Subtype of: Mesothelioma

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
pleural epithelioid mesothelioma	MONDO_0006378	RAD51C	Unknown	28481359	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +5 more
		RANBP2	Unknown	26928227	Open Targets	Nucleocytoplasmic transport Viral life cycle - HIV-1 Amyotrophic lateral sclerosis +32 more
		RARA	Unknown	26928227	Open Targets	Th17 cell differentiation Estrogen signaling pathway Pathways in cancer +6 more
		RASA1	Unknown	26928227	Open Targets	MAPK signaling pathway Ras signaling pathway Axon guidance +5 more
		RB1	Unknown	26928227	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		RBM10	Unknown	26928227	Open Targets	—
		RECQL4	Unknown	28481359	Open Targets	—
		REL	Unknown	26928227	Open Targets	Ras signaling pathway Transcriptional misregulation in cancer Viral carcinogenesis +1 more
		RET	Unknown	27127140 28481359	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		RGS7	Unknown	25488749	Open Targets	G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
		RHOA	Unknown	26554828 26928227	Open Targets	Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway +64 more
		RICTOR	Unknown	28344893	Open Targets	mTOR signaling pathway PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling +3 more
		RNF213	Unknown	26928227	Open Targets	Suppression of apoptosis Antigen processing: Ubiquitination & Proteasome degradation
		ROBO2	Unknown	26928227	Open Targets	Axon guidance Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO
		ROS1	Unknown	26928227	Open Targets	—
		RPL5	Unknown	26928227	Open Targets	Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression +7 more
		SDHA	Unknown	26928227	Open Targets	Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways +12 more
		SDHD	Unknown	26928227	Open Targets	Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways +12 more
		SETBP1	Unknown	26928227	Open Targets	—
		SETD1B	Unknown	26928227	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		SETD2	Unknown	28344893 28481359 26928227	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		SETDB1	Unknown	28344893 26928227	Open Targets	Lysine degradation Metabolic pathways Signaling pathways regulating pluripotency of stem cells +1 more
		SF3B1	Unknown	27127140 26928227	Open Targets	Spliceosome B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway +1 more
		SFPQ	Unknown	26928227	Open Targets	PTK6 Regulates Proteins Involved in RNA Processing Suppression of apoptosis
		SMAD3	Unknown	26928227	Open Targets	FoxO signaling pathway Cell cycle Endocytosis +34 more
		SMAD4	Unknown	26928227	Open Targets	FoxO signaling pathway Hormone signaling Cell cycle +30 more
		SMARCA4	Unknown	26928227	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +6 more
		SRGAP3	Unknown	25488749	Open Targets	Axon guidance Rho GTPase cycle
		SRSF3	Unknown	26928227	Open Targets	Spliceosome Amyotrophic lateral sclerosis Herpes simplex virus 1 infection +4 more
		STAG2	Unknown	26928227	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		STK11	Unknown	26463840 27127140	Open Targets	FoxO signaling pathway Hormone signaling Autophagy - animal +9 more
		SUFU	Unknown	28481359 26928227	Open Targets	Hedgehog signaling pathway Pathways in cancer Basal cell carcinoma +4 more
		TBL1XR1	Unknown	26928227	Open Targets	Wnt signaling pathway RORA activates gene expression PPARA activates gene expression +11 more
		TERT	Unknown	25488749	Open Targets	Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer +4 more
		TET1	Unknown	25488749 26928227	Open Targets	—
		TET2	Unknown	26928227	Open Targets	—
		TNC	Unknown	26928227	Open Targets	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +6 more
		TOP1	Unknown	25488749	Open Targets	SUMOylation of DNA replication proteins
		TP53	Unknown	23435014 26554828 28344893 27127140 27091358 25174276 25488749 28481359 26928227	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TP63	Unknown	28481359 26928227	Open Targets	MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes +5 more
		TPM3	Unknown	26928227	Open Targets	Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Motor proteins +7 more
		TRAF7	Unknown	28481359 26928227	Open Targets	Antigen processing: Ubiquitination & Proteasome degradation
		TRIM24	Unknown	25488749 26928227	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF fusions
		TRIP11	Unknown	25488749	Open Targets	Intraflagellar transport Intra-Golgi traffic
		TSC1	Unknown	27127140 26928227	Open Targets	Phospholipase D signaling pathway Autophagy - animal mTOR signaling pathway +15 more
		TSC2	Unknown	27127140	Open Targets	Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal +19 more
		USP9X	Unknown	26554828 26928227	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes +2 more
		VAV1	Unknown	26928227	Open Targets	Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway +30 more
		VHL	Unknown	25174276	Open Targets	HIF-1 signaling pathway Ubiquitin mediated proteolysis Pathways in cancer +5 more
		WRN	Unknown	26928227	Open Targets	Processive synthesis on the C-strand of the telomere Removal of the Flap Intermediate from the C-strand SUMOylation of DNA damage response and repair proteins +9 more

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Pleural epithelioid mesothelioma

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