Subtype of: Melanoma

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
nodular malignant melanoma	MONDO_0000930	PRCC	Unknown	33024263	Open Targets	Transcriptional misregulation in cancer Renal cell carcinoma mRNA Splicing - Major Pathway
		PRDM1	Unknown	33024263 36219477 30178487	Open Targets	Regulation of TP53 Expression
		PRDM16	Unknown	33024263 26359337 30178487	Open Targets	Lysine degradation Metabolic pathways Thermogenesis +1 more
		PRDM2	Unknown	33024263 26359337 36219477	Open Targets	Lysine degradation Metabolic pathways
		PREX2	Unknown	33024263 36219477 30178487 22197931 22622578 26359337 28356599	Open Targets	Regulation of PTEN stability and activity
		PRF1	Unknown	33024263 30178487	Open Targets	Apoptosis Natural killer cell mediated cytotoxicity Type I diabetes mellitus +4 more
		PRKACA	Unknown	33024263 26359337 30178487	Open Targets	Endocrine resistance MAPK signaling pathway Ras signaling pathway +95 more
		PRKAR1A	Unknown	33024263 26359337 30178487 36219477	Open Targets	Insulin signaling pathway PKA activation PKA activation in glucagon signalling +7 more
		PRKCB	Unknown	33024263 26359337 30178487	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +77 more
		PRPF40B	Unknown	33024263	Open Targets	Spliceosome
		PSIP1	Unknown	33024263 36219477	Open Targets	Viral life cycle - HIV-1 Integration of provirus 2-LTR circle formation +4 more
		PTCH1	Unknown	33024263 26359337 36219477	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTEN	Unknown	10881743 33024263 36219477 30178487 20544847 26359337 11297763	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTK6	Unknown	33024263	Open Targets	SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1 ERBB2 Activates PTK6 Signaling +8 more
		PTPN11	Unknown	26359337 30178487 36219477	Open Targets	Ras signaling pathway Phospholipase D signaling pathway Efferocytosis +56 more
		PTPN13	Unknown	33024263 26359337 30178487	Open Targets	Apoptosis Synthesis of PIPs at the plasma membrane Interleukin-37 signaling
		PTPN6	Unknown	26359337 30178487	Open Targets	Efferocytosis Adherens junction JAK-STAT signaling pathway +22 more
		PTPRB	Unknown	33024263 26359337 30178487 36219477	Open Targets	Adherens junction Neutrophil degranulation
		PTPRC	Unknown	22197931 33024263 26359337 30178487	Open Targets	Cell adhesion molecules T cell receptor signaling pathway Fc gamma R-mediated phagocytosis +5 more
		PTPRD	Unknown	33024263 26359337 30178487	Open Targets	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
		PTPRK	Unknown	33024263 36219477 30178487 26359337	Open Targets	EGFR downregulation
		PTPRT	Unknown	33024263 26359337 30178487	Open Targets	—
		QKI	Unknown	33024263 36219477	Open Targets	Signaling by BRAF and RAF fusions
		RABEP1	Unknown	33024263 30178487	Open Targets	Endocytosis TBC/RABGAPs
		RAC1	Unknown	25043693 33024263 36219477 30178487 28356599	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +89 more
		RAD17	Unknown	26359337 30178487	Open Targets	Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends +3 more
		RAD21	Unknown	26359337 36219477	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		RAD51	Unknown	30178487	Open Targets	Homologous recombination Fanconi anemia pathway Pathways in cancer +8 more
		RAD51B	Unknown	33024263 26359337	Open Targets	Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) +4 more
		RAD51C	Unknown	36219477 30178487	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +5 more
		RAD51D	Unknown	26359337	Open Targets	Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) +4 more
		RAF1	Unknown	26359337 36219477	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +93 more
		RALGDS	Unknown	26359337	Open Targets	Ras signaling pathway Rap1 signaling pathway Phospholipase D signaling pathway +5 more
		RANBP2	Unknown	33024263 26359337	Open Targets	Nucleocytoplasmic transport Viral life cycle - HIV-1 Amyotrophic lateral sclerosis +32 more
		RAP1B	Unknown	36219477	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +25 more
		RARA	Unknown	26359337	Open Targets	Th17 cell differentiation Estrogen signaling pathway Pathways in cancer +6 more
		RASA1	Unknown	36219477 26359337	Open Targets	MAPK signaling pathway Ras signaling pathway Axon guidance +5 more
		RB1	Unknown	33024263 36219477 30178487 26359337	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		RBM10	Unknown	33024263 36219477 26359337	Open Targets	—
		RBM15	Unknown	33024263 26359337 30178487	Open Targets	—
		RECQL4	Unknown	33024263 26359337 30178487	Open Targets	—
		RET	Unknown	33024263 26359337 30178487 37569660 36219477	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		RFWD3	Unknown	22197931 33024263 26359337	Open Targets	—
		RGPD3	Unknown	26359337 30178487	Open Targets	—
		RGS7	Unknown	33024263 36219477 30178487 22197931 26359337	Open Targets	G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
		RHOA	Unknown	36219477 30178487	Open Targets	Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway +64 more
		RHOH	Unknown	33024263	Open Targets	Leukocyte transendothelial migration Salmonella infection Rho GTPase cycle
		RICTOR	Unknown	33024263 26359337 30178487	Open Targets	mTOR signaling pathway PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling +3 more
		RMI2	Unknown	26359337 30178487 36219477	Open Targets	Fanconi anemia pathway HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) +7 more
		RNF213	Unknown	33024263 26359337 30178487	Open Targets	Suppression of apoptosis Antigen processing: Ubiquitination & Proteasome degradation

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Nodular malignant melanoma

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