Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
neoplasm of mature B-cells	MONDO_0004949	CREBBP	Unknown	27325104 21390126 30802265 27566247 24388756 21796119 29386642 23297126 28481359	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +52 more
		CSMD3	Unknown	30802265 27325104	Open Targets	—
		CTNNA2	Unknown	23297126	Open Targets	Hippo signaling pathway Adherens junction Leukocyte transendothelial migration +6 more
		CTNND1	Unknown	27325104	Open Targets	Rap1 signaling pathway Adherens junction Leukocyte transendothelial migration +3 more
		CXCR4	Unknown	37333831 24388756 28481359	Open Targets	Viral life cycle - HIV-1 Virion - Human immunodeficiency virus Calcium signaling pathway +15 more
		DDX3X	Unknown	30802265	Open Targets	RIG-I-like receptor signaling pathway Hepatitis B Viral carcinogenesis +1 more
		DNMT3A	Unknown	29386642	Open Targets	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		EBF1	Unknown	30802265 24388756	Open Targets	—
		EGFR	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Virion - Hepatitis viruses +79 more
		EP300	Unknown	37333831 27325104 22585168 21390126 30802265 24388756 21796119 28481359	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +66 more
		EPHA7	Unknown	30802265 23297126	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		ERBB2	Unknown	30802265 23297126	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +48 more
		ERBB3	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +19 more
		ERBB4	Unknown	30802265	Open Targets	MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway +22 more
		ERCC4	Unknown	23297126	Open Targets	Nucleotide excision repair Fanconi anemia pathway HDR through Single Strand Annealing (SSA) +4 more
		ERCC5	Unknown	27325104	Open Targets	Nucleotide excision repair Formation of Incision Complex in GG-NER Dual Incision in GG-NER +1 more
		ETV1	Unknown	30802265 23297126	Open Targets	Transcriptional misregulation in cancer
		EZH2	Unknown	24052547 23361872 27325104 25807917 26647218 30802265 22323599 24388756 21233829 21796119 23445872 29386642 22194861 28481359 20081860	Open Targets	Lysine degradation Metabolic pathways Polycomb repressive complex +7 more
		EZR	Unknown	23297126	Open Targets	Tight junction Leukocyte transendothelial migration Regulation of actin cytoskeleton +6 more
		FADD	Unknown	23297126	Open Targets	Platinum drug resistance Apoptosis Apoptosis - multiple species +36 more
		FAM47C	Unknown	27325104	Open Targets	—
		FANCD2	Unknown	30802265 24388756	Open Targets	Fanconi anemia pathway Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
		FAS	Unknown	24388756 11245438 30802265 21796119	Open Targets	Platinum drug resistance MAPK signaling pathway Cytokine-cytokine receptor interaction +36 more
		FAT1	Unknown	27325104 28481359	Open Targets	—
		FAT3	Unknown	27325104	Open Targets	—
		FBXO11	Unknown	30802265	Open Targets	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
		FBXW7	Unknown	28481359	Open Targets	Ubiquitin mediated proteolysis Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling +3 more
		FGFR2	Unknown	30802265	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +26 more
		FGFR3	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +27 more
		FKBP9	Unknown	27325104	Open Targets	—
		FLT4	Unknown	28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +6 more
		FOXO1	Unknown	30802265 37333831 23297126 28481359 21796119	Open Targets	FoxO signaling pathway AMPK signaling pathway Longevity regulating pathway +23 more
		FOXP1	Unknown	30802265	Open Targets	MicroRNAs in cancer Transcriptional regulation of pluripotent stem cells
		FUBP1	Unknown	28481359	Open Targets	—
		GLI1	Unknown	28481359	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Pathways in cancer +5 more
		GMPS	Unknown	23297126	Open Targets	Purine metabolism Drug metabolism - other enzymes Metabolic pathways +2 more
		GNAS	Unknown	23297126	Open Targets	Endocrine resistance Rap1 signaling pathway Calcium signaling pathway +58 more
		GPHN	Unknown	23297126	Open Targets	Folate biosynthesis Metabolic pathways Biosynthesis of cofactors +2 more
		GSK3B	Unknown	23297126	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Chemokine signaling pathway +59 more
		H3C2	Unknown	28481359	Open Targets	Neutrophil extracellular trap formation Alcoholism Shigellosis +27 more
		HSP90AA1	Unknown	27325104	Open Targets	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +56 more
		ID3	Unknown	24388756 28481359	Open Targets	TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells NGF-stimulated transcription
		IDH2	Unknown	29386642	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more
		IKZF3	Unknown	30802265 27338637	Open Targets	—
		KDM6A	Unknown	23297126	Open Targets	Transcriptional misregulation in cancer HDMs demethylate histones
		KIT	Unknown	30802265	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +15 more
		KMT2A	Unknown	28481359	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KMT2C	Unknown	30802265 23297126 27325104	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	37333831 30802265 27566247 24388756 31776129 21796119 23297126 28481359	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KNL1	Unknown	23297126	Open Targets	Cell cycle Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids +5 more

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Neoplasm of mature b-cells

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