Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
HEART FAILURE	EFO_0003144 C0018801 MESH:D006333	TTC39A	Unknown	36376295 41184235	GWAS catalog	—
		TTN	Unknown	36376295	GWAS catalog	Cytoskeleton in muscle cells Hypertrophic cardiomyopathy Dilated cardiomyopathy +2 more
		TUBB	Unknown	—	Disgenet	Phagosome Gap junction Motor proteins +16 more
		TXNRD1	Unknown	36071497	CTD, Disgenet	Selenocompound metabolism Pathways in cancer Hepatocellular carcinoma +6 more
		UCN2	Unknown	16330704	CTD, Disgenet	Neuroactive ligand-receptor interaction Hormone signaling Class B/2 (Secretin family receptors)
		UCP1	Unknown	26670611	CTD, Disgenet	PPAR signaling pathway Apelin signaling pathway Thermogenesis +3 more
		USP3	Unknown	20445134	GWAS catalog	Ub-specific processing proteases
		USP36	Unknown	36376295 40195560	GWAS catalog	—
		USP38	Unknown	40195560	GWAS catalog	—
		VEGFA	Unknown	15732037 15880336	CTD, Disgenet	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more
		VPS37D	Unknown	27790247	GWAS catalog	Endocytosis Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins +2 more
		VTI1A	Unknown	40195560	GWAS catalog	SNARE interactions in vesicular transport Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
		VWA7	Unknown	40195560	GWAS catalog	—
		VWDE	Unknown	40195560	GWAS catalog	—
		VWF	Unknown	22352330	CTD, Disgenet	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +20 more
		WFS1	Unknown	40195560	GWAS catalog	Protein processing in endoplasmic reticulum XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) +1 more
		WNT2B	Unknown	40195560	GWAS catalog	mTOR signaling pathway Wnt signaling pathway Hippo signaling pathway +13 more
		XAF1	Unknown	36071497	CTD, Disgenet	Interferon alpha/beta signaling
		XDH	Unknown	19933411	CTD, Disgenet	Purine metabolism Caffeine metabolism Drug metabolism - other enzymes +5 more
		XPO7	Unknown	40195560	GWAS catalog	Nucleocytoplasmic transport
		YWHAE	Unknown	36376295	GWAS catalog	Cell cycle Oocyte meiosis PI3K-Akt signaling pathway +22 more
		YY1	Unknown	—	Disgenet	ATP-dependent chromatin remodeling Polycomb repressive complex UCH proteinases +3 more
		ZBTB4	Unknown	40195560	GWAS catalog	—
		ZBTB46	Unknown	40195560	GWAS catalog	—
		ZC3HC1	Unknown	40195560	GWAS catalog	—
		ZCCHC8	Unknown	27790247	GWAS catalog	—
		ZEB2	Unknown	37429843 40195560	GWAS catalog	MicroRNAs in cancer
		ZFHX3	Unknown	27790247 34594039 36376295 36777996 40195560 41184235	GWAS catalog	Signaling pathways regulating pluripotency of stem cells RUNX3 regulates CDKN1A transcription
		ZFPM2	Unknown	40195560	GWAS catalog	MicroRNAs in cancer Factors involved in megakaryocyte development and platelet production
		ZHX3	Unknown	27790247	GWAS catalog	—
		ZNF280A	Unknown	36376295 40195560 41184235	GWAS catalog	—
		ZNF318	Unknown	40195560	GWAS catalog	—
		ZNF385D	Unknown	40465716	GWAS catalog	—
		ZNF592	Unknown	36376295 40195560	GWAS catalog	—
		ZNF638	Unknown	36376295	GWAS catalog	—
		ZPR1	Unknown	27790247	GWAS catalog	—
HEART FAILURE, DIASTOLIC	C1135196 MESH:D054144	ADRA1D	Unknown	29556499	CTD, Disgenet	Calcium signaling pathway cGMP-PKG signaling pathway Neuroactive ligand-receptor interaction +7 more
		AKIP1	Unknown	29556499	CTD, Disgenet	—
		ALOX15	Unknown	29556499	CTD, Disgenet	Arachidonic acid metabolism Linoleic acid metabolism Metabolic pathways +14 more
		ANKRD23	Unknown	29556499	CTD, Disgenet	Cytoskeleton in muscle cells
		APLN	Unknown	29556499	CTD, Disgenet	Neuroactive ligand-receptor interaction Apelin signaling pathway Peptide ligand-binding receptors +1 more
		CDC25B	Unknown	29556499	CTD, Disgenet	MAPK signaling pathway Cell cycle Progesterone-mediated oocyte maturation +4 more
		COL4A1	Unknown	29556499	CTD, Disgenet	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +20 more
		COL6A1	Unknown	29556499	CTD, Disgenet	PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction +11 more
		COL8A1	Unknown	29556499	CTD, Disgenet	Protein digestion and absorption Collagen degradation Collagen biosynthesis and modifying enzymes +3 more
		CREG1	Unknown	29556499	CTD, Disgenet	Neutrophil degranulation
		CXCL3	Unknown	29556499	CTD	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway +13 more
		CYRIB	Unknown	29556499	CTD, Disgenet	Regulation of actin cytoskeleton Platelet degranulation
		ELK3	Unknown	29556499	CTD, Disgenet	—
		EPN3	Unknown	29556499	CTD, Disgenet	Endocytosis

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Heart failure

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