Nodal marginal zone b-cell lymphoma

Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells Signaling by Activin +1 more

Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer

NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events

Transcriptional misregulation in cancer

Platinum drug resistance Homologous recombination NF-kappa B signaling pathway FoxO signaling pathway Cell cycle p53 signaling pathway Apoptosis Cellular senescence Shigellosis Human papillomavirus infection Human T-cell leukemia virus 1 infection Human immunodeficiency virus 1 infection Transcriptional misregulation in cancer MicroRNAs in cancer DNA Damage/Telomere Stress Induced Senescence Regulation of HSF1-mediated heat shock response Autodegradation of the E3 ubiquitin ligase COP1 HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 Regulates Transcription of Caspase Activators and Caspases Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation Regulation of TP53 Activity through Methylation G2/M DNA damage checkpoint Stabilization of p53 Pexophagy +33 more

Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Adrenergic signaling in cardiomyocytes Aldosterone synthesis and secretion Endocrine and other factor-regulated calcium reabsorption Salivary secretion Pancreatic secretion Mineral absorption Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases +9 more

NF-kappa B signaling pathway C-type lectin receptor signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway Shigellosis Tuberculosis Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling E3 ubiquitin ligases ubiquitinate target proteins +8 more

EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance NF-kappa B signaling pathway HIF-1 signaling pathway Sphingolipid signaling pathway p53 signaling pathway Autophagy - animal Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Apoptosis Apoptosis - multiple species Necroptosis Adrenergic signaling in cardiomyocytes Hedgehog signaling pathway Focal adhesion NOD-like receptor signaling pathway JAK-STAT signaling pathway Neurotrophin signaling pathway Cholinergic synapse Estrogen signaling pathway Parathyroid hormone synthesis, secretion and action AGE-RAGE signaling pathway in diabetic complications Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Shigellosis Salmonella infection Toxoplasmosis Tuberculosis Hepatitis B Measles Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Colorectal cancer Prostate cancer Small cell lung cancer Gastric cancer Lipid and atherosclerosis Fluid shear stress and atherosclerosis Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling +46 more

ATP-dependent chromatin remodeling

Ubiquitin mediated proteolysis Autophagy - animal Apoptosis - multiple species

EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway ErbB signaling pathway Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway FoxO signaling pathway mTOR signaling pathway Vascular smooth muscle contraction Focal adhesion Natural killer cell mediated cytotoxicity Long-term potentiation Neurotrophin signaling pathway Serotonergic synapse Long-term depression Regulation of actin cytoskeleton Insulin signaling pathway Progesterone-mediated oocyte maturation Parathyroid hormone synthesis, secretion and action Cushing syndrome Alzheimer disease Pathways of neurodegeneration - multiple diseases Alcoholism Hepatitis C Hepatitis B Pathways in cancer Proteoglycans in cancer Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Glioma Prostate cancer Thyroid cancer Melanoma Bladder cancer Chronic myeloid leukemia Acute myeloid leukemia Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Spry regulation of FGF signaling Frs2-mediated activation RAF activation MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants +52 more

RNA degradation FOXO-mediated transcription of cell cycle genes

NF-kappa B signaling pathway Osteoclast differentiation Platelet activation B cell receptor signaling pathway Fc epsilon RI signaling pathway Epstein-Barr virus infection Primary immunodeficiency ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Regulation of actin dynamics for phagocytic cup formation DAP12 signaling FCERI mediated Ca+2 mobilization G alpha (q) signalling events G alpha (12/13) signalling events MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) RHO GTPases Activate WASPs and WAVEs G beta:gamma signalling through BTK FCGR3A-mediated phagocytosis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers +17 more

NF-kappa B signaling pathway T cell receptor signaling pathway B cell receptor signaling pathway Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling +4 more

B cell receptor signaling pathway Primary immunodeficiency CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers +1 more

B cell receptor signaling pathway CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway HIF-1 signaling pathway FoxO signaling pathway Cell cycle Wnt signaling pathway Notch signaling pathway TGF-beta signaling pathway Adherens junction JAK-STAT signaling pathway Long-term potentiation Melanogenesis Thyroid hormone signaling pathway Glucagon signaling pathway Growth hormone synthesis, secretion and action Huntington disease Tuberculosis Hepatitis B Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Viral carcinogenesis MicroRNAs in cancer Renal cell carcinoma Prostate cancer Regulation of gene expression by Hypoxia-inducible Factor RORA activates gene expression Pre-NOTCH Transcription and Translation PPARA activates gene expression Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Attenuation phase Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Circadian Clock CD209 (DC-SIGN) signaling TP53 Regulates Transcription of Genes Involved in Cytochrome C Release Activation of the TFAP2 (AP-2) family of transcription factors RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Estrogen-dependent gene expression TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation Regulation of FOXO transcriptional activity by acetylation +52 more

Viral life cycle - HIV-1 Virion - Human immunodeficiency virus Calcium signaling pathway Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway Endocytosis Axon guidance Leukocyte transendothelial migration Intestinal immune network for IgA production Regulation of actin cytoskeleton Human cytomegalovirus infection Human immunodeficiency virus 1 infection Pathways in cancer Binding and entry of HIV virion Signaling by ROBO receptors Chemokine receptors bind chemokines G alpha (i) signalling events +15 more

Non-integrin membrane-ECM interactions

Cysteine and methionine metabolism Metabolic pathways Efferocytosis MicroRNAs in cancer PRC2 methylates histones and DNA RMTs methylate histone arginines +3 more

Transcriptional misregulation in cancer Prostate cancer

Lysine degradation Metabolic pathways Polycomb repressive complex MicroRNAs in cancer PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events +7 more

Platinum drug resistance MAPK signaling pathway Cytokine-cytokine receptor interaction p53 signaling pathway Apoptosis Necroptosis Natural killer cell mediated cytotoxicity TNF signaling pathway Non-alcoholic fatty liver disease Alcoholic liver disease Type I diabetes mellitus Alzheimer disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Chagas disease African trypanosomiasis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer Proteoglycans in cancer Autoimmune thyroid disease Allograft rejection Graft-versus-host disease Lipid and atherosclerosis Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TP53 Regulates Transcription of Death Receptors and Ligands Dimerization of procaspase-8 FasL/ CD95L signaling +36 more

Purine metabolism Metabolic pathways Small cell lung cancer Non-small cell lung cancer +1 more

mRNA surveillance pathway Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs Signaling by cytosolic PDGFRA and PDGFRB fusion proteins +4 more

MAPK signaling pathway Focal adhesion Salmonella infection Proteoglycans in cancer Platelet degranulation GP1b-IX-V activation signalling Cell-extracellular matrix interactions RHO GTPases activate PAKs OAS antiviral response +6 more

FoxO signaling pathway AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Cellular senescence Insulin signaling pathway Thyroid hormone signaling pathway Glucagon signaling pathway Insulin resistance AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Shigellosis Human papillomavirus infection Pathways in cancer Transcriptional misregulation in cancer Prostate cancer AKT phosphorylates targets in the nucleus AKT-mediated inactivation of FOXO1A Constitutive Signaling by AKT1 E17K in Cancer MAPK6/MAPK4 signaling Interleukin-4 and Interleukin-13 signaling Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation FOXO-mediated transcription of cell cycle genes +23 more

mRNA surveillance pathway Spliceosome Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Transcriptional misregulation in cancer mRNA Splicing - Major Pathway +3 more

Endocytosis Phagosome Cellular senescence Cell adhesion molecules Antigen processing and presentation Natural killer cell mediated cytotoxicity Type I diabetes mellitus Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Viral carcinogenesis Autoimmune thyroid disease Allograft rejection Graft-versus-host disease Viral myocarditis ER-Phagosome pathway Endosomal/Vacuolar pathway Nef mediated downregulation of MHC class I complex cell surface expression Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation Interferon gamma signaling E3 ubiquitin ligases ubiquitinate target proteins Interferon alpha/beta signaling Antigen Presentation: Folding, assembly and peptide loading of class I MHC +25 more

Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Interferon alpha/beta signaling +1 more

HATs acetylate histones

Signaling by BRAF and RAF fusions

Lysine degradation Metabolic pathways Cushing syndrome Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function +4 more

Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo

Lysine degradation Metabolic pathways MAPK signaling pathway Pathways in cancer Chronic myeloid leukemia PKMTs methylate histone lysines Regulation of PTEN gene transcription +4 more

Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis +3 more

Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis +3 more

MAPK signaling pathway NF-kappa B signaling pathway Toll-like receptor signaling pathway NOD-like receptor signaling pathway Alcoholic liver disease Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Legionellosis Yersinia infection Leishmaniasis Chagas disease African trypanosomiasis Malaria Toxoplasmosis Tuberculosis Hepatitis B Measles Influenza A Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 PD-L1 expression and PD-1 checkpoint pathway in cancer Lipid and atherosclerosis ER-Phagosome pathway PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane RIP-mediated NFkB activation via ZBP1 p75NTR recruits signalling complexes DEx/H-box helicases activate type I IFN and inflammatory cytokines production MyD88 deficiency (TLR2/4) MyD88 deficiency (TLR5) IRAK4 deficiency (TLR5) IRAK4 deficiency (TLR2/4) PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane +39 more

Spinocerebellar ataxia Myogenesis

Parathyroid hormone synthesis, secretion and action

Notch signaling pathway Epstein-Barr virus infection PPARA activates gene expression Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis +11 more

Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation Thyroid hormone signaling pathway Prion disease Human papillomavirus infection Pathways in cancer MicroRNAs in cancer Breast cancer Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi NOTCH1 Intracellular Domain Regulates Transcription Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway Defective LFNG causes SCDO3 RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription +20 more

Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation +2 more

mRNA surveillance pathway RNA degradation L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) +5 more

Transcriptional misregulation in cancer RUNX1 regulates transcription of genes involved in BCR signaling

Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance ErbB signaling pathway Ras signaling pathway Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway HIF-1 signaling pathway FoxO signaling pathway Phosphatidylinositol signaling system Sphingolipid signaling pathway Phospholipase D signaling pathway Hormone signaling Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Apoptosis Longevity regulating pathway Longevity regulating pathway - multiple species Cellular senescence Axon guidance VEGF signaling pathway Osteoclast differentiation Focal adhesion Signaling pathways regulating pluripotency of stem cells Platelet activation Neutrophil extracellular trap formation Toll-like receptor signaling pathway C-type lectin receptor signaling pathway JAK-STAT signaling pathway Natural killer cell mediated cytotoxicity T cell receptor signaling pathway B cell receptor signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis TNF signaling pathway Leukocyte transendothelial migration Neurotrophin signaling pathway Cholinergic synapse Inflammatory mediator regulation of TRP channels Regulation of actin cytoskeleton Insulin signaling pathway Progesterone-mediated oocyte maturation Estrogen signaling pathway Prolactin signaling pathway Thyroid hormone signaling pathway Regulation of lipolysis in adipocytes Relaxin signaling pathway GnRH secretion Type II diabetes mellitus Insulin resistance Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Aldosterone-regulated sodium reabsorption Carbohydrate digestion and absorption Alzheimer disease Spinocerebellar ataxia Prion disease Bacterial invasion of epithelial cells Shigellosis Salmonella infection Yersinia infection Chagas disease Amoebiasis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Glioma Prostate cancer Melanoma Chronic myeloid leukemia Acute myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade PIP3 activates AKT signaling Synthesis of PIPs at the plasma membrane Downstream signal transduction PI3K/AKT activation Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling RET signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Interleukin receptor SHC signaling Regulation of signaling by CBL Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants +126 more