Subtype of: Mesothelioma

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
pleural epithelioid mesothelioma	MONDO_0006378	LRP1B	Unknown	25488749 26928227	Open Targets	—
		MACC1	Unknown	25488749	Open Targets	—
		MAP2K1	Unknown	27127140 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +99 more
		MAP3K1	Unknown	27127140	Open Targets	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MAP3K13	Unknown	26928227	Open Targets	MAPK signaling pathway
		MAPK1	Unknown	26928227	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +161 more
		MLH1	Unknown	26928227	Open Targets	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MLLT10	Unknown	26928227	Open Targets	—
		MSH6	Unknown	28481359	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +4 more
		MUC16	Unknown	26928227	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC4	Unknown	25488749 26928227	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MYC	Unknown	25488749	Open Targets	MAPK signaling pathway ErbB signaling pathway Cell cycle +45 more
		MYCN	Unknown	28481359	Open Targets	Transcriptional misregulation in cancer
		MYH9	Unknown	26928227	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +8 more
		MYO5A	Unknown	25488749	Open Targets	Motor proteins Pathogenic Escherichia coli infection Regulation of actin dynamics for phagocytic cup formation +1 more
		NBEA	Unknown	25488749	Open Targets	—
		NCOR2	Unknown	28344893 26928227	Open Targets	Notch signaling pathway Epstein-Barr virus infection PPARA activates gene expression +11 more
		NDRG1	Unknown	26928227	Open Targets	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
		NF1	Unknown	26928227	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NF2	Unknown	23435014 27127140 27566247 25902174 26463840 25488749 28481359 26928227	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Tight junction +2 more
		NFIB	Unknown	26928227	Open Targets	—
		NOTCH2	Unknown	28481359	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NSD1	Unknown	26928227	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		NSD3	Unknown	26928227	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		NTRK1	Unknown	25488749	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +13 more
		NUMA1	Unknown	26928227	Open Targets	Recruitment of NuMA to mitotic centrosomes Mitotic Prophase
		NUTM2D	Unknown	26928227	Open Targets	—
		PAX5	Unknown	28481359	Open Targets	Transcriptional misregulation in cancer RUNX1 regulates transcription of genes involved in BCR signaling
		PBRM1	Unknown	28481359 26928227	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		PCM1	Unknown	26928227	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +4 more
		PDE4DIP	Unknown	26928227	Open Targets	—
		PDGFRA	Unknown	26928227	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more
		PDGFRB	Unknown	25488749	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +22 more
		PHOX2B	Unknown	25488749	Open Targets	—
		PIK3CA	Unknown	25174276 28481359 26928227	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3R1	Unknown	26928227	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +150 more
		PML	Unknown	26928227	Open Targets	Ubiquitin mediated proteolysis Endocytosis Influenza A +12 more
		PMS2	Unknown	28481359	Open Targets	Mismatch repair Fanconi anemia pathway Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) +3 more
		POLE	Unknown	26928227	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		PPARG	Unknown	26928227	Open Targets	PPAR signaling pathway Efferocytosis AMPK signaling pathway +13 more
		PPP2R1A	Unknown	26928227	Open Targets	mRNA surveillance pathway Sphingolipid signaling pathway Cell cycle +52 more
		PRDM1	Unknown	26928227	Open Targets	Regulation of TP53 Expression
		PRDM2	Unknown	26928227	Open Targets	Lysine degradation Metabolic pathways
		PTCH1	Unknown	25488749	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTEN	Unknown	28481359	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPN11	Unknown	25174276	Open Targets	Ras signaling pathway Phospholipase D signaling pathway Efferocytosis +56 more
		PTPN13	Unknown	26928227	Open Targets	Apoptosis Synthesis of PIPs at the plasma membrane Interleukin-37 signaling
		PTPRC	Unknown	26928227	Open Targets	Cell adhesion molecules T cell receptor signaling pathway Fc gamma R-mediated phagocytosis +5 more
		PTPRT	Unknown	26554828 26928227	Open Targets	—
		PWWP2A	Unknown	26928227	Open Targets	—

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Pleural epithelioid mesothelioma

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