Pleural epithelioid mesothelioma

Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway Focal adhesion Adherens junction Signaling pathways regulating pluripotency of stem cells Leukocyte transendothelial migration Melanogenesis Thyroid hormone signaling pathway Cushing syndrome Alcoholic liver disease Alzheimer disease Pathways of neurodegeneration - multiple diseases Bacterial invasion of epithelial cells Salmonella infection Hepatitis C Human cytomegalovirus infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Proteoglycans in cancer Colorectal cancer Endometrial cancer Prostate cancer Thyroid cancer Basal cell carcinoma Breast cancer Hepatocellular carcinoma Gastric cancer Arrhythmogenic right ventricular cardiomyopathy Fluid shear stress and atherosclerosis Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade TCF dependent signaling in response to WNT Formation of the beta-catenin:TCF transactivating complex LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Apoptotic cleavage of cell adhesion proteins Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Adherens junctions interactions Binding of TCF/LEF:CTNNB1 to target gene promoters Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability Myogenesis Misspliced GSK3beta mutants stabilize beta-catenin S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated RHO GTPases activate IQGAPs Transcriptional Regulation by VENTX InlA-mediated entry of Listeria monocytogenes into host cells RUNX3 regulates WNT signaling +51 more

Wnt signaling pathway

Ubiquitin mediated proteolysis Hedgehog signaling pathway Degradation of DVL Hedgehog 'on' state Regulation of RAS by GAPs Neddylation Antigen processing: Ubiquitination & Proteasome degradation +4 more

RIG-I-like receptor signaling pathway Hepatitis B Viral carcinogenesis Neutrophil degranulation +1 more

MicroRNAs in cancer MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis

Cysteine and methionine metabolism Metabolic pathways Efferocytosis MicroRNAs in cancer PRC2 methylates histones and DNA RMTs methylate histone arginines +3 more

Ribosome biogenesis in eukaryotes Proteoglycans in cancer MicroRNA (miRNA) biogenesis

EGFR tyrosine kinase inhibitor resistance Endocrine resistance Virion - Hepatitis viruses MAPK signaling pathway ErbB signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway HIF-1 signaling pathway FoxO signaling pathway Phospholipase D signaling pathway Endocytosis PI3K-Akt signaling pathway Focal adhesion Adherens junction Gap junction JAK-STAT signaling pathway Regulation of actin cytoskeleton GnRH signaling pathway Estrogen signaling pathway Oxytocin signaling pathway Relaxin signaling pathway Parathyroid hormone synthesis, secretion and action Cushing syndrome Epithelial cell signaling in Helicobacter pylori infection Shigellosis Hepatitis C Human cytomegalovirus infection Human papillomavirus infection Coronavirus disease - COVID-19 Pathways in cancer Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Pancreatic cancer Endometrial cancer Glioma Prostate cancer Melanoma Bladder cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Signaling by ERBB4 SHC1 events in ERBB2 signaling PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma EGFR Transactivation by Gastrin Constitutive Signaling by Aberrant PI3K in Cancer Signal transduction by L1 Constitutive Signaling by EGFRvIII Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis PTK6 promotes HIF1A stabilization Downregulation of ERBB2 signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors Extra-nuclear estrogen signaling NOTCH3 Activation and Transmission of Signal to the Nucleus HCMV Early Events Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants +79 more

Cytoskeleton in muscle cells Protein digestion and absorption Degradation of the extracellular matrix Elastic fibre formation Molecules associated with elastic fibres +2 more

Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer EML4 and NUDC in mitotic spindle formation +1 more

Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway HIF-1 signaling pathway FoxO signaling pathway Cell cycle Wnt signaling pathway Notch signaling pathway TGF-beta signaling pathway Adherens junction JAK-STAT signaling pathway Long-term potentiation Melanogenesis Thyroid hormone signaling pathway Glucagon signaling pathway Growth hormone synthesis, secretion and action Huntington disease Tuberculosis Hepatitis B Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Viral carcinogenesis MicroRNAs in cancer Renal cell carcinoma Prostate cancer Regulation of gene expression by Hypoxia-inducible Factor RORA activates gene expression Polo-like kinase mediated events Pre-NOTCH Transcription and Translation PPARA activates gene expression Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production HATs acetylate histones Attenuation phase Transcriptional regulation of white adipocyte differentiation SUMOylation of transcription cofactors Circadian Clock B-WICH complex positively regulates rRNA expression CD209 (DC-SIGN) signaling Metalloprotease DUBs Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Methylation PI5P Regulates TP53 Acetylation Activation of the TFAP2 (AP-2) family of transcription factors RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known RUNX3 regulates NOTCH signaling Regulation of RUNX3 expression and activity RUNX3 regulates p14-ARF NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NGF-stimulated transcription TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Transcriptional regulation of granulopoiesis Regulation of FOXO transcriptional activity by acetylation +66 more

Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse EPH-ephrin mediated repulsion of cells +1 more

Endocrine resistance Hormone signaling Estrogen signaling pathway Prolactin signaling pathway Thyroid hormone signaling pathway Endocrine and other factor-regulated calcium reabsorption Pathways in cancer Proteoglycans in cancer Chemical carcinogenesis - receptor activation Breast cancer Nuclear signaling by ERBB4 PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Nuclear Receptor transcription pathway SUMOylation of intracellular receptors Ovarian tumor domain proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TFAP2 (AP-2) family regulates transcription of growth factors and their receptors RUNX1 regulates estrogen receptor mediated transcription ESR-mediated signaling RUNX1 regulates transcription of genes involved in WNT signaling Regulation of RUNX2 expression and activity Extra-nuclear estrogen signaling Estrogen-dependent gene expression +21 more

Transcriptional misregulation in cancer

Transcriptional misregulation in cancer

Glycosaminoglycan biosynthesis - heparan sulfate / heparin Metabolic pathways HS-GAG biosynthesis Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS +2 more

Lysine degradation Metabolic pathways Polycomb repressive complex MicroRNAs in cancer PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events +7 more

Tight junction Leukocyte transendothelial migration Regulation of actin cytoskeleton Gastric acid secretion Pathogenic Escherichia coli infection Proteoglycans in cancer MicroRNAs in cancer Netrin-1 signaling Recycling pathway of L1 +6 more

Fanconi anemia pathway Fanconi Anemia Pathway

Hippo signaling pathway - multiple species

Neddylation Antigen processing: Ubiquitination & Proteasome degradation

Ubiquitin mediated proteolysis Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Neddylation Antigen processing: Ubiquitination & Proteasome degradation +3 more

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Adherens junction Signaling pathways regulating pluripotency of stem cells Thermogenesis Regulation of actin cytoskeleton Parathyroid hormone synthesis, secretion and action Pathways in cancer Proteoglycans in cancer Prostate cancer Melanoma Breast cancer Central carbon metabolism in cancer PI3K Cascade PIP3 activates AKT signaling Signaling by FGFR1 amplification mutants Signaling by activated point mutants of FGFR1 FGFR1b ligand binding and activation FGFR1c ligand binding and activation FGFR1c and Klotho ligand binding and activation Constitutive Signaling by Aberrant PI3K in Cancer Signal transduction by L1 Phospholipase C-mediated cascade: FGFR1 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling Negative regulation of FGFR1 signaling Signaling by FGFR1 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by plasma membrane FGFR1 fusions +32 more

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway Endocytosis PI3K-Akt signaling pathway Signaling pathways regulating pluripotency of stem cells Regulation of actin cytoskeleton Pathways in cancer MicroRNAs in cancer Bladder cancer Central carbon metabolism in cancer PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR3 FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR3 mutant receptor activation t(4;14) translocations of FGFR3 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade; FGFR3 SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 Negative regulation of FGFR3 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer +27 more

mRNA surveillance pathway Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs Signaling by cytosolic PDGFRA and PDGFRB fusion proteins +4 more

MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway Hematopoietic cell lineage Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia Central carbon metabolism in cancer PI3K Cascade RAF/MAP kinase cascade FLT3 Signaling +8 more

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Focal adhesion Pathways in cancer Breast cancer VEGF binds to VEGFR leading to receptor dimerization +6 more

Estrogen-dependent gene expression

MicroRNAs in cancer Transcriptional regulation of pluripotent stem cells

Purine metabolism Drug metabolism - other enzymes Metabolic pathways Nucleotide metabolism Purine ribonucleoside monophosphate biosynthesis +2 more

Endocrine resistance Rap1 signaling pathway Calcium signaling pathway cAMP signaling pathway Phospholipase D signaling pathway Hormone signaling Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Gap junction Platelet activation Circadian entrainment Thermogenesis Glutamatergic synapse Serotonergic synapse Dopaminergic synapse Long-term depression Inflammatory mediator regulation of TRP channels Insulin secretion GnRH signaling pathway Ovarian steroidogenesis Estrogen signaling pathway Melanogenesis Thyroid hormone synthesis Oxytocin signaling pathway Glucagon signaling pathway Regulation of lipolysis in adipocytes Renin secretion Aldosterone synthesis and secretion Relaxin signaling pathway Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action Cushing syndrome Growth hormone synthesis, secretion and action Endocrine and other factor-regulated calcium reabsorption Vasopressin-regulated water reabsorption Salivary secretion Gastric acid secretion Pancreatic secretion Bile secretion Parkinson disease Cocaine addiction Amphetamine addiction Morphine addiction Alcoholism Vibrio cholerae infection Chagas disease Amoebiasis Human cytomegalovirus infection Human papillomavirus infection Pathways in cancer Chemical carcinogenesis - receptor activation Dilated cardiomyopathy Glucagon signaling in metabolic regulation PKA activation in glucagon signalling Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Prostacyclin signalling through prostacyclin receptor G alpha (s) signalling events Glucagon-type ligand receptors Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production +58 more

Folate biosynthesis Metabolic pathways Biosynthesis of cofactors GABAergic synapse Molybdenum cofactor biosynthesis +2 more

Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse Cocaine addiction G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) +3 more

Motor proteins

cGMP-PKG signaling pathway FoxO signaling pathway Hormone signaling Autophagy - animal AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Insulin signaling pathway Adipocytokine signaling pathway Regulation of lipolysis in adipocytes Type II diabetes mellitus Growth hormone synthesis, secretion and action Alzheimer disease IRS-related events triggered by IGF1R +11 more

Chemokine signaling pathway T cell receptor signaling pathway Leukocyte transendothelial migration Generation of second messenger molecules FCERI mediated Ca+2 mobilization +2 more

Signaling pathways regulating pluripotency of stem cells HATs acetylate histones Regulation of TP53 Activity through Acetylation

Circadian entrainment Retrograde endocannabinoid signaling Serotonergic synapse Dopaminergic synapse Estrogen signaling pathway Oxytocin signaling pathway Aldosterone synthesis and secretion GnRH secretion Morphine addiction Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits +8 more

HDMs demethylate histones

Transcriptional misregulation in cancer HDMs demethylate histones

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway VEGF signaling pathway Focal adhesion Proteoglycans in cancer Fluid shear stress and atherosclerosis Neurophilin interactions with VEGF and VEGFR VEGF binds to VEGFR leading to receptor dimerization Integrin cell surface interactions VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Signaling by membrane-tethered fusions of PDGFRA or PDGFRB +13 more

Ubiquitin mediated proteolysis Parkinson disease Pathways in cancer Chemical carcinogenesis - reactive oxygen species Hepatocellular carcinoma Fluid shear stress and atherosclerosis Ub-specific processing proteases Neddylation Antigen processing: Ubiquitination & Proteasome degradation +6 more

Lysine degradation Metabolic pathways Cushing syndrome Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function +4 more

EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway ErbB signaling pathway Ras signaling pathway Rap1 signaling pathway Chemokine signaling pathway FoxO signaling pathway Sphingolipid signaling pathway Phospholipase D signaling pathway Mitophagy - animal Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway Apoptosis Longevity regulating pathway Longevity regulating pathway - multiple species Cellular senescence Axon guidance VEGF signaling pathway Apelin signaling pathway Gap junction Signaling pathways regulating pluripotency of stem cells C-type lectin receptor signaling pathway Natural killer cell mediated cytotoxicity T cell receptor signaling pathway B cell receptor signaling pathway Fc epsilon RI signaling pathway Thermogenesis Long-term potentiation Neurotrophin signaling pathway Cholinergic synapse Serotonergic synapse Long-term depression Regulation of actin cytoskeleton Insulin signaling pathway GnRH signaling pathway Progesterone-mediated oocyte maturation Estrogen signaling pathway Melanogenesis Prolactin signaling pathway Thyroid hormone signaling pathway Oxytocin signaling pathway Relaxin signaling pathway GnRH secretion AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Aldosterone-regulated sodium reabsorption Alzheimer disease Pathways of neurodegeneration - multiple diseases Alcoholism Hepatitis C Hepatitis B Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection Pathways in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Glioma Prostate cancer Thyroid cancer Melanoma Bladder cancer Chronic myeloid leukemia Acute myeloid leukemia Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Lipid and atherosclerosis Activation of RAS in B cells Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB4 signaling Signaling by SCF-KIT p38MAPK events GRB2 events in EGFR signaling SHC1 events in EGFR signaling Downstream signal transduction GRB2 events in ERBB2 signaling Tie2 Signaling EGFR Transactivation by Gastrin DAP12 signaling FCERI mediated MAPK activation NCAM signaling for neurite out-growth Ca2+ pathway VEGFR2 mediated cell proliferation CD209 (DC-SIGN) signaling Constitutive Signaling by EGFRvIII SHC-mediated cascade:FGFR1 FRS-mediated FGFR1 signaling SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Regulation of RAS by GAPs RAF activation RAF/MAP kinase cascade MAP2K and MAPK activation Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions RAS signaling downstream of NF1 loss-of-function variants Paradoxical activation of RAF signaling by kinase inactive BRAF PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAS signaling Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer RUNX3 regulates p14-ARF FLT3 Signaling Constitutive Signaling by Overexpressed ERBB2 Estrogen-stimulated signaling through PRKCZ RAS GTPase cycle mutants Signaling downstream of RAS mutants Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants +134 more

Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo

Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo