Subtype of: Pancreatic neoplasms

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
pancreatic neuroendocrine tumor	MONDO_0019954	KMT2D	Unknown	29092957 32586046 28481359	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KNL1	Unknown	32586046	Open Targets	Cell cycle Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids +5 more
		KRAS	Unknown	28481359 12802288 10777194 27705932 14506146 27262570	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LATS1	Unknown	28481359	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LATS2	Unknown	28481359 21252315	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LRP1B	Unknown	26087898	Open Targets	—
		MAP2K1	Unknown	32586046	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +99 more
		MAP2K4	Unknown	28481359	Open Targets	MAPK signaling pathway ErbB signaling pathway Toll-like receptor signaling pathway +21 more
		MAP3K1	Unknown	29092957	Open Targets	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MAP3K13	Unknown	29092957	Open Targets	MAPK signaling pathway
		MAX	Unknown	28481359	Open Targets	Polycomb repressive complex MAPK signaling pathway Pathways in cancer +6 more
		MED12	Unknown	28481359	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MEN1	Unknown	32586046 28179320 32561076 9895334 29092957 20403035 21252315 27994516 28481359	Open Targets	Cushing syndrome Transcriptional misregulation in cancer Formation of the beta-catenin:TCF transactivating complex +5 more
		MET	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MITF	Unknown	32586046	Open Targets	Mitophagy - animal Osteoclast differentiation Melanogenesis +4 more
		MLH1	Unknown	29092957 28481359	Open Targets	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MLLT1	Unknown	29092957	Open Targets	Viral life cycle - HIV-1 Transcriptional misregulation in cancer Formation of RNA Pol II elongation complex +2 more
		MLLT10	Unknown	32586046	Open Targets	—
		MSH2	Unknown	28481359	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +7 more
		MSH6	Unknown	29092957 32586046 28481359	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +4 more
		MTOR	Unknown	27994516 32586046 29092957 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MUC16	Unknown	29092957	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MUC4	Unknown	29092957	Open Targets	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) +3 more
		MYC	Unknown	21252315	Open Targets	MAPK signaling pathway ErbB signaling pathway Cell cycle +45 more
		MYCN	Unknown	28481359	Open Targets	Transcriptional misregulation in cancer
		MYD88	Unknown	32586046 28481359	Open Targets	MAPK signaling pathway NF-kappa B signaling pathway Toll-like receptor signaling pathway +39 more
		MYH11	Unknown	26087898	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +6 more
		NCOR1	Unknown	28481359	Open Targets	Endocrine resistance TGF-beta signaling pathway Thyroid hormone signaling pathway +16 more
		NF1	Unknown	27994516 21252315 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NFKB2	Unknown	32586046	Open Targets	MAPK signaling pathway NF-kappa B signaling pathway Osteoclast differentiation +19 more
		NIN	Unknown	32586046	Open Targets	—
		NKX2-1	Unknown	28481359	Open Targets	—
		NOTCH1	Unknown	29092957 28481359	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NOTCH2	Unknown	32586046 28481359	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NRAS	Unknown	7952399 9042254 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NSD1	Unknown	28481359	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		NTRK1	Unknown	32586046	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +13 more
		NTRK2	Unknown	28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +6 more
		PAX5	Unknown	26087898	Open Targets	Transcriptional misregulation in cancer RUNX1 regulates transcription of genes involved in BCR signaling
		PAX7	Unknown	32586046	Open Targets	Transcriptional misregulation in cancer
		PHOX2B	Unknown	29092957	Open Targets	—
		PIK3CA	Unknown	27994516 22437754 21252315 21447618	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3R3	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +116 more
		PLEC	Unknown	29092957	Open Targets	Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins +1 more
		PMS1	Unknown	32586046	Open Targets	—
		POLE	Unknown	28481359	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		PPP2R1A	Unknown	28481359	Open Targets	mRNA surveillance pathway Sphingolipid signaling pathway Cell cycle +52 more
		PPP6C	Unknown	28481359	Open Targets	COPII-mediated vesicle transport
		PRDM1	Unknown	28481359	Open Targets	Regulation of TP53 Expression
		PRKAR1A	Unknown	28481359	Open Targets	Insulin signaling pathway PKA activation PKA activation in glucagon signalling +7 more

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Pancreatic neuroendocrine tumor

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