Subtype of: Mesothelioma

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
pleural biphasic mesothelioma	MONDO_0006377	ACVR2A	Unknown	26928227	Open Targets	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells +3 more
		ALDH2	Unknown	26928227	Open Targets	Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Fatty acid degradation +14 more
		ALK	Unknown	26928227	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		APC	Unknown	25174276	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		ARID1A	Unknown	26928227	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		AXIN2	Unknown	28344893	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +15 more
		BAP1	Unknown	21642991 27127140 26928227 25488749 21874000 28481359 22321046	Open Targets	Polycomb repressive complex UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
		BCL11A	Unknown	26928227	Open Targets	—
		BCLAF1	Unknown	26928227	Open Targets	—
		BCR	Unknown	26928227	Open Targets	Pathways in cancer Chronic myeloid leukemia Signaling by cytosolic FGFR1 fusion mutants +2 more
		BIRC6	Unknown	26928227	Open Targets	Ubiquitin mediated proteolysis Autophagy - animal Apoptosis - multiple species
		BLM	Unknown	27127140	Open Targets	Homologous recombination Fanconi anemia pathway Processive synthesis on the C-strand of the telomere +10 more
		BRAF	Unknown	23558893	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +52 more
		BRCA1	Unknown	26928227	Open Targets	Platinum drug resistance Homologous recombination Fanconi anemia pathway +19 more
		BRCA2	Unknown	26928227	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		CALR	Unknown	26928227	Open Targets	Protein processing in endoplasmic reticulum Phagosome Efferocytosis +14 more
		CASP8	Unknown	26928227	Open Targets	Platinum drug resistance p53 signaling pathway Apoptosis +53 more
		CDKN2A	Unknown	23270897 20591913 12117769 11172613 27127140	Open Targets	Endocrine resistance Platinum drug resistance Cell cycle +33 more
		CLIP1	Unknown	26928227	Open Targets	mTOR signaling pathway Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids +5 more
		CPEB3	Unknown	28344893	Open Targets	Oocyte meiosis Progesterone-mediated oocyte maturation
		CREBBP	Unknown	26928227	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +52 more
		CTNNB1	Unknown	26928227	Open Targets	Rap1 signaling pathway Wnt signaling pathway Hippo signaling pathway +51 more
		DDX3X	Unknown	26928227	Open Targets	RIG-I-like receptor signaling pathway Hepatitis B Viral carcinogenesis +1 more
		ELF4	Unknown	28344893	Open Targets	—
		ERBB4	Unknown	26928227	Open Targets	MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway +22 more
		FAM135B	Unknown	26928227	Open Targets	—
		FAM47C	Unknown	26928227	Open Targets	—
		FANCD2	Unknown	26928227	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
		FANCF	Unknown	26928227	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway
		FAT4	Unknown	26928227	Open Targets	Hippo signaling pathway - multiple species
		FBXW7	Unknown	26928227	Open Targets	Ubiquitin mediated proteolysis Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling +3 more
		FGFR4	Unknown	25488749 26928227	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +20 more
		FLT4	Unknown	26928227	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +6 more
		GMPS	Unknown	26928227	Open Targets	Purine metabolism Drug metabolism - other enzymes Metabolic pathways +2 more
		GPC5	Unknown	26554828	Open Targets	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation +7 more
		GPHN	Unknown	26928227	Open Targets	Folate biosynthesis Metabolic pathways Biosynthesis of cofactors +2 more
		GRIN2A	Unknown	27127140 26928227	Open Targets	Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway +19 more
		IL2	Unknown	26928227	Open Targets	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor PI3K-Akt signaling pathway +21 more
		ITK	Unknown	25488749	Open Targets	Chemokine signaling pathway T cell receptor signaling pathway Leukocyte transendothelial migration +2 more
		KAT6B	Unknown	26928227	Open Targets	HATs acetylate histones
		KDM5C	Unknown	26928227	Open Targets	HDMs demethylate histones
		KMT2C	Unknown	26928227	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KRAS	Unknown	23558893	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LATS1	Unknown	26928227	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LATS2	Unknown	25902174 26928227	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LCK	Unknown	26928227	Open Targets	NF-kappa B signaling pathway Osteoclast differentiation Natural killer cell mediated cytotoxicity +27 more
		LCP1	Unknown	26928227	Open Targets	Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
		LIFR	Unknown	26928227	Open Targets	Cytokine-cytokine receptor interaction Signaling pathways regulating pluripotency of stem cells JAK-STAT signaling pathway +2 more
		LRP1B	Unknown	26928227	Open Targets	—
		MDM2	Unknown	26928227	Open Targets	Endocrine resistance Platinum drug resistance FoxO signaling pathway +35 more

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Pleural biphasic mesothelioma

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