Kidney failure

Complement and coagulation cascades Platelet degranulation Common Pathway of Fibrin Clot Formation COPII-mediated vesicle transport Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Post-translational protein phosphorylation +4 more

PPAR signaling pathway Alcoholic liver disease Fat digestion and absorption Triglyceride catabolism Heme degradation PPARA activates gene expression Regulation of lipid metabolism by PPARalpha +4 more

PPAR signaling pathway Fat digestion and absorption Triglyceride catabolism

Fatty acid biosynthesis Metabolic pathways Fatty acid metabolism AMPK signaling pathway Insulin signaling pathway Alcoholic liver disease ChREBP activates metabolic gene expression Vitamin B5 (pantothenate) metabolism Activation of gene expression by SREBF (SREBP) Fatty acyl-CoA biosynthesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis +8 more

Complement and coagulation cascades Platelet activation Neutrophil extracellular trap formation Coronavirus disease - COVID-19 Platelet degranulation Common Pathway of Fibrin Clot Formation Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins MAP2K and MAPK activation Regulation of TLR by endogenous ligand Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants +14 more

Th1 and Th2 cell differentiation Th17 cell differentiation Parathyroid hormone synthesis, secretion and action Inflammatory bowel disease Ub-specific processing proteases Interleukin-4 and Interleukin-13 signaling RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Factors involved in megakaryocyte development and platelet production +6 more

Regulation of Glucokinase by Glucokinase Regulatory Protein Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)

Gap junction Arrhythmogenic right ventricular cardiomyopathy Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly Gap junction degradation Regulation of gap junction activity Formation of annular gap junctions +4 more

Pyruvate metabolism Metabolic pathways Pyruvate metabolism

Glutathione metabolism Metabolic pathways Thyroid hormone synthesis Amyotrophic lateral sclerosis Huntington disease Pathways of neurodegeneration - multiple diseases Synthesis of 12-eicosatetraenoic acid derivatives Synthesis of 15-eicosatetraenoic acid derivatives Detoxification of Reactive Oxygen Species Purine catabolism +7 more

Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Drug metabolism - other enzymes Metabolic pathways Platinum drug resistance Pathways in cancer Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Hepatocellular carcinoma Fluid shear stress and atherosclerosis Glutathione conjugation +10 more

Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Drug metabolism - other enzymes Metabolic pathways Platinum drug resistance Pathways in cancer Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Hepatocellular carcinoma Fluid shear stress and atherosclerosis Glutathione conjugation +10 more

Hormone signaling Digestion

Hormone signaling TGF-beta signaling pathway

Terpenoid backbone biosynthesis Metabolic pathways AMPK signaling pathway Bile secretion Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP) EGR2 and SOX10-mediated initiation of Schwann cell myelination +5 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor JAK-STAT signaling pathway Interleukin-20 family signaling +1 more

MAPK signaling pathway Cytokine-cytokine receptor interaction Necroptosis Cellular senescence Osteoclast differentiation Hematopoietic cell lineage Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Type I diabetes mellitus Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Pertussis Leishmaniasis Tuberculosis Measles Influenza A Inflammatory bowel disease Rheumatoid arthritis Graft-versus-host disease Fluid shear stress and atherosclerosis Senescence-Associated Secretory Phenotype (SASP) Interleukin-1 processing Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection +24 more

Antifolate resistance MAPK signaling pathway Cytokine-cytokine receptor interaction NF-kappa B signaling pathway Necroptosis Osteoclast differentiation Toll-like receptor signaling pathway NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway Hematopoietic cell lineage IL-17 signaling pathway Th17 cell differentiation TNF signaling pathway Inflammatory mediator regulation of TRP channels Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Type I diabetes mellitus Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Legionellosis Yersinia infection Leishmaniasis Chagas disease African trypanosomiasis Malaria Amoebiasis Tuberculosis Measles Human cytomegalovirus infection Influenza A Herpes simplex virus 1 infection Coronavirus disease - COVID-19 Inflammatory bowel disease Rheumatoid arthritis Graft-versus-host disease Lipid and atherosclerosis Fluid shear stress and atherosclerosis Interleukin-1 processing CLEC7A/inflammasome pathway Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection +47 more

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Cell adhesion molecules Regulation of actin cytoskeleton Cytoskeleton in muscle cells Human papillomavirus infection Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Molecules associated with elastic fibres Integrin cell surface interactions ECM proteoglycans +10 more

Virion - Herpesvirus Rap1 signaling pathway Hormone signaling Phagosome Efferocytosis PI3K-Akt signaling pathway Osteoclast differentiation Focal adhesion ECM-receptor interaction Platelet activation Neutrophil extracellular trap formation Hematopoietic cell lineage Regulation of actin cytoskeleton Cytoskeleton in muscle cells Thyroid hormone signaling pathway Human cytomegalovirus infection Human papillomavirus infection Herpes simplex virus 1 infection Proteoglycans in cancer MicroRNAs in cancer Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Fluid shear stress and atherosclerosis Platelet degranulation Elastic fibre formation PECAM1 interactions Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions ECM proteoglycans Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway Signal transduction by L1 MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants +39 more

Phagosome Complement and coagulation cascades Staphylococcus aureus infection Coronavirus disease - COVID-19 Lectin pathway of complement activation Initial triggering of complement +3 more

Insulin resistance Non-alcoholic fatty liver disease PKA-mediated phosphorylation of key metabolic factors ChREBP activates metabolic gene expression +1 more

PPAR signaling pathway IL-17 signaling pathway Relaxin signaling pathway Coronavirus disease - COVID-19 Pathways in cancer Bladder cancer Rheumatoid arthritis Lipid and atherosclerosis Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Basigin interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-4 and Interleukin-13 signaling +11 more

IL-17 signaling pathway TNF signaling pathway Coronavirus disease - COVID-19 Transcriptional misregulation in cancer Prostate cancer Rheumatoid arthritis Lipid and atherosclerosis Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures EGFR Transactivation by Gastrin Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling +11 more

Phagosome Scavenging by Class A Receptors

Mineral absorption Metallothioneins bind metals Interferon gamma signaling

Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction Regulation of actin cytoskeleton Motor proteins Cytoskeleton in muscle cells Pathogenic Escherichia coli infection Regulation of actin dynamics for phagocytic cup formation RHO GTPases activate PAKs CD163 mediating an anti-inflammatory response FCGR3A-mediated phagocytosis +8 more

Chemokine signaling pathway Phagosome Osteoclast differentiation Neutrophil extracellular trap formation Fc gamma R-mediated phagocytosis Leukocyte transendothelial migration Prion disease Leishmaniasis Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases +14 more

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway Cytokine-cytokine receptor interaction PI3K-Akt signaling pathway Apoptosis Neurotrophin signaling pathway Inflammatory mediator regulation of TRP channels NGF processing Frs2-mediated activation ARMS-mediated activation Retrograde neurotrophin signalling TRKA activation by NGF PI3K/AKT activation NFG and proNGF binds to p75NTR NADE modulates death signalling NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival Axonal growth stimulation +18 more

NF-kappa B signaling pathway Complement and coagulation cascades Transcriptional misregulation in cancer Proteoglycans in cancer MicroRNAs in cancer Prostate cancer Neutrophil degranulation Dissolution of Fibrin Clot +5 more

PPAR signaling pathway cAMP signaling pathway Adipocytokine signaling pathway Glucagon signaling pathway Insulin resistance Non-alcoholic fatty liver disease Alcoholic liver disease Hepatitis C Chemical carcinogenesis - receptor activation Diabetic cardiomyopathy RORA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock SUMOylation of intracellular receptors +16 more

Arachidonic acid metabolism Metabolic pathways Platelet activation Serotonergic synapse Regulation of lipolysis in adipocytes COX reactions Synthesis of Prostaglandins (PG) and Thromboxanes (TX) +4 more

Arachidonic acid metabolism Metabolic pathways NF-kappa B signaling pathway Efferocytosis VEGF signaling pathway C-type lectin receptor signaling pathway IL-17 signaling pathway TNF signaling pathway Retrograde endocannabinoid signaling Serotonergic synapse Ovarian steroidogenesis Oxytocin signaling pathway Regulation of lipolysis in adipocytes Alzheimer disease Pathways of neurodegeneration - multiple diseases Leishmaniasis Human cytomegalovirus infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Chemical carcinogenesis - DNA adducts MicroRNAs in cancer Small cell lung cancer Nicotinamide salvaging Synthesis of 15-eicosatetraenoic acid derivatives Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Biosynthesis of DHA-derived SPMs Biosynthesis of EPA-derived SPMs Biosynthesis of DPAn-3 SPMs Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives +29 more

Neuroactive ligand-receptor interaction Hormone signaling Parathyroid hormone synthesis, secretion and action Endocrine and other factor-regulated calcium reabsorption Rheumatoid arthritis Class B/2 (Secretin family receptors) G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production +5 more

Antifolate resistance MAPK signaling pathway Ras signaling pathway cAMP signaling pathway Chemokine signaling pathway NF-kappa B signaling pathway HIF-1 signaling pathway Sphingolipid signaling pathway Mitophagy - animal PI3K-Akt signaling pathway Apoptosis Longevity regulating pathway Cellular senescence Osteoclast differentiation Neutrophil extracellular trap formation Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway IL-17 signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway B cell receptor signaling pathway TNF signaling pathway Neurotrophin signaling pathway Prolactin signaling pathway Adipocytokine signaling pathway Relaxin signaling pathway Insulin resistance Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Alzheimer disease Pathways of neurodegeneration - multiple diseases Cocaine addiction Epithelial cell signaling in Helicobacter pylori infection Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Legionellosis Yersinia infection Leishmaniasis Chagas disease Toxoplasmosis Amoebiasis Tuberculosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Transcriptional misregulation in cancer Viral carcinogenesis Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Pancreatic cancer Prostate cancer Chronic myeloid leukemia Acute myeloid leukemia Small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Inflammatory bowel disease Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Regulated proteolysis of p75NTR Downstream TCR signaling NF-kB is activated and signals survival Senescence-Associated Secretory Phenotype (SASP) FCERI mediated NF-kB activation DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-1 processing SUMOylation of immune response proteins IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling CD209 (DC-SIGN) signaling CLEC7A/inflammasome pathway The NLRP3 inflammasome Transcriptional Regulation by VENTX Interleukin-1 signaling TRAF6 mediated NF-kB activation Purinergic signaling in leishmaniasis infection +95 more

Neutrophil degranulation

Virion - Hepatitis viruses Phagosome Ovarian steroidogenesis Aldosterone synthesis and secretion Cortisol synthesis and secretion Cushing syndrome Fat digestion and absorption Bile secretion Vitamin digestion and absorption Cholesterol metabolism Hepatitis C Scavenging by Class B Receptors HDL clearance +10 more

Platelet degranulation Neutrophil degranulation

HIF-1 signaling pathway p53 signaling pathway Cellular senescence Apelin signaling pathway Hippo signaling pathway Complement and coagulation cascades AGE-RAGE signaling pathway in diabetic complications Chagas disease Platelet degranulation BMAL1:CLOCK,NPAS2 activates circadian gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription ECM proteoglycans Dissolution of Fibrin Clot +10 more

Parathyroid hormone synthesis, secretion and action Mineral absorption Type II Na+/Pi cotransporters Defective SLC34A1 causes hypophosphatemic nephrolithiasis/osteoporosis 1 (NPHLOP1) Surfactant metabolism +2 more

Sodium/Proton exchangers

AMPK signaling pathway Insulin signaling pathway Insulin resistance Non-alcoholic fatty liver disease Alcoholic liver disease RORA activates gene expression Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Activation of gene expression by SREBF (SREBP) NR1H2 & NR1H3 regulate gene expression linked to lipogenesis +7 more

Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Activation of gene expression by SREBF (SREBP) EGR2 and SOX10-mediated initiation of Schwann cell myelination +1 more

Th1 and Th2 cell differentiation Th17 cell differentiation Inflammatory bowel disease

Toll-like receptor signaling pathway Salmonella infection Chagas disease African trypanosomiasis Malaria Tuberculosis Measles Herpes simplex virus 1 infection PD-L1 expression and PD-1 checkpoint pathway in cancer PI3K Cascade Trafficking and processing of endosomal TLR Toll Like Receptor 9 (TLR9) Cascade TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome +12 more

The fatty acid cycling model The proton buffering model

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Complement and coagulation cascades Platelet activation Neutrophil extracellular trap formation Human papillomavirus infection Coronavirus disease - COVID-19 Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Integrin cell surface interactions Integrin signaling GRB2:SOS provides linkage to MAPK signaling for Integrins p130Cas linkage to MAPK signaling for integrins GP1b-IX-V activation signalling MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Platelet Adhesion to exposed collagen Platelet Aggregation (Plug Formation) Signaling downstream of RAS mutants +20 more

Purine metabolism Caffeine metabolism Drug metabolism - other enzymes Metabolic pathways Nucleotide metabolism Peroxisome Purine catabolism Butyrophilin (BTN) family interactions +5 more