Subtype of: Ovarian cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
ovarian clear cell adenocarcinoma	MONDO_0006045	RB1	Unknown	26920370 33947352	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		RECQL4	Unknown	28481359 33947352	Open Targets	—
		REL	Unknown	33947352	Open Targets	Ras signaling pathway Transcriptional misregulation in cancer Viral carcinogenesis +1 more
		RET	Unknown	28481359 33947352	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		RICTOR	Unknown	28481359	Open Targets	mTOR signaling pathway PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling +3 more
		RNF213	Unknown	33947352	Open Targets	Suppression of apoptosis Antigen processing: Ubiquitination & Proteasome degradation
		RNF43	Unknown	28481359 29986747	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation
		ROS1	Unknown	33947352	Open Targets	—
		SDHA	Unknown	33947352	Open Targets	Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways +12 more
		SEPTIN9	Unknown	33947352	Open Targets	Bacterial invasion of epithelial cells Shigellosis
		SETD2	Unknown	33947352	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		SF3B1	Unknown	27939411	Open Targets	Spliceosome B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway +1 more
		SGK1	Unknown	33947352	Open Targets	FoxO signaling pathway Efferocytosis mTOR signaling pathway +6 more
		SMAD3	Unknown	28481359 20826764	Open Targets	FoxO signaling pathway Cell cycle Endocytosis +34 more
		SMAD4	Unknown	10451707	Open Targets	FoxO signaling pathway Hormone signaling Cell cycle +30 more
		SMARCA4	Unknown	27939411 28481359 23791828 20826764	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +6 more
		SMO	Unknown	33947352	Open Targets	Hedgehog signaling pathway Axon guidance Pathways in cancer +6 more
		SPOP	Unknown	28481359 29986747 20826764	Open Targets	Hedgehog signaling pathway Hedgehog 'on' state
		STAT3	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway HIF-1 signaling pathway +53 more
		STK11	Unknown	10429654 33947352	Open Targets	FoxO signaling pathway Hormone signaling Autophagy - animal +9 more
		SUFU	Unknown	26920370	Open Targets	Hedgehog signaling pathway Pathways in cancer Basal cell carcinoma +4 more
		TAL1	Unknown	33947352	Open Targets	RUNX1 regulates transcription of genes involved in differentiation of HSCs
		TBX3	Unknown	28481359	Open Targets	Signaling pathways regulating pluripotency of stem cells
		TET1	Unknown	28481359 33947352	Open Targets	—
		TFE3	Unknown	33947352	Open Targets	Mitophagy - animal Transcriptional misregulation in cancer Renal cell carcinoma
		TGFBR2	Unknown	33947352 29986747	Open Targets	MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway +28 more
		TOP1	Unknown	20826764	Open Targets	SUMOylation of DNA replication proteins
		TP53	Unknown	15221786 25846551 28481359 11595686 9550561 33947352 23791828 15099937 25846456 8319218 16211227 33292376 16459017 7852189 20826764	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TPR	Unknown	33947352	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Pathways in cancer +27 more
		TRIM33	Unknown	33947352	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity
		TRIP11	Unknown	33947352	Open Targets	Intraflagellar transport Intra-Golgi traffic
		TRRAP	Unknown	33947352	Open Targets	ATP-dependent chromatin remodeling Human T-cell leukemia virus 1 infection Formation of the beta-catenin:TCF transactivating complex +1 more
		TSC1	Unknown	33947352	Open Targets	Phospholipase D signaling pathway Autophagy - animal mTOR signaling pathway +15 more
		TSC2	Unknown	33947352	Open Targets	Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal +19 more
		UBR5	Unknown	33947352	Open Targets	Ubiquitin mediated proteolysis
		USP9X	Unknown	33947352	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes +2 more
		WRN	Unknown	33947352	Open Targets	Processive synthesis on the C-strand of the telomere Removal of the Flap Intermediate from the C-strand SUMOylation of DNA damage response and repair proteins +9 more
		ZFHX3	Unknown	28481359	Open Targets	Signaling pathways regulating pluripotency of stem cells RUNX3 regulates CDKN1A transcription
		ZNF521	Unknown	33947352	Open Targets	—

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Ovarian clear cell adenocarcinoma

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