Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
HEART FAILURE	C0018801 EFO_0003144 MESH:D006333	NEXN	Causal	—	Disgenet	—
		ABCA12	Unknown	27790247	GWAS catalog	ABC transporters ABC transporters in lipid homeostasis Defective ABCA12 causes autosomal recessive congenital ichthyosis type 4B
		ABCA4	Unknown	40465716	GWAS catalog	ABC transporters Retinoid cycle disease events The canonical retinoid cycle in rods (twilight vision) +1 more
		ABCC10	Unknown	40195560	GWAS catalog	ABC transporters ABC-family proteins mediated transport
		ABCG2	Unknown	36071497	CTD, Disgenet	Antifolate resistance ABC transporters Bile secretion +4 more
		ABHD17C	Unknown	40195560	GWAS catalog	—
		ABHD5	Unknown	40195560	GWAS catalog	Regulation of lipolysis in adipocytes
		ABO	Unknown	31919418 34594039 36376295 36777996 37429843 40195560 41184235	GWAS catalog	Glycosphingolipid biosynthesis - lacto and neolacto series Glycosphingolipid biosynthesis - globo and isoglobo series Metabolic pathways +1 more
		ACACA	Unknown	26670611	CTD, Disgenet	Fatty acid biosynthesis Pyruvate metabolism Propanoate metabolism +12 more
		ACAD10	Unknown	37429843	GWAS catalog	Mitochondrial Fatty Acid Beta-Oxidation
		ACADS	Unknown	30827304	CTD, Disgenet	Fatty acid degradation Valine, leucine and isoleucine degradation beta-Alanine metabolism +7 more
		ACE	Unknown	18586661	CTD, Disgenet	Renin-angiotensin system Renin secretion Chagas disease +4 more
		ACE2	Unknown	25973029	CTD, Disgenet	Renin-angiotensin system Protein digestion and absorption Coronavirus disease - COVID-19 +1 more
		ACLY	Unknown	26670611	CTD, Disgenet	Citrate cycle (TCA cycle) Metabolic pathways ChREBP activates metabolic gene expression +2 more
		ACTN2	Unknown	36376295 40195560	GWAS catalog	Cytoskeleton in muscle cells Arrhythmogenic right ventricular cardiomyopathy Platelet degranulation +3 more
		ADAMTSL1	Unknown	20445134	GWAS catalog	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
		ADCY5	Unknown	40195560	GWAS catalog	Purine metabolism Metabolic pathways Endocrine resistance +66 more
		ADIPOQ	Unknown	19367012 26670611	CTD, Disgenet	PPAR signaling pathway Hormone signaling AMPK signaling pathway +7 more
		ADORA2B	Unknown	40195560	GWAS catalog	Rap1 signaling pathway Calcium signaling pathway Neuroactive ligand-receptor interaction +6 more
		ADRA2C	Unknown	12374873	CTD, Disgenet	cGMP-PKG signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +6 more
		ADRB1	Unknown	12374873 14502278 15816327 21516734 7586371	CTD, Disgenet	Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +12 more
		ADRB3	Unknown	15009959 17440824	CTD, Disgenet	Calcium signaling pathway cGMP-PKG signaling pathway Neuroactive ligand-receptor interaction +9 more
		AGBL2	Unknown	40195560	GWAS catalog	—
		AGO2	Unknown	36376295	GWAS catalog	Pre-NOTCH Transcription and Translation MicroRNA (miRNA) biogenesis Ca2+ pathway +11 more
		AGT	Unknown	12025466 1330361 20811386	CTD, Disgenet	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +18 more
		AGTR1	Unknown	17208988 18214293 18586661	CTD, Disgenet	Calcium signaling pathway cGMP-PKG signaling pathway Phospholipase D signaling pathway +18 more
		AGXT2	Unknown	—	Disgenet	Alanine, aspartate and glutamate metabolism Glycine, serine and threonine metabolism Cysteine and methionine metabolism +4 more
		AKAP6	Unknown	40195560	GWAS catalog	—
		AKR1A1	Unknown	36376295	GWAS catalog	Glycolysis / Gluconeogenesis Pentose and glucuronate interconversions Ascorbate and aldarate metabolism +7 more
		AKT1S1	Unknown	40195560	GWAS catalog	Autophagy - animal mTOR signaling pathway AMPK signaling pathway +9 more
		ALB	Unknown	11771600	CTD, Disgenet	Thyroid hormone synthesis Platelet degranulation Recycling of bile acids and salts +7 more
		ALDH1A2	Unknown	27790247	GWAS catalog	Retinol metabolism Metabolic pathways RA biosynthesis pathway
		ALDH2	Unknown	37429843	GWAS catalog	Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Fatty acid degradation +14 more
		AMPD1	Unknown	—	Disgenet	Purine metabolism Metabolic pathways Nucleotide metabolism +2 more
		ANAPC4	Unknown	40195560	GWAS catalog	Cell cycle Oocyte meiosis Ubiquitin mediated proteolysis +18 more
		ANKRD26	Unknown	27790247	GWAS catalog	—
		ANKRD31	Unknown	27790247	GWAS catalog	—
		AOPEP	Unknown	34594039 36777996 40195560 41184235	GWAS catalog	Metabolism of Angiotensinogen to Angiotensins
		APCS	Unknown	16129801	CTD, Disgenet	Amyloid fiber formation
		APOB	Unknown	27790247	GWAS catalog	Fat digestion and absorption Vitamin digestion and absorption Cholesterol metabolism +20 more
		APOC1	Unknown	26670611 27790247	CTD, Disgenet, GWAS catalog	Cholesterol metabolism VLDL assembly VLDL clearance +1 more
		APOE	Unknown	—	Disgenet	Cholesterol metabolism Alzheimer disease Nuclear signaling by ERBB4 +10 more
		ARG2	Unknown	36071497	CTD, Disgenet	Arginine biosynthesis Arginine and proline metabolism Metabolic pathways +4 more
		ARHGAP26	Unknown	40195560	GWAS catalog	Rho GTPase cycle
		ARID5B	Unknown	40195560	GWAS catalog	HDMs demethylate histones
		ARL17B	Unknown	40195560	GWAS catalog	—
		ARPP21	Unknown	40195560	GWAS catalog	—
		ASXL3	Unknown	36376295 40195560 41184235	GWAS catalog	Polycomb repressive complex
		ATF1	Unknown	40195560	GWAS catalog	Aldosterone synthesis and secretion Transcriptional misregulation in cancer CREB phosphorylation +1 more
		ATP1A3	Unknown	18418421	CTD, Disgenet	cGMP-PKG signaling pathway cAMP signaling pathway Cardiac muscle contraction +18 more
HEART FAILURE, DIASTOLIC	C1135196	ACE	Unknown	—	Disgenet	Renin-angiotensin system Renin secretion Chagas disease +4 more

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Heart failure

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