Kidney disease

Glycosphingolipid biosynthesis - lacto and neolacto series Glycosphingolipid biosynthesis - globo and isoglobo series Metabolic pathways

ABC transporters Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) ABC-family proteins mediated transport +1 more

Antifolate resistance ABC transporters Bile secretion Folate transport and metabolism Heme biosynthesis Heme degradation Iron uptake and transport +4 more

Mitochondrial Fatty Acid Beta-Oxidation

Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins

Purine metabolism Metabolic pathways Endocrine resistance Rap1 signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway Phospholipase D signaling pathway Hormone signaling Oocyte meiosis Longevity regulating pathway Longevity regulating pathway - multiple species Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Apelin signaling pathway Gap junction Platelet activation Circadian entrainment Thermogenesis Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Inflammatory mediator regulation of TRP channels Insulin secretion GnRH signaling pathway Ovarian steroidogenesis Progesterone-mediated oocyte maturation Estrogen signaling pathway Melanogenesis Thyroid hormone synthesis Oxytocin signaling pathway Regulation of lipolysis in adipocytes Renin secretion Aldosterone synthesis and secretion Relaxin signaling pathway Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action Cushing syndrome Growth hormone synthesis, secretion and action Salivary secretion Gastric acid secretion Pancreatic secretion Bile secretion Parkinson disease Cocaine addiction Amphetamine addiction Morphine addiction Alcoholism Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Pathways in cancer Chemical carcinogenesis - receptor activation Dilated cardiomyopathy Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis +66 more

Purine metabolism Metabolic pathways Endocrine resistance Rap1 signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway Phospholipase D signaling pathway Hormone signaling Oocyte meiosis Longevity regulating pathway Longevity regulating pathway - multiple species Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Apelin signaling pathway Gap junction Platelet activation Circadian entrainment Thermogenesis Long-term potentiation Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse GABAergic synapse Taste transduction Inflammatory mediator regulation of TRP channels Insulin secretion GnRH signaling pathway Ovarian steroidogenesis Progesterone-mediated oocyte maturation Estrogen signaling pathway Melanogenesis Thyroid hormone synthesis Oxytocin signaling pathway Regulation of lipolysis in adipocytes Aldosterone synthesis and secretion Relaxin signaling pathway Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action Cushing syndrome Growth hormone synthesis, secretion and action Salivary secretion Gastric acid secretion Pancreatic secretion Bile secretion Morphine addiction Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Pathways in cancer Chemical carcinogenesis - receptor activation Dilated cardiomyopathy Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion G alpha (s) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis +61 more

Glycerolipid metabolism Metabolic pathways Glycerophospholipid biosynthesis Signaling by BRAF and RAF fusions +1 more

Starch and sucrose metabolism Metabolic pathways Neutrophil degranulation Glycogen breakdown (glycogenolysis) +1 more

African trypanosomiasis Scavenging of heme from plasma Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation +1 more

Arginine biosynthesis Arginine and proline metabolism Metabolic pathways Biosynthesis of amino acids Efferocytosis Amoebiasis Neutrophil degranulation Urea cycle +5 more

NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events

Amyotrophic lateral sclerosis Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases

Stimuli-sensing channels

MAPK signaling pathway Calcium signaling pathway Synaptic vesicle cycle Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Long-term depression Taste transduction Type II diabetes mellitus Spinocerebellar ataxia Morphine addiction Nicotine addiction Chemical carcinogenesis - receptor activation Presynaptic depolarization and calcium channel opening Regulation of insulin secretion +15 more

Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Phosphatidylinositol signaling system Oocyte meiosis Cellular senescence Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Apelin signaling pathway C-type lectin receptor signaling pathway Circadian entrainment Long-term potentiation Neurotrophin signaling pathway Dopaminergic synapse Olfactory transduction Phototransduction Inflammatory mediator regulation of TRP channels Insulin signaling pathway GnRH signaling pathway Estrogen signaling pathway Melanogenesis Oxytocin signaling pathway Glucagon signaling pathway Renin secretion Aldosterone synthesis and secretion Salivary secretion Gastric acid secretion Alzheimer disease Parkinson disease Pathways of neurodegeneration - multiple diseases Amphetamine addiction Alcoholism Pertussis Tuberculosis Human cytomegalovirus infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection Pathways in cancer Glioma Lipid and atherosclerosis Fluid shear stress and atherosclerosis CaMK IV-mediated phosphorylation of CREB Calmodulin induced events Cam-PDE 1 activation Platelet degranulation Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation PKA activation Synthesis of IP3 and IP4 in the cytosol Calcineurin activates NFAT eNOS activation Inactivation, recovery and regulation of the phototransduction cascade Stimuli-sensing channels FCERI mediated Ca+2 mobilization Ca2+ pathway Reduction of cytosolic Ca++ levels Sodium/Calcium exchangers Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Smooth Muscle Contraction Activation of Ca-permeable Kainate Receptor Uptake and function of anthrax toxins VEGFR2 mediated vascular permeability Phase 0 - rapid depolarisation Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation RHO GTPases activate IQGAPs RHO GTPases activate PAKs RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Glycogen breakdown (glycogenolysis) Protein methylation Extra-nuclear estrogen signaling Ion transport by P-type ATPases Activation of RAC1 downstream of NMDARs Long-term potentiation Signaling downstream of RAS mutants FCGR3A-mediated IL10 synthesis +79 more

Hedgehog signaling pathway Myogenesis Ligand-receptor interactions Activation of SMO +1 more

Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation +4 more

Anchoring of the basal body to the plasma membrane

Sphingolipid metabolism Metabolic pathways Sphingolipid signaling pathway Sphingolipid de novo biosynthesis +1 more

Calcium signaling pathway Neuroactive ligand-receptor interaction Cholinergic synapse Taste transduction Regulation of actin cytoskeleton Insulin secretion Salivary secretion Gastric acid secretion Pancreatic secretion Alzheimer disease Pathways of neurodegeneration - multiple diseases Muscarinic acetylcholine receptors G alpha (q) signalling events +10 more

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Cytoskeleton in muscle cells Protein digestion and absorption Human papillomavirus infection Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization +11 more

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Cytoskeleton in muscle cells Protein digestion and absorption Human papillomavirus infection Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization +11 more

Protein digestion and absorption Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Collagen chain trimerization +3 more

Neddylation

Arginine biosynthesis Alanine, aspartate and glutamate metabolism Nitrogen metabolism Metabolic pathways Carbon metabolism Biosynthesis of amino acids Urea cycle +4 more

mRNA surveillance pathway Transport of Mature mRNA Derived from an Intronless Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Processing of Intronless Pre-mRNAs +3 more

Salivary secretion Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation Amyloid fiber formation +2 more

African trypanosomiasis Scavenging of heme from plasma Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation +1 more

Salivary secretion Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Neutrophil degranulation Post-translational protein phosphorylation Amyloid fiber formation +2 more