Subtype of: Melanoma

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
nodular malignant melanoma	MONDO_0000930	STAT6	Unknown	26359337	Open Targets	Necroptosis JAK-STAT signaling pathway Th1 and Th2 cell differentiation +7 more
		STIL	Unknown	33024263 26359337 30178487	Open Targets	—
		STK11	Unknown	36219477 30178487 28870692	Open Targets	FoxO signaling pathway Hormone signaling Autophagy - animal +9 more
		STRN	Unknown	33024263	Open Targets	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling +2 more
		SUFU	Unknown	26359337 36219477	Open Targets	Hedgehog signaling pathway Pathways in cancer Basal cell carcinoma +4 more
		SYK	Unknown	22197931 33024263 36219477 26359337	Open Targets	NF-kappa B signaling pathway Phospholipase D signaling pathway PI3K-Akt signaling pathway +30 more
		TAL1	Unknown	33024263	Open Targets	RUNX1 regulates transcription of genes involved in differentiation of HSCs
		TBL1XR1	Unknown	36219477 26359337	Open Targets	Wnt signaling pathway RORA activates gene expression PPARA activates gene expression +11 more
		TBX3	Unknown	36219477	Open Targets	Signaling pathways regulating pluripotency of stem cells
		TCF12	Unknown	33024263 36219477 26359337	Open Targets	Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs NGF-stimulated transcription
		TCF3	Unknown	33024263	Open Targets	Signaling pathways regulating pluripotency of stem cells Human T-cell leukemia virus 1 infection Transcriptional misregulation in cancer +2 more
		TCF7L2	Unknown	33024263 36219477	Open Targets	Wnt signaling pathway Hippo signaling pathway Adherens junction +26 more
		TCL1A	Unknown	33024263 26359337	Open Targets	PI3K-Akt signaling pathway
		TEC	Unknown	33024263 30178487	Open Targets	Osteoclast differentiation T cell receptor signaling pathway Signaling by SCF-KIT +2 more
		TENT5C	Unknown	26359337	Open Targets	—
		TERT	Unknown	33024263 36219477 26359337	Open Targets	Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer +4 more
		TET1	Unknown	33024263 26359337 30178487	Open Targets	—
		TET2	Unknown	33024263 36219477 30178487 26359337	Open Targets	—
		TFE3	Unknown	33024263 30178487	Open Targets	Mitophagy - animal Transcriptional misregulation in cancer Renal cell carcinoma
		TFEB	Unknown	22197931 33024263 26359337 30178487	Open Targets	Calcium signaling pathway Mitophagy - animal
		TFG	Unknown	33024263	Open Targets	Pathways in cancer Thyroid cancer COPII-mediated vesicle transport
		TGFBR2	Unknown	33024263 36219477 30178487	Open Targets	MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway +28 more
		THRAP3	Unknown	33024263 30178487	Open Targets	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation
		TLX1	Unknown	33024263 26359337	Open Targets	Transcriptional misregulation in cancer
		TLX3	Unknown	33024263	Open Targets	Transcriptional misregulation in cancer
		TMEM127	Unknown	26359337	Open Targets	—
		TNC	Unknown	33024263 26359337 30178487	Open Targets	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +6 more
		TNFAIP3	Unknown	26359337	Open Targets	NF-kappa B signaling pathway Necroptosis NOD-like receptor signaling pathway +10 more
		TNRC18	Unknown	33024263 26359337 30178487	Open Targets	—
		TOP1	Unknown	33024263 26359337 30178487	Open Targets	SUMOylation of DNA replication proteins
		TP53	Unknown	33024263 36219477 30178487 10070891 22197931 26359337	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TP63	Unknown	22197931 33024263 26359337 30178487	Open Targets	MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes +5 more
		TPM3	Unknown	26359337	Open Targets	Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Motor proteins +7 more
		TPR	Unknown	33024263 36219477 30178487	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis Pathways in cancer +27 more
		TRAF7	Unknown	33024263 36219477 26359337	Open Targets	Antigen processing: Ubiquitination & Proteasome degradation
		TRIM24	Unknown	26359337 30178487	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF fusions
		TRIM27	Unknown	33024263	Open Targets	SUMOylation of ubiquitinylation proteins Regulation of PTEN stability and activity Suppression of apoptosis
		TRIM33	Unknown	26359337 30178487	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity
		TRIP11	Unknown	33024263 30178487	Open Targets	Intraflagellar transport Intra-Golgi traffic
		TRRAP	Unknown	33024263 36219477 30178487 26359337	Open Targets	ATP-dependent chromatin remodeling Human T-cell leukemia virus 1 infection Formation of the beta-catenin:TCF transactivating complex +1 more
		TSC1	Unknown	26359337 36219477	Open Targets	Phospholipase D signaling pathway Autophagy - animal mTOR signaling pathway +15 more
		TSC2	Unknown	22197931 33024263 26359337 36219477	Open Targets	Phospholipase D signaling pathway p53 signaling pathway Autophagy - animal +19 more
		TSHR	Unknown	22197931 26359337	Open Targets	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +6 more
		U2AF1	Unknown	26359337 30178487 36219477	Open Targets	Spliceosome Shigellosis Transport of Mature mRNA derived from an Intron-Containing Transcript +3 more
		UBR5	Unknown	22197931 26359337 36219477	Open Targets	Ubiquitin mediated proteolysis
		USP44	Unknown	26359337	Open Targets	Ub-specific processing proteases
		USP6	Unknown	33024263 36219477 26359337	Open Targets	—
		USP8	Unknown	33024263	Open Targets	Mitophagy - animal Endocytosis Cushing syndrome +4 more
		USP9X	Unknown	33024263 36219477 30178487	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes +2 more
		VAV1	Unknown	33024263 26359337 30178487	Open Targets	Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway +30 more

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Nodular malignant melanoma

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