Subtype of: Gastric cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
gastric intestinal type adenocarcinoma	MONDO_0005037	RICTOR	Unknown	24816253 29945994 25042771	Open Targets	mTOR signaling pathway PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling +3 more
		RMI2	Unknown	29945994 33328548	Open Targets	Fanconi anemia pathway HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) +7 more
		RNF213	Unknown	24816253 29945994 33328548 25042771	Open Targets	Suppression of apoptosis Antigen processing: Ubiquitination & Proteasome degradation
		RNF43	Unknown	24816253 29945994 25042771 22484628	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation
		ROBO2	Unknown	24816253 22484628 25042771	Open Targets	Axon guidance Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO
		ROCK1	Unknown	24816253 29945994 24807215	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway +25 more
		ROS1	Unknown	24816253 22484628 24807215 36232418 33328548 25042771	Open Targets	—
		RPL22	Unknown	24816253 29945994 25042771	Open Targets	Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression +7 more
		RPL5	Unknown	24816253	Open Targets	Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression +7 more
		RPN1	Unknown	29945994	Open Targets	N-Glycan biosynthesis Various types of N-glycan biosynthesis Metabolic pathways +2 more
		RSPO2	Unknown	25042771	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination
		RSPO3	Unknown	25042771	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination RUNX1 regulates transcription of genes involved in WNT signaling
		RUNX1T1	Unknown	33328548 24816253 29945994 24807215 24690483	Open Targets	Pathways in cancer Transcriptional misregulation in cancer Acute myeloid leukemia
		RXRA	Unknown	24816253	Open Targets	PPAR signaling pathway Efferocytosis PI3K-Akt signaling pathway +39 more
		SALL4	Unknown	29945994 25042771	Open Targets	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells Regulation of PTEN gene transcription
		SBDS	Unknown	24807215	Open Targets	Ribosome biogenesis in eukaryotes
		SDHA	Unknown	24816253 25042771	Open Targets	Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways +12 more
		SDHAF2	Unknown	36232418	Open Targets	—
		SDHB	Unknown	24816253	Open Targets	Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways +12 more
		SDHC	Unknown	24816253 29945994	Open Targets	Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways +12 more
		SEPTIN5	Unknown	24816253 29945994 25042771	Open Targets	Parkinson disease Pathways of neurodegeneration - multiple diseases
		SEPTIN9	Unknown	24816253 33328548 25042771	Open Targets	Bacterial invasion of epithelial cells Shigellosis
		SETBP1	Unknown	24816253 29945994 25042771	Open Targets	—
		SETD1B	Unknown	24816253 29945994 25042771	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		SETD2	Unknown	24816253 24807215 36232418 33328548 25042771 29945994	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		SETDB1	Unknown	24816253 29945994	Open Targets	Lysine degradation Metabolic pathways Signaling pathways regulating pluripotency of stem cells +1 more
		SF3B1	Unknown	33328548	Open Targets	Spliceosome B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway +1 more
		SFRP4	Unknown	24816253 29945994 36232418	Open Targets	Wnt signaling pathway
		SGK1	Unknown	25042771	Open Targets	FoxO signaling pathway Efferocytosis mTOR signaling pathway +6 more
		SH2B3	Unknown	29945994	Open Targets	Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
		SHTN1	Unknown	29945994	Open Targets	—
		SIX2	Unknown	29945994	Open Targets	—
		SKI	Unknown	29945994 25042771	Open Targets	TGF-beta signaling pathway Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity
		SLC34A2	Unknown	25042771	Open Targets	Parathyroid hormone synthesis, secretion and action Mineral absorption Type II Na+/Pi cotransporters +2 more
		SMAD2	Unknown	33328548	Open Targets	Cell cycle Endocytosis Cellular senescence +30 more
		SMAD3	Unknown	24816253 25042771	Open Targets	FoxO signaling pathway Cell cycle Endocytosis +34 more
		SMAD4	Unknown	9331080 24816253 22484628 25656989 36232418 25042771 29945994	Open Targets	FoxO signaling pathway Hormone signaling Cell cycle +30 more
		SMARCA4	Unknown	24816253 38584451 30474112 36232418 33328548 29945994	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +6 more
		SMARCB1	Unknown	29945994 25656989 33328548	Open Targets	ATP-dependent chromatin remodeling Viral life cycle - HIV-1 Thermogenesis +3 more
		SMARCE1	Unknown	29945994	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		SMC1A	Unknown	25042771	Open Targets	Cell cycle Oocyte meiosis Separation of Sister Chromatids +5 more
		SMO	Unknown	23349881 24816253 36232418 33328548	Open Targets	Hedgehog signaling pathway Axon guidance Pathways in cancer +6 more
		SND1	Unknown	29945994 25042771	Open Targets	Viral carcinogenesis Signaling by BRAF and RAF fusions
		SNX29	Unknown	25042771	Open Targets	—
		SOCS1	Unknown	33328548	Open Targets	Ubiquitin mediated proteolysis Osteoclast differentiation JAK-STAT signaling pathway +13 more
		SOS1	Unknown	24816253 29945994 25042771	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +97 more
		SOX2	Unknown	24816253 33328548	Open Targets	Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation +4 more
		SOX21	Unknown	29945994	Open Targets	—
		SPECC1	Unknown	24816253 24807215 25042771	Open Targets	—
		SPEN	Unknown	24816253 29945994 36232418 25042771	Open Targets	Notch signaling pathway

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Gastric intestinal type adenocarcinoma

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