Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
neoplasm of mature B-cells	MONDO_0004949	RANBP2	Unknown	23297126	Open Targets	Nucleocytoplasmic transport Viral life cycle - HIV-1 Amyotrophic lateral sclerosis +32 more
		REL	Unknown	28481359	Open Targets	Ras signaling pathway Transcriptional misregulation in cancer Viral carcinogenesis +1 more
		RET	Unknown	30802265	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		RGS7	Unknown	24388756	Open Targets	G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
		RHOA	Unknown	30802265 27325104 28481359	Open Targets	Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway +64 more
		RICTOR	Unknown	30802265	Open Targets	mTOR signaling pathway PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling +3 more
		RMI2	Unknown	30802265 27325104 28481359 19734449	Open Targets	Fanconi anemia pathway HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) +7 more
		ROBO2	Unknown	27325104	Open Targets	Axon guidance Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO
		ROS1	Unknown	23297126 24388756 28481359	Open Targets	—
		SALL4	Unknown	27325104	Open Targets	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells Regulation of PTEN gene transcription
		SETBP1	Unknown	23297126	Open Targets	—
		SETD1B	Unknown	23297126	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		SETD2	Unknown	28481359	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		SF3B1	Unknown	30802265	Open Targets	Spliceosome B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway +1 more
		SGK1	Unknown	30802265 37333831 27325104	Open Targets	FoxO signaling pathway Efferocytosis mTOR signaling pathway +6 more
		SMARCA4	Unknown	30802265 28481359	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +6 more
		SMC1A	Unknown	23297126	Open Targets	Cell cycle Oocyte meiosis Separation of Sister Chromatids +5 more
		SOCS1	Unknown	30802265 27566247 27325104 28481359 19734449	Open Targets	Ubiquitin mediated proteolysis Osteoclast differentiation JAK-STAT signaling pathway +13 more
		SPECC1	Unknown	23297126	Open Targets	—
		SPEN	Unknown	28481359	Open Targets	Notch signaling pathway
		SRSF2	Unknown	28481359	Open Targets	Spliceosome Herpes simplex virus 1 infection Transport of Mature mRNA derived from an Intron-Containing Transcript +4 more
		STAT6	Unknown	30802265 24388756 21796119 27325104	Open Targets	Necroptosis JAK-STAT signaling pathway Th1 and Th2 cell differentiation +7 more
		STK11	Unknown	28481359	Open Targets	FoxO signaling pathway Hormone signaling Autophagy - animal +9 more
		SYK	Unknown	30802265 24388756 27325104	Open Targets	NF-kappa B signaling pathway Phospholipase D signaling pathway PI3K-Akt signaling pathway +30 more
		TBL1XR1	Unknown	22496164 23297126	Open Targets	Wnt signaling pathway RORA activates gene expression PPARA activates gene expression +11 more
		TCF3	Unknown	1967982 28481359	Open Targets	Signaling pathways regulating pluripotency of stem cells Human T-cell leukemia virus 1 infection Transcriptional misregulation in cancer +2 more
		TET1	Unknown	23297126 28481359	Open Targets	—
		TET2	Unknown	30802265 21723201 28481359 29386642	Open Targets	—
		TMEM127	Unknown	28481359	Open Targets	—
		TNC	Unknown	27325104	Open Targets	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +6 more
		TNFAIP3	Unknown	27325104 19412163 30802265 27566247 24388756 23297126 28481359 24159176	Open Targets	NF-kappa B signaling pathway Necroptosis NOD-like receptor signaling pathway +10 more
		TNFRSF14	Unknown	20884631 27325104 30802265 24388756 23445872 23297126 28481359	Open Targets	Virion - Herpesvirus Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor +3 more
		TOP1	Unknown	28481359	Open Targets	SUMOylation of DNA replication proteins
		TP53	Unknown	16647949 17699855 10760686 30802265 10956404 24388756 10846560 9354678 1375111 12217802 21796119 23297126 29386642 28481359	Open Targets	Endocrine resistance Platinum drug resistance MAPK signaling pathway +85 more
		TP63	Unknown	30802265 22496164	Open Targets	MicroRNAs in cancer Activation of PUMA and translocation to mitochondria TP53 Regulates Metabolic Genes +5 more
		TRIM33	Unknown	23297126	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity
		USP6	Unknown	23297126 27325104	Open Targets	—
		USP9X	Unknown	23297126	Open Targets	Downregulation of SMAD2/3:SMAD4 transcriptional activity Ub-specific processing proteases Synthesis of active ubiquitin: roles of E1 and E2 enzymes +2 more
		WT1	Unknown	30802265	Open Targets	Transcriptional misregulation in cancer
		ZMYM3	Unknown	24388756 23297126 27325104	Open Targets	—
		ZNF521	Unknown	24388756	Open Targets	—

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Neoplasm of mature b-cells

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