Subtype of: Mesothelioma

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
pleural epithelioid mesothelioma	MONDO_0006378	ABI1	Unknown	26928227	Open Targets	Pathogenic Escherichia coli infection Salmonella infection Regulation of actin dynamics for phagocytic cup formation +3 more
		ABL1	Unknown	28481359	Open Targets	ErbB signaling pathway Ras signaling pathway Cell cycle +17 more
		ACSL6	Unknown	26928227	Open Targets	Fatty acid biosynthesis Fatty acid degradation Metabolic pathways +7 more
		ACVR1B	Unknown	25488749	Open Targets	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells +1 more
		AFF4	Unknown	26928227	Open Targets	Viral life cycle - HIV-1 Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events +1 more
		AKAP9	Unknown	26928227	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +7 more
		AKT1	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +131 more
		AKT2	Unknown	26928227	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +122 more
		ALK	Unknown	25174276	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		ANK1	Unknown	26928227	Open Targets	Proteoglycans in cancer Interaction between L1 and Ankyrins Neurofascin interactions +1 more
		APC	Unknown	25174276 26928227	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		AR	Unknown	26928227	Open Targets	Oocyte meiosis Pathways in cancer Chemical carcinogenesis - receptor activation +7 more
		ARAF	Unknown	25488749	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +41 more
		ARHGAP35	Unknown	26928227	Open Targets	Focal adhesion Platelet activation Leukocyte transendothelial migration +4 more
		ARHGAP5	Unknown	26928227	Open Targets	Focal adhesion Leukocyte transendothelial migration Rho GTPase cycle
		ARHGEF10L	Unknown	25488749	Open Targets	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
		ARID1A	Unknown	26928227	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID1B	Unknown	26928227	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID2	Unknown	25488749 28481359 26928227	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		ARNT	Unknown	26928227	Open Targets	HIF-1 signaling pathway Efferocytosis Cushing syndrome +10 more
		ASXL1	Unknown	27127140 26928227	Open Targets	Polycomb repressive complex UCH proteinases
		ASXL2	Unknown	26928227	Open Targets	Polycomb repressive complex UCH proteinases
		ATM	Unknown	38109438 27091358 26928227	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		ATP1A1	Unknown	26928227	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway Cardiac muscle contraction +18 more
		ATR	Unknown	26928227	Open Targets	Fanconi anemia pathway Cell cycle p53 signaling pathway +13 more
		BAP1	Unknown	21642991 26463840 28344893 27127140 22321046 38109438 25488749 21874000 28481359 26928227	Open Targets	Polycomb repressive complex UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
		BCL10	Unknown	26928227	Open Targets	NF-kappa B signaling pathway C-type lectin receptor signaling pathway T cell receptor signaling pathway +8 more
		BCL11A	Unknown	26928227	Open Targets	—
		BCL6	Unknown	27127140	Open Targets	FoxO signaling pathway Transcriptional misregulation in cancer Chemical carcinogenesis - receptor activation +3 more
		BIRC6	Unknown	26928227	Open Targets	Ubiquitin mediated proteolysis Autophagy - animal Apoptosis - multiple species
		BRAF	Unknown	26463840 23558893 29146159	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BRCA1	Unknown	26928227	Open Targets	Platinum drug resistance Homologous recombination Fanconi anemia pathway +19 more
		BRCA2	Unknown	38109438 28481359 26928227	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		CANT1	Unknown	25488749	Open Targets	Purine metabolism Pyrimidine metabolism Metabolic pathways +2 more
		CARS1	Unknown	26928227	Open Targets	Aminoacyl-tRNA biosynthesis Cytosolic tRNA aminoacylation
		CBL	Unknown	26928227	Open Targets	ErbB signaling pathway Ubiquitin mediated proteolysis Endocytosis +22 more
		CD28	Unknown	26928227	Open Targets	Cell adhesion molecules T cell receptor signaling pathway Intestinal immune network for IgA production +16 more
		CDH1	Unknown	25488749	Open Targets	Rap1 signaling pathway Apelin signaling pathway Hippo signaling pathway +15 more
		CDK12	Unknown	27127140 26928227	Open Targets	TP53 Regulates Transcription of DNA Repair Genes
		CDKN2A	Unknown	20591913 11172613 23270897 27127140 12117769 38109438 28481359 26928227	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CHEK2	Unknown	25488749 26928227	Open Targets	Cell cycle p53 signaling pathway Cellular senescence +9 more
		CIITA	Unknown	26928227	Open Targets	Antigen processing and presentation Toxoplasmosis Tuberculosis +3 more
		CLIP1	Unknown	25488749	Open Targets	mTOR signaling pathway Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids +5 more
		COL1A1	Unknown	26928227	Open Targets	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +26 more
		CREB3L1	Unknown	25488749	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway PI3K-Akt signaling pathway +32 more
		CREBBP	Unknown	28481359 26928227	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +52 more
		CSF3R	Unknown	26928227	Open Targets	Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway JAK-STAT signaling pathway +3 more
		CSMD3	Unknown	26928227	Open Targets	—
		CTCF	Unknown	26928227	Open Targets	—
		CTNNA2	Unknown	26928227	Open Targets	Hippo signaling pathway Adherens junction Leukocyte transendothelial migration +6 more

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Pleural epithelioid mesothelioma

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