Hearing loss

Insulin processing VxPx cargo-targeting to cilium

Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Neddylation Antigen processing: Ubiquitination & Proteasome degradation

TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer

Reversal of alkylation damage by DNA dioxygenases

Glycine, serine and threonine metabolism Metabolic pathways Threonine catabolism

Arginine biosynthesis Alanine, aspartate and glutamate metabolism Cysteine and methionine metabolism Arginine and proline metabolism Tyrosine metabolism Phenylalanine metabolism Phenylalanine, tyrosine and tryptophan biosynthesis Metabolic pathways Carbon metabolism 2-Oxocarboxylic acid metabolism Biosynthesis of amino acids Gluconeogenesis Aspartate and asparagine metabolism +10 more

mTOR signaling pathway Signaling by SCF-KIT IRS activation Signal attenuation Insulin receptor signalling cascade RET signaling +3 more

Calcium signaling pathway Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Gap junction Long-term potentiation Retrograde endocannabinoid signaling Glutamatergic synapse Alzheimer disease Huntington disease Pathways of neurodegeneration - multiple diseases G alpha (q) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Neurexins and neuroligins +10 more

Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of Incision Complex in GG-NER Dual Incision in GG-NER RNA Polymerase II Pre-transcription Events Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER TP53 Regulates Transcription of DNA Repair Genes mRNA Capping RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase I Transcription Termination RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE +19 more

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling +28 more

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling +28 more

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling +28 more

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling +28 more

Alanine, aspartate and glutamate metabolism Cysteine and methionine metabolism Valine, leucine and isoleucine degradation Tyrosine metabolism Phenylalanine metabolism Tryptophan metabolism Phenylalanine, tyrosine and tryptophan biosynthesis Metabolic pathways Phenylalanine metabolism +6 more

Regulation of actin cytoskeleton RHO GTPases activate IQGAPs Neutrophil degranulation

Interferon alpha/beta signaling

PI3K-Akt signaling pathway Focal adhesion ECM-receptor interaction Hematopoietic cell lineage Regulation of actin cytoskeleton Cytoskeleton in muscle cells Human papillomavirus infection Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Integrin cell surface interactions Smooth Muscle Contraction +9 more

Rap1 signaling pathway Phagosome Cell adhesion molecules Complement and coagulation cascades Neutrophil extracellular trap formation Hematopoietic cell lineage Leukocyte transendothelial migration Regulation of actin cytoskeleton Pertussis Legionellosis Leishmaniasis Amoebiasis Staphylococcus aureus infection Tuberculosis Transcriptional misregulation in cancer Acute myeloid leukemia Toll Like Receptor 4 (TLR4) Cascade Cell surface interactions at the vascular wall Integrin cell surface interactions Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation +18 more

Regulation of TP53 Activity through Methylation

Protein processing in endoplasmic reticulum COPII-mediated vesicle transport Cargo concentration in the ER Transport to the Golgi and subsequent modification +1 more

Assembly of active LPL and LIPC lipase complexes

Adherens junction Neddylation Antigen processing: Ubiquitination & Proteasome degradation

Mitophagy - animal Autophagy - animal Ferroptosis Apelin signaling pathway NOD-like receptor signaling pathway Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Shigellosis Kaposi sarcoma-associated herpesvirus infection +6 more

IL-17 signaling pathway MAPK6/MAPK4 signaling

Efferocytosis

Ascorbate and aldarate metabolism Inositol phosphate metabolism Metabolic pathways Biosynthesis of nucleotide sugars Synthesis of IP2, IP, and Ins in the cytosol +2 more

Insulin resistance Non-alcoholic fatty liver disease PKA-mediated phosphorylation of key metabolic factors ChREBP activates metabolic gene expression +1 more

Endocrine resistance Leukocyte transendothelial migration GnRH signaling pathway Estrogen signaling pathway Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Pathways in cancer Proteoglycans in cancer Bladder cancer Diabetic cardiomyopathy Fluid shear stress and atherosclerosis Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling +15 more

Ribosome Mitochondrial translation elongation Mitochondrial translation termination

Motor proteins Pathogenic Escherichia coli infection Salmonella infection Gap junction degradation Trafficking of AMPA receptors +2 more

Retrograde endocannabinoid signaling Biosynthesis of A2E, implicated in retinal degradation

Olfactory transduction Activation of Ca-permeable Kainate Receptor

Condensation of Prophase Chromosomes

cAMP signaling pathway Chemokine signaling pathway NF-kappa B signaling pathway Apoptosis Osteoclast differentiation Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway IL-17 signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway B cell receptor signaling pathway TNF signaling pathway Neurotrophin signaling pathway Adipocytokine signaling pathway Relaxin signaling pathway Insulin resistance Alcoholic liver disease Epithelial cell signaling in Helicobacter pylori infection Pathogenic Escherichia coli infection Shigellosis Salmonella infection Legionellosis Yersinia infection Leishmaniasis Chagas disease Toxoplasmosis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Pathways in cancer Viral carcinogenesis Chemical carcinogenesis - reactive oxygen species Prostate cancer Chronic myeloid leukemia Small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Lipid and atherosclerosis Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex SUMOylation of immune response proteins IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling Ub-specific processing proteases Interleukin-1 signaling TRAF6 mediated NF-kB activation +58 more

Cytoskeleton in muscle cells Laminin interactions

AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Alzheimer disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Detoxification of Reactive Oxygen Species +3 more

Protein processing in endoplasmic reticulum Translesion Synthesis by POLH

Motor proteins Pathogenic Escherichia coli infection Salmonella infection Gap junction degradation Trafficking of AMPA receptors +2 more

Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Phagosome Cell adhesion molecules Antigen processing and presentation Hematopoietic cell lineage Th1 and Th2 cell differentiation Th17 cell differentiation Intestinal immune network for IgA production Type I diabetes mellitus Leishmaniasis Toxoplasmosis Staphylococcus aureus infection Tuberculosis Influenza A Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Asthma Autoimmune thyroid disease Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Viral myocarditis Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation PD-1 signaling Interferon gamma signaling +28 more

Interferon alpha/beta signaling

Motor proteins Pathogenic Escherichia coli infection Salmonella infection Gap junction degradation Trafficking of AMPA receptors +2 more

Cytoskeleton in muscle cells Laminin interactions