Gastroesophageal reflux disease

Alanine, aspartate and glutamate metabolism Valine, leucine and isoleucine degradation beta-Alanine metabolism Propanoate metabolism Butanoate metabolism Metabolic pathways GABAergic synapse Degradation of GABA +5 more

Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine signaling pathway NF-kappa B signaling pathway Phospholipase D signaling pathway Cellular senescence Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway IL-17 signaling pathway Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Epithelial cell signaling in Helicobacter pylori infection Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Legionellosis Yersinia infection Chagas disease Malaria Amoebiasis Hepatitis B Human cytomegalovirus infection Influenza A Kaposi sarcoma-associated herpesvirus infection Coronavirus disease - COVID-19 Pathways in cancer Transcriptional misregulation in cancer Bladder cancer Rheumatoid arthritis Lipid and atherosclerosis Senescence-Associated Secretory Phenotype (SASP) Peptide ligand-binding receptors Chemokine receptors bind chemokines ATF4 activates genes in response to endoplasmic reticulum stress G alpha (i) signalling events Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling +37 more

Arachidonic acid metabolism Metabolic pathways NF-kappa B signaling pathway Efferocytosis VEGF signaling pathway C-type lectin receptor signaling pathway IL-17 signaling pathway TNF signaling pathway Retrograde endocannabinoid signaling Serotonergic synapse Ovarian steroidogenesis Oxytocin signaling pathway Regulation of lipolysis in adipocytes Alzheimer disease Pathways of neurodegeneration - multiple diseases Leishmaniasis Human cytomegalovirus infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Chemical carcinogenesis - DNA adducts MicroRNAs in cancer Small cell lung cancer Nicotinamide salvaging Synthesis of 15-eicosatetraenoic acid derivatives Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Biosynthesis of DHA-derived SPMs Biosynthesis of EPA-derived SPMs Biosynthesis of DPAn-3 SPMs Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives +29 more

Neuroactive ligand-receptor interaction Tachykinin receptors bind tachykinins G alpha (q) signalling events

Alanine, aspartate and glutamate metabolism Valine, leucine and isoleucine degradation beta-Alanine metabolism Propanoate metabolism Butanoate metabolism Metabolic pathways GABAergic synapse Degradation of GABA +5 more

ABC transporters Fat digestion and absorption Bile secretion Cholesterol metabolism ABC transporters in lipid homeostasis Defective ABCG8 causes gallbladder disease 4 and sitosterolemia Defective ABCG5 causes sitosterolemia NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux +5 more

Regulation of lipolysis in adipocytes

Renin-angiotensin system Renin secretion Chagas disease Coronavirus disease - COVID-19 Hypertrophic cardiomyopathy Diabetic cardiomyopathy Metabolism of Angiotensinogen to Angiotensins +4 more

Invadopodia formation

Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins

Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins

C6 deamination of adenosine Formation of editosomes by ADAR proteins

Stimuli-sensing channels

Fat digestion and absorption Vitamin digestion and absorption Cholesterol metabolism Lipid and atherosclerosis Cell surface interactions at the vascular wall Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class H Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Platelet sensitization by LDL Regulation of TLR by endogenous ligand Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance LDL clearance LDL remodeling VLDL clearance Retinoid metabolism and transport +20 more

Cholesterol metabolism Chylomicron assembly Chylomicron remodeling HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport +3 more

VLDL assembly VLDL clearance NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux

Cholesterol metabolism Alzheimer disease Nuclear signaling by ERBB4 Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport +10 more

Serotonergic synapse Alzheimer disease Pathways of neurodegeneration - multiple diseases Platelet degranulation ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (q) signalling events G alpha (i) signalling events Lysosome Vesicle Biogenesis Formyl peptide receptors bind formyl peptides and many other ligands TAK1 activates NFkB by phosphorylation and activation of IKKs complex The NLRP3 inflammasome Advanced glycosylation endproduct receptor signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Post-translational protein phosphorylation TRAF6 mediated NF-kB activation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Purinergic signaling in leishmaniasis infection Amyloid fiber formation +16 more

Rho GTPase cycle

Neddylation Antigen processing: Ubiquitination & Proteasome degradation

Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Efferocytosis Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Osteoclast differentiation Thyroid hormone signaling pathway Pancreatic secretion Alzheimer disease Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Diabetic cardiomyopathy Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases +16 more

Amyotrophic lateral sclerosis Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases

Glycosphingolipid biosynthesis - lacto and neolacto series Metabolic pathways Asparagine N-linked glycosylation Lewis blood group biosynthesis +1 more

C-type lectin receptor signaling pathway TNF signaling pathway

Golgi Associated Vesicle Biogenesis

Butyrophilin (BTN) family interactions

Butyrophilin (BTN) family interactions

Butyrophilin (BTN) family interactions

Butyrophilin (BTN) family interactions

Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry

MAPK signaling pathway Calcium signaling pathway Synaptic vesicle cycle Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Long-term depression Taste transduction Type II diabetes mellitus Spinocerebellar ataxia Morphine addiction Nicotine addiction Chemical carcinogenesis - receptor activation Presynaptic depolarization and calcium channel opening Regulation of insulin secretion +15 more

MAPK signaling pathway Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Cellular senescence Cardiac muscle contraction Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Tight junction Circadian entrainment Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Insulin secretion GnRH signaling pathway Oxytocin signaling pathway Renin secretion Aldosterone synthesis and secretion Cortisol synthesis and secretion GnRH secretion Type II diabetes mellitus Cushing syndrome Growth hormone synthesis, secretion and action Carbohydrate digestion and absorption Alzheimer disease Prion disease Pathways of neurodegeneration - multiple diseases Amphetamine addiction Chemical carcinogenesis - receptor activation Hypertrophic cardiomyopathy Arrhythmogenic right ventricular cardiomyopathy Dilated cardiomyopathy Regulation of insulin secretion Phase 0 - rapid depolarisation Phase 2 - plateau phase +35 more

Endocytosis Motor proteins Cytoskeleton in muscle cells MHC class II antigen presentation HSP90 chaperone cycle for steroid hormone receptors (SHR) COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic +4 more

Factors involved in megakaryocyte development and platelet production

Calcium signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Gastric acid secretion Peptide ligand-binding receptors G alpha (q) signalling events Gastrin-CREB signalling pathway via PKC and MAPK +4 more

Arachidonic acid metabolism Metabolic pathways NF-kappa B signaling pathway Efferocytosis VEGF signaling pathway C-type lectin receptor signaling pathway IL-17 signaling pathway TNF signaling pathway Retrograde endocannabinoid signaling Serotonergic synapse Ovarian steroidogenesis Oxytocin signaling pathway Regulation of lipolysis in adipocytes Alzheimer disease Pathways of neurodegeneration - multiple diseases Leishmaniasis Human cytomegalovirus infection Human papillomavirus infection Kaposi sarcoma-associated herpesvirus infection Pathways in cancer Chemical carcinogenesis - DNA adducts MicroRNAs in cancer Small cell lung cancer Nicotinamide salvaging Synthesis of 15-eicosatetraenoic acid derivatives Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Biosynthesis of DHA-derived SPMs Biosynthesis of EPA-derived SPMs Biosynthesis of DPAn-3 SPMs Biosynthesis of electrophilic ω-3 PUFA oxo-derivatives +29 more

Neuroactive ligand-receptor interaction Tachykinin receptors bind tachykinins G alpha (q) signalling events