Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	NR1H3	Causal	—	Disgenet	PPAR signaling pathway Efferocytosis Insulin resistance +12 more
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	TNFRSF1A	Causal	19525953 24076602 21833088 27386562 31604244 40262193	CTD, Disgenet, GWAS catalog	MAPK signaling pathway Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor +39 more
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	A2M	Unknown	—	Disgenet	Complement and coagulation cascades Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation +3 more
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	ABT1	Unknown	37377963	GWAS catalog	—
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	ACSF3	Unknown	31604244	GWAS catalog	Fatty acid biosynthesis Valine, leucine and isoleucine degradation Metabolic pathways +2 more
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	ADAMTSL1	Unknown	19010793	GWAS catalog	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	ADCY3	Unknown	31604244	GWAS catalog	Purine metabolism Metabolic pathways Endocrine resistance +61 more
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	AFF1	Unknown	31604244	GWAS catalog	Transcriptional misregulation in cancer
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	AGAP2	Unknown	21833088	GWAS catalog	FoxO signaling pathway Endocytosis
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	AGBL2	Unknown	24076602	GWAS catalog	—
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	AGER	Unknown	—	Disgenet	Efferocytosis Neutrophil extracellular trap formation AGE-RAGE signaling pathway in diabetic complications +7 more
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	AGPAT1	Unknown	37377963	GWAS catalog	Glycerolipid metabolism Glycerophospholipid metabolism Metabolic pathways +4 more
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	AHI1	Unknown	21833088 24076602 40262193	GWAS catalog	Anchoring of the basal body to the plasma membrane
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	AIM2	Unknown	31068361	CTD, Disgenet	NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway The AIM2 inflammasome
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	AKAP13	Unknown	31604244	GWAS catalog	Parathyroid hormone synthesis, secretion and action Human cytomegalovirus infection NRAGE signals death through JNK +2 more
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	ALDH1L1	Unknown	31604244	GWAS catalog	One carbon pool by folate Metabolic pathways Metabolism of folate and pterines
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	ALPK2	Unknown	21833088 26920376 31604244	GWAS catalog	—
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	ANKFN1	Unknown	39024449	GWAS catalog	—
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	ANKRD55	Unknown	24076602 27386562 31604244 37377963 40262193	GWAS catalog	—
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	APOA4	Unknown	31604244	GWAS catalog	Fat digestion and absorption Vitamin digestion and absorption Cholesterol metabolism +1 more
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	APOC2	Unknown	—	Disgenet	Cholesterol metabolism Chylomicron assembly Chylomicron remodeling +3 more
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	APOE	Unknown	15048896	CTD, Disgenet	Cholesterol metabolism Alzheimer disease Nuclear signaling by ERBB4 +10 more
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	ARHGAP26	Unknown	31604244	GWAS catalog	Rho GTPase cycle
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	ARHGAP27	Unknown	31604244	GWAS catalog	Rho GTPase cycle
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	ARHGEF10	Unknown	23412934	GWAS catalog	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	ARHGEF3	Unknown	26920376 31604244	GWAS catalog	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	ARL11	Unknown	23412934	GWAS catalog	—
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	ASAP1	Unknown	19525955	GWAS catalog	Endocytosis Fc gamma R-mediated phagocytosis VxPx cargo-targeting to cilium
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	ASAP2	Unknown	19010793	GWAS catalog	Endocytosis Fc gamma R-mediated phagocytosis
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	ATF1	Unknown	31604244	GWAS catalog	Aldosterone synthesis and secretion Transcriptional misregulation in cancer CREB phosphorylation +1 more
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	ATF6B	Unknown	37377963	GWAS catalog	cGMP-PKG signaling pathway Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway +22 more
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	ATP6	Unknown	—	Disgenet	Oxidative phosphorylation Metabolic pathways Thermogenesis +10 more
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	ATP8	Unknown	—	Disgenet	Oxidative phosphorylation Metabolic pathways Thermogenesis +10 more
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	ATXN1	Unknown	31604244	GWAS catalog	Notch signaling pathway Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	ATXN2	Unknown	31604244	GWAS catalog	Amyotrophic lateral sclerosis Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	AXDND1	Unknown	19010793	GWAS catalog	—
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	BACH2	Unknown	21833088 24076602 31604244 40262193	GWAS catalog	—
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	BAK1	Unknown	26920376	GWAS catalog	Platinum drug resistance Protein processing in endoplasmic reticulum Apoptosis +32 more
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	BATF	Unknown	21833088 24076602 31407831 31604244 40262193	GWAS catalog	PD-L1 expression and PD-1 checkpoint pathway in cancer Interleukin-4 and Interleukin-13 signaling
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	BATF3	Unknown	31604244	GWAS catalog	PD-L1 expression and PD-1 checkpoint pathway in cancer
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	BBX	Unknown	33296963	GWAS catalog	—
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	BCAS1	Unknown	31604244	GWAS catalog	—
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	BCHE	Unknown	20122907	CTD, Disgenet	Neurotransmitter clearance Synthesis of PC Synthesis, secretion, and deacylation of Ghrelin
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	BCL2	Unknown	31604244	GWAS catalog	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +46 more
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	BCL2L14	Unknown	31604244	GWAS catalog	TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	BICD1	Unknown	19010793	GWAS catalog	Viral life cycle - HIV-1 COPI-independent Golgi-to-ER retrograde traffic
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	BMAL1	Unknown	33296963	GWAS catalog	—
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	BOD1L2	Unknown	19010793	GWAS catalog	—
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	BORCS8-MEF2B	Unknown	31604244	GWAS catalog	cGMP-PKG signaling pathway Apelin signaling pathway Myogenesis
MULTIPLE SCLEROSIS	C0026769 MESH:D009103 MONDO_0005301	HLA-DRB1	Unknown	19525955 20598377 23472185 25911099	CTD, Disgenet, GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
MULTIPLE SCLEROSIS, RELAPSING-REMITTING	C0751967 MESH:D020529	APOE	Unknown	15096402 34624384	CTD, Disgenet	Cholesterol metabolism Alzheimer disease Nuclear signaling by ERBB4 +10 more
MULTIPLE SCLEROSIS, SUSCEPTIBILITY TO	MONDO:0007462PS126200	HLA-DRB1	Causal	14657362 11101853	ClinVar	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
MULTIPLE SCLEROSIS, SUSCEPTIBILITY TO, 5	MONDO:0013893	TNFRSF1A	Unknown	—	ClinVar	MAPK signaling pathway Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor +39 more

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Multiple sclerosis

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