Kidney failure

Glycosphingolipid biosynthesis - lacto and neolacto series Glycosphingolipid biosynthesis - globo and isoglobo series Metabolic pathways

ABC transporters ABC-family proteins mediated transport

Antifolate resistance ABC transporters Bile secretion Folate transport and metabolism Heme biosynthesis Heme degradation Iron uptake and transport +4 more

Mitochondrial Fatty Acid Beta-Oxidation

Renin-angiotensin system Renin secretion Chagas disease Coronavirus disease - COVID-19 Hypertrophic cardiomyopathy Diabetic cardiomyopathy Metabolism of Angiotensinogen to Angiotensins +4 more

Efferocytosis Alzheimer disease Epithelial cell signaling in Helicobacter pylori infection Degradation of the extracellular matrix Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation NOTCH3 Activation and Transmission of Signal to the Nucleus Amyloid fiber formation +10 more

Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins

Glycerolipid metabolism Metabolic pathways Glycerophospholipid biosynthesis Signaling by BRAF and RAF fusions +1 more

Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Renin-angiotensin system Renin secretion Aldosterone synthesis and secretion Cortisol synthesis and secretion Insulin resistance AGE-RAGE signaling pathway in diabetic complications Cushing syndrome Pathways in cancer Hypertrophic cardiomyopathy Dilated cardiomyopathy Diabetic cardiomyopathy PPARA activates gene expression Metabolism of Angiotensinogen to Angiotensins Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events +18 more

Cholesterol metabolism Alzheimer disease Nuclear signaling by ERBB4 Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport +10 more

African trypanosomiasis Scavenging of heme from plasma Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation +1 more

Calcium signaling pathway Neuroactive ligand-receptor interaction Cholinergic synapse Taste transduction Regulation of actin cytoskeleton Insulin secretion Salivary secretion Gastric acid secretion Pancreatic secretion Alzheimer disease Pathways of neurodegeneration - multiple diseases Muscarinic acetylcholine receptors G alpha (q) signalling events +10 more

Neddylation

Arginine biosynthesis Alanine, aspartate and glutamate metabolism Nitrogen metabolism Metabolic pathways Carbon metabolism Biosynthesis of amino acids Urea cycle +4 more

Phagosome Osteoclast differentiation Neutrophil extracellular trap formation NOD-like receptor signaling pathway Leukocyte transendothelial migration Prion disease Leishmaniasis Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation WNT5:FZD7-mediated leishmania damping +15 more

Steroid hormone biosynthesis Tryptophan metabolism Retinol metabolism Metabolism of xenobiotics by cytochrome P450 Metabolic pathways Ovarian steroidogenesis Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Lipid and atherosclerosis PPARA activates gene expression Xenobiotics Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of protectins +12 more

Steroid hormone biosynthesis Caffeine metabolism Tryptophan metabolism Linoleic acid metabolism Retinol metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 Metabolic pathways Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Methylation Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Aflatoxin activation and detoxification Biosynthesis of protectins Biosynthesis of maresin-like SPMs +15 more

Steroid biosynthesis Metabolic pathways Parathyroid hormone synthesis, secretion and action MicroRNAs in cancer Vitamin D (calciferol) metabolism Vitamins Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) +4 more

Wnt signaling pathway Cytoskeleton in muscle cells

Calcium signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Gap junction Dopaminergic synapse Parkinson disease Cocaine addiction Amphetamine addiction Morphine addiction Alcoholism Dopamine receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production +11 more

Motor proteins Vasopressin-regulated water reabsorption Salmonella infection Intraflagellar transport +1 more

cAMP signaling pathway HIF-1 signaling pathway Neuroactive ligand-receptor interaction Vascular smooth muscle contraction TNF signaling pathway Melanogenesis Renin secretion Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Pathways in cancer Hypertrophic cardiomyopathy Fluid shear stress and atherosclerosis Peptide ligand-binding receptors G alpha (q) signalling events +11 more

Cytokine-cytokine receptor interaction HIF-1 signaling pathway Hormone signaling Efferocytosis PI3K-Akt signaling pathway JAK-STAT signaling pathway Hematopoietic cell lineage Pathways in cancer Regulation of gene expression by Hypoxia-inducible Factor Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates RAS +8 more

Platinum drug resistance Nucleotide excision repair Fanconi anemia pathway HDR through Single Strand Annealing (SSA) Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Fanconi Anemia Pathway +5 more

Ras signaling pathway Cellular senescence Human T-cell leukemia virus 1 infection Pathways in cancer Renal cell carcinoma Oncogene Induced Senescence +3 more

FBXL7 down-regulates AURKA during mitotic entry and in early mitosis Neddylation Antigen processing: Ubiquitination & Proteasome degradation

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Regulation of actin cytoskeleton Pathways in cancer Chemical carcinogenesis - receptor activation Melanoma Breast cancer Gastric cancer PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR3 mutant receptor activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease FGFRL1 modulation of FGFR1 signaling RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR3 point mutants in cancer +40 more

Reversal of alkylation damage by DNA dioxygenases

Glycine, serine and threonine metabolism Arginine and proline metabolism Metabolic pathways Creatine metabolism +1 more

African trypanosomiasis Malaria Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Scavenging of heme from plasma Neutrophil degranulation Factors involved in megakaryocyte development and platelet production +4 more

Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways Carbon metabolism 2-Oxocarboxylic acid metabolism Biosynthesis of amino acids Peroxisome Central carbon metabolism in cancer Transcriptional activation of mitochondrial biogenesis Citric acid cycle (TCA cycle) +7 more

Proteasome Cytokine-cytokine receptor interaction HIF-1 signaling pathway Necroptosis TGF-beta signaling pathway Osteoclast differentiation Antigen processing and presentation JAK-STAT signaling pathway Natural killer cell mediated cytotoxicity IL-17 signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway Type I diabetes mellitus Leishmaniasis Chagas disease African trypanosomiasis Malaria Toxoplasmosis Amoebiasis Tuberculosis Hepatitis C Influenza A Herpes simplex virus 1 infection Pathways in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Fluid shear stress and atherosclerosis Interferon gamma signaling Regulation of IFNG signaling RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation +33 more

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway HIF-1 signaling pathway FoxO signaling pathway Phospholipase D signaling pathway Hormone signaling Oocyte meiosis Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Regulation of actin cytoskeleton Insulin signaling pathway Insulin secretion Ovarian steroidogenesis Progesterone-mediated oocyte maturation Prolactin signaling pathway Regulation of lipolysis in adipocytes Type II diabetes mellitus Insulin resistance Non-alcoholic fatty liver disease Type I diabetes mellitus Maturity onset diabetes of the young Aldosterone-regulated sodium reabsorption Alzheimer disease Prostate cancer Diabetic cardiomyopathy Insulin processing Synthesis, secretion, and deacylation of Ghrelin COPI-mediated anterograde transport PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation Insulin receptor signalling cascade Signaling by Insulin receptor Insulin receptor recycling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Amyloid fiber formation +39 more

Motor proteins COPI-dependent Golgi-to-ER retrograde traffic Kinesins

Cytokine-cytokine receptor interaction Neuroactive ligand-receptor interaction Hormone signaling AMPK signaling pathway JAK-STAT signaling pathway Adipocytokine signaling pathway Non-alcoholic fatty liver disease +4 more

MAPK signaling pathway Oxidative Stress Induced Senescence MAPK6/MAPK4 signaling Regulation of TP53 Activity through Phosphorylation +1 more

Neuroactive ligand-receptor interaction Hormone signaling Peptide ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production +2 more

Renin-angiotensin system Hematopoietic cell lineage Protein digestion and absorption Alzheimer disease Metabolism of Angiotensinogen to Angiotensins Neutrophil degranulation +3 more

Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo

One carbon pool by folate Metabolic pathways Antifolate resistance Folate transport and metabolism Metabolism of folate and pterines +2 more

cAMP signaling pathway HIF-1 signaling pathway Neuroactive ligand-receptor interaction Vascular smooth muscle contraction TNF signaling pathway Melanogenesis Renin secretion Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Pathways in cancer Hypertrophic cardiomyopathy Fluid shear stress and atherosclerosis Peptide ligand-binding receptors G alpha (q) signalling events +11 more

Cytokine-cytokine receptor interaction HIF-1 signaling pathway Hormone signaling Efferocytosis PI3K-Akt signaling pathway JAK-STAT signaling pathway Hematopoietic cell lineage Pathways in cancer Regulation of gene expression by Hypoxia-inducible Factor Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates RAS +8 more

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway HIF-1 signaling pathway FoxO signaling pathway Phospholipase D signaling pathway Hormone signaling Oocyte meiosis Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Regulation of actin cytoskeleton Insulin signaling pathway Insulin secretion Ovarian steroidogenesis Progesterone-mediated oocyte maturation Prolactin signaling pathway Regulation of lipolysis in adipocytes Type II diabetes mellitus Insulin resistance Non-alcoholic fatty liver disease Type I diabetes mellitus Maturity onset diabetes of the young Aldosterone-regulated sodium reabsorption Alzheimer disease Prostate cancer Diabetic cardiomyopathy Insulin processing Synthesis, secretion, and deacylation of Ghrelin COPI-mediated anterograde transport PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation Insulin receptor signalling cascade Signaling by Insulin receptor Insulin receptor recycling FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Amyloid fiber formation +39 more

One carbon pool by folate Metabolic pathways Antifolate resistance Folate transport and metabolism Metabolism of folate and pterines +2 more

Renin-angiotensin system Renin secretion Chagas disease Coronavirus disease - COVID-19 Hypertrophic cardiomyopathy Diabetic cardiomyopathy Metabolism of Angiotensinogen to Angiotensins +4 more

Phagosome Osteoclast differentiation Neutrophil extracellular trap formation NOD-like receptor signaling pathway Leukocyte transendothelial migration Prion disease Leishmaniasis Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation WNT5:FZD7-mediated leishmania damping +15 more

Steroid hormone biosynthesis Tryptophan metabolism Retinol metabolism Metabolism of xenobiotics by cytochrome P450 Metabolic pathways Ovarian steroidogenesis Chemical carcinogenesis - DNA adducts Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Lipid and atherosclerosis PPARA activates gene expression Xenobiotics Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) Biosynthesis of protectins +12 more

Cytokine-cytokine receptor interaction HIF-1 signaling pathway Hormone signaling Efferocytosis PI3K-Akt signaling pathway JAK-STAT signaling pathway Hematopoietic cell lineage Pathways in cancer Regulation of gene expression by Hypoxia-inducible Factor Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates RAS +8 more

One carbon pool by folate Metabolic pathways Antifolate resistance Folate transport and metabolism Metabolism of folate and pterines +2 more