Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
neurodegenerative disease	MONDO_0005559 MONDO:0005559 MONDO_0008695	HPDL	Unknown	32707086	Open Targets	—
		IRF2BPL	Unknown	30057031 30166628 31432588 31583567 31621620 32427350 34864472 36127562 36810721 37114479 37346291	CTD, ClinGen	—
		VPS13A	Unknown	11381253	Open Targets	—
Neurodegenerative diseases	MESH:D019636	AGPAT3	Unknown	15964507	CTD	Glycerolipid metabolism Glycerophospholipid metabolism Metabolic pathways +3 more
		APOD	Unknown	18458334	CTD	Transport of fatty acids NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
		APP	Unknown	16122394 23541064	CTD	Serotonergic synapse Alzheimer disease Pathways of neurodegeneration - multiple diseases +16 more
		ATXN1	Unknown	28182653	CTD	Notch signaling pathway Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases
		CRYAB	Unknown	15964507	CTD	Protein processing in endoplasmic reticulum Longevity regulating pathway - multiple species HSF1-dependent transactivation
		EPO	Unknown	15816862	CTD	Cytokine-cytokine receptor interaction HIF-1 signaling pathway Hormone signaling +8 more
		FTH1	Unknown	15964507	CTD	Porphyrin metabolism Ferroptosis Necroptosis +4 more
		GDNF	Unknown	11592846	CTD	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +2 more
		GPX3	Unknown	15964507	CTD	Glutathione metabolism Metabolic pathways Thyroid hormone synthesis +4 more
		GSR	Unknown	15964507	CTD	Glutathione metabolism Metabolic pathways Thyroid hormone synthesis +4 more
		GSTM1	Unknown	15964507	CTD	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +10 more
		GSTM2	Unknown	15964507	CTD	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +10 more
		GSTM4	Unknown	15964507	CTD	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +11 more
		GSTM5	Unknown	15964507	CTD	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +10 more
		GSTO1	Unknown	15964507	CTD	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +13 more
		HCRT	Unknown	23246865	CTD	Neuroactive ligand-receptor interaction Hormone signaling Orexin and neuropeptides FF and QRFP bind to their respective receptors +1 more
		HMOX1	Unknown	10942521 12709579 15964507	CTD	Porphyrin metabolism Metabolic pathways HIF-1 signaling pathway +11 more
		IDO1	Unknown	16365156	CTD	Tryptophan metabolism Metabolic pathways Biosynthesis of cofactors +2 more
		IL6	Unknown	12836160	CTD	EGFR tyrosine kinase inhibitor resistance Antifolate resistance Cytokine-cytokine receptor interaction +59 more
		KYNU	Unknown	16365156	CTD	Tryptophan metabolism Metabolic pathways Biosynthesis of cofactors +1 more
		MAPT	Unknown	9789048	CTD	MAPK signaling pathway Alzheimer disease Parkinson disease +2 more
		MGST1	Unknown	15964507	CTD	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +12 more
		NGF	Unknown	24244623	CTD	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +18 more
		NGFR	Unknown	12097334	CTD	Virion - Ebolavirus, Lyssavirus and Morbillivirus MAPK signaling pathway Ras signaling pathway +14 more
		PANK2	Unknown	16450344 17296847	CTD	Pantothenate and CoA biosynthesis Metabolic pathways Biosynthesis of cofactors +1 more
		PDE8B	Unknown	20085714	CTD	Purine metabolism Metabolic pathways Cortisol synthesis and secretion +3 more
		PKD2	Unknown	25013951	CTD	VxPx cargo-targeting to cilium
		PSEN1	Unknown	23541064	CTD	Wnt signaling pathway Notch signaling pathway Neurotrophin signaling pathway +12 more
		SELENOP	Unknown	15964507	CTD	Platelet degranulation
		SERPINA1	Unknown	17659342	CTD	Complement and coagulation cascades Platelet degranulation COPII-mediated vesicle transport +4 more
		SIRT1	Unknown	17581637 17652729	CTD	Nicotinate and nicotinamide metabolism Metabolic pathways FoxO signaling pathway +13 more
		SNCA	Unknown	17296847 18514411 26075822	CTD	Alzheimer disease Parkinson disease Pathways of neurodegeneration - multiple diseases +1 more
		SOD2	Unknown	10942521 12709579 15964507	CTD	FoxO signaling pathway Peroxisome Longevity regulating pathway +9 more
		SPTAN1	Unknown	25015659	CTD	Apoptosis Cytoskeleton in muscle cells Caspase-mediated cleavage of cytoskeletal proteins +5 more
		TARDBP	Unknown	33479441	CTD	mRNA surveillance pathway Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases
		TBCD	Unknown	27666370	CTD	—
		TTC19	Unknown	21278747	CTD	—
		VIM	Unknown	16831193	CTD	Cytoskeleton in muscle cells Epstein-Barr virus infection MicroRNAs in cancer +4 more
Neurodegenerative disorders	C0524851	AGPAT3	Unknown	—	Disgenet	Glycerolipid metabolism Glycerophospholipid metabolism Metabolic pathways +3 more
		APOD	Unknown	—	Disgenet	Transport of fatty acids NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
		APP	Unknown	—	Disgenet	Serotonergic synapse Alzheimer disease Pathways of neurodegeneration - multiple diseases +16 more
		ATXN1	Unknown	—	Disgenet	Notch signaling pathway Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases
		CRYAB	Unknown	—	Disgenet	Protein processing in endoplasmic reticulum Longevity regulating pathway - multiple species HSF1-dependent transactivation
		EPO	Unknown	—	Disgenet	Cytokine-cytokine receptor interaction HIF-1 signaling pathway Hormone signaling +8 more
		FTH1	Unknown	—	Disgenet	Porphyrin metabolism Ferroptosis Necroptosis +4 more
		FTL	Unknown	—	Disgenet	Porphyrin metabolism Ferroptosis Necroptosis +4 more
		FUS	Unknown	—	Disgenet	mRNA surveillance pathway Spliceosome Amyotrophic lateral sclerosis +3 more
		GDNF	Unknown	—	Disgenet	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +2 more
		GPX3	Unknown	—	Disgenet	Glutathione metabolism Metabolic pathways Thyroid hormone synthesis +4 more
		GSR	Unknown	—	Disgenet	Glutathione metabolism Metabolic pathways Thyroid hormone synthesis +4 more
		GSTM1	Unknown	—	Disgenet	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +10 more
		GSTM2	Unknown	—	Disgenet	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +10 more
		GSTM4	Unknown	—	Disgenet	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +11 more
		GSTM5	Unknown	—	Disgenet	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +10 more
		GSTO1	Unknown	—	Disgenet	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +13 more
		HCRT	Unknown	—	Disgenet	Neuroactive ligand-receptor interaction Hormone signaling Orexin and neuropeptides FF and QRFP bind to their respective receptors +1 more
		HMOX1	Unknown	—	Disgenet	Porphyrin metabolism Metabolic pathways HIF-1 signaling pathway +11 more
		IDO1	Unknown	—	Disgenet	Tryptophan metabolism Metabolic pathways Biosynthesis of cofactors +2 more
		IL6	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance Antifolate resistance Cytokine-cytokine receptor interaction +59 more
		KYNU	Unknown	—	Disgenet	Tryptophan metabolism Metabolic pathways Biosynthesis of cofactors +1 more
		MAPT	Unknown	—	Disgenet	MAPK signaling pathway Alzheimer disease Parkinson disease +2 more
		MGST1	Unknown	—	Disgenet	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +12 more
		NGF	Unknown	—	Disgenet	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +18 more
		NGFR	Unknown	—	Disgenet	Virion - Ebolavirus, Lyssavirus and Morbillivirus MAPK signaling pathway Ras signaling pathway +14 more
		PANK2	Unknown	—	Disgenet	Pantothenate and CoA biosynthesis Metabolic pathways Biosynthesis of cofactors +1 more
		PDE8B	Unknown	—	Disgenet	Purine metabolism Metabolic pathways Cortisol synthesis and secretion +3 more
		PKD2	Unknown	—	Disgenet	VxPx cargo-targeting to cilium
		PSEN1	Unknown	—	Disgenet	Wnt signaling pathway Notch signaling pathway Neurotrophin signaling pathway +12 more
		SELENOP	Unknown	—	Disgenet	Platelet degranulation
		SERPINA1	Unknown	—	Disgenet	Complement and coagulation cascades Platelet degranulation COPII-mediated vesicle transport +4 more
		SIRT1	Unknown	—	Disgenet	Nicotinate and nicotinamide metabolism Metabolic pathways FoxO signaling pathway +13 more
		SNCA	Unknown	—	Disgenet	Alzheimer disease Parkinson disease Pathways of neurodegeneration - multiple diseases +1 more
		SOD2	Unknown	—	Disgenet	FoxO signaling pathway Peroxisome Longevity regulating pathway +9 more
		SPTAN1	Unknown	—	Disgenet	Apoptosis Cytoskeleton in muscle cells Caspase-mediated cleavage of cytoskeletal proteins +5 more
		TARDBP	Unknown	—	Disgenet	mRNA surveillance pathway Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases
		TBCD	Unknown	—	Disgenet	—
		TTC19	Unknown	—	Disgenet	—
		VIM	Unknown	—	Disgenet	Cytoskeleton in muscle cells Epstein-Barr virus infection MicroRNAs in cancer +4 more

Neurodegenerative disease

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