Subtype of: Mesothelioma

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
pleural biphasic mesothelioma	MONDO_0006377	MECOM	Unknown	26928227	Open Targets	Lysine degradation Metabolic pathways MAPK signaling pathway +4 more
		MEN1	Unknown	28481359	Open Targets	Cushing syndrome Transcriptional misregulation in cancer Formation of the beta-catenin:TCF transactivating complex +5 more
		MET	Unknown	26928227	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MLH1	Unknown	26928227	Open Targets	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MUC16	Unknown	26928227	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC4	Unknown	26928227	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MYCN	Unknown	28481359	Open Targets	Transcriptional misregulation in cancer
		MYD88	Unknown	27127140	Open Targets	MAPK signaling pathway NF-kappa B signaling pathway Toll-like receptor signaling pathway +39 more
		MYH9	Unknown	26554828 26928227	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +8 more
		NF2	Unknown	23435014 27127140 25902174 25488749 28481359 26928227	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Tight junction +2 more
		NSD1	Unknown	28344893 26928227	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		NTHL1	Unknown	26928227	Open Targets	Base excision repair Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine +3 more
		NTRK1	Unknown	26928227	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +13 more
		NTRK3	Unknown	26928227	Open Targets	Calcium signaling pathway Neurotrophin signaling pathway Central carbon metabolism in cancer +4 more
		PDGFB	Unknown	26928227	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +25 more
		PIK3CA	Unknown	25174276 23558893	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3R2	Unknown	26928227	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +129 more
		PLCG1	Unknown	26928227	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +70 more
		PLEC	Unknown	26928227	Open Targets	Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins +1 more
		PPP6C	Unknown	28344893	Open Targets	COPII-mediated vesicle transport
		PRF1	Unknown	26928227	Open Targets	Apoptosis Natural killer cell mediated cytotoxicity Type I diabetes mellitus +4 more
		PRKAR1A	Unknown	26928227	Open Targets	Insulin signaling pathway PKA activation PKA activation in glucagon signalling +7 more
		PTCH1	Unknown	27127140	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTEN	Unknown	26928227	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		RAD17	Unknown	25488749	Open Targets	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends +3 more
		RAD50	Unknown	26928227	Open Targets	Homologous recombination Non-homologous end-joining Cellular senescence +14 more
		RANBP2	Unknown	25488749	Open Targets	Nucleocytoplasmic transport Viral life cycle - HIV-1 Amyotrophic lateral sclerosis +32 more
		RB1	Unknown	26928227	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		RICTOR	Unknown	28481359 26928227	Open Targets	mTOR signaling pathway PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling +3 more
		RNF43	Unknown	26554828	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation
		ROCK1	Unknown	25488749	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway +25 more
		SETD2	Unknown	26928227	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		SETDB1	Unknown	25488749 26928227	Open Targets	Lysine degradation Metabolic pathways Signaling pathways regulating pluripotency of stem cells +1 more
		SH2B3	Unknown	25488749	Open Targets	Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
		SMARCB1	Unknown	26928227	Open Targets	ATP-dependent chromatin remodeling Viral life cycle - HIV-1 Thermogenesis +3 more
		SMO	Unknown	23826113	Open Targets	Hedgehog signaling pathway Axon guidance Pathways in cancer +6 more
		SPECC1	Unknown	26928227	Open Targets	—
		SUFU	Unknown	26928227	Open Targets	Hedgehog signaling pathway Pathways in cancer Basal cell carcinoma +4 more
		TBL1XR1	Unknown	26928227	Open Targets	Wnt signaling pathway RORA activates gene expression PPARA activates gene expression +11 more
		TCF3	Unknown	26928227	Open Targets	Signaling pathways regulating pluripotency of stem cells Human T-cell leukemia virus 1 infection Transcriptional misregulation in cancer +2 more
		TET2	Unknown	26928227	Open Targets	—
		TGFBR2	Unknown	26928227	Open Targets	MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway +28 more
		TP53	Unknown	25174276 25488749 23435014 28481359 26928227	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TSC1	Unknown	26928227	Open Targets	Phospholipase D signaling pathway Autophagy - animal mTOR signaling pathway +15 more
		WNK2	Unknown	26928227	Open Targets	Parathyroid hormone synthesis, secretion and action Stimuli-sensing channels
		ZNF521	Unknown	26928227	Open Targets	—

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Pleural biphasic mesothelioma

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