metabolism Ether lipid metabolism Metabolic pathways Acyl chain remodelling of PC +1 more

Neurexins and neuroligins

RNA degradation Spliceosome mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway +1 more

Cell cycle Oocyte meiosis Progesterone-mediated oocyte maturation Human T-cell leukemia virus 1 infection Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components Inactivation of APC/C via direct inhibition of the APC/C complex Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Cdc20:Phospho-APC/C mediated degradation of Cyclin A APC/C:Cdc20 mediated degradation of mitotic proteins APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation +12 more

Notch signaling pathway Th1 and Th2 cell differentiation Human papillomavirus infection Pre-NOTCH Transcription and Translation NOTCH1 Intracellular Domain Regulates Transcription NOTCH2 intracellular domain regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription +9 more

N-glycan trimming and elongation in the cis-Golgi

MAPK signaling pathway

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane RHO GTPases Activate Formins Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 EML4 and NUDC in mitotic spindle formation +11 more

Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production +2 more

N-Glycan biosynthesis Mannose type O-glycan biosynthesis Metabolic pathways

Platinum drug resistance Mismatch repair Pathways in cancer Colorectal cancer Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Defective Mismatch Repair Associated With MSH2 Defective Mismatch Repair Associated With MSH6 +4 more

Neuroactive ligand-receptor interaction Circadian entrainment Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events +1 more

Fc gamma R-mediated phagocytosis Motor proteins Pathogenic Escherichia coli infection Regulation of actin dynamics for phagocytic cup formation FCGR3A-mediated phagocytosis +2 more

Base excision repair Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway +1 more

Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation

Nicotinate and nicotinamide metabolism Metabolic pathways Biosynthesis of cofactors Nicotinate metabolism +1 more

Neuroactive ligand-receptor interaction Peptide ligand-binding receptors G alpha (i) signalling events

EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Amyotrophic lateral sclerosis Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling PIP3 activates AKT signaling GRB7 events in ERBB2 signaling Downregulation of ERBB2:ERBB3 signaling GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Downregulation of ERBB2 signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants +18 more

Purine metabolism Metabolic pathways cGMP-PKG signaling pathway cAMP signaling pathway Apelin signaling pathway Insulin signaling pathway Progesterone-mediated oocyte maturation Glucagon signaling pathway Regulation of lipolysis in adipocytes Renin secretion Morphine addiction PDE3B signalling G alpha (s) signalling events +10 more

Cytoskeleton in muscle cells

Pathways in cancer NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events +1 more

Glycerolipid metabolism Metabolic pathways Thermogenesis Regulation of lipolysis in adipocytes Acyl chain remodeling of DAG and TAG Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation +4 more