Fatty liver

Bile secretion Nuclear Receptor transcription pathway

Circadian rhythm PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Nuclear Receptor transcription pathway Circadian Clock +2 more

PPAR signaling pathway Efferocytosis Insulin resistance Non-alcoholic fatty liver disease Hepatitis C PPARA activates gene expression Nuclear Receptor transcription pathway SUMOylation of intracellular receptors VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis +12 more

Bile secretion Recycling of bile acids and salts Synthesis of bile acids and bile salts Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol Synthesis of bile acids and bile salts via 27-hydroxycholesterol PPARA activates gene expression Endogenous sterols Nuclear Receptor transcription pathway SUMOylation of intracellular receptors +6 more

Nuclear Receptor transcription pathway SUMOylation of intracellular receptors

Terpenoid backbone biosynthesis Synthesis of Dolichyl-phosphate Defective DHDDS causes retinitis pigmentosa 59

PPAR signaling pathway PPARA activates gene expression

Glycerolipid metabolism Metabolic pathways Acyl chain remodeling of DAG and TAG

cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Estrogen signaling pathway Melanogenesis Adipocytokine signaling pathway Aldosterone synthesis and secretion Cortisol synthesis and secretion Cushing syndrome Opioid Signalling Androgen biosynthesis Glucocorticoid biosynthesis G-protein activation Peptide hormone biosynthesis Endogenous sterols Peptide ligand-binding receptors G alpha (s) signalling events G alpha (i) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Interleukin-4 and Interleukin-13 signaling ADORA2B mediated anti-inflammatory cytokines production +18 more

Synthesis of 5-eicosatetraenoic acids

PPAR signaling pathway cAMP signaling pathway Adipocytokine signaling pathway Glucagon signaling pathway Insulin resistance Non-alcoholic fatty liver disease Alcoholic liver disease Hepatitis C Chemical carcinogenesis - receptor activation Diabetic cardiomyopathy RORA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock SUMOylation of intracellular receptors +16 more

PPAR signaling pathway Efferocytosis Wnt signaling pathway Pathways in cancer Acute myeloid leukemia Carnitine metabolism Regulation of pyruvate dehydrogenase (PDH) complex Nuclear Receptor transcription pathway Signaling by Retinoic Acid +6 more

Chemokine signaling pathway Autophagy - animal Vascular smooth muscle contraction NOD-like receptor signaling pathway C-type lectin receptor signaling pathway Fc gamma R-mediated phagocytosis Neurotrophin signaling pathway Inflammatory mediator regulation of TRP channels GnRH signaling pathway Estrogen signaling pathway Type II diabetes mellitus Insulin resistance AGE-RAGE signaling pathway in diabetic complications Prion disease Shigellosis Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy Apoptotic cleavage of cellular proteins Calmodulin induced events Effects of PIP2 hydrolysis SHC1 events in ERBB2 signaling DAG and IP3 signaling Role of phospholipids in phagocytosis HuR (ELAVL1) binds and stabilizes mRNA VEGFR2 mediated cell proliferation CLEC7A (Dectin-1) signaling RHO GTPases Activate NADPH Oxidases Neutrophil degranulation Interferon gamma signaling +26 more

Proteasome Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Spinocerebellar ataxia Prion disease Pathways of neurodegeneration - multiple diseases Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants that don't undergo autocatalytic processing are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases Neutrophil degranulation CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Interleukin-1 signaling Antigen processing: Ubiquitination & Proteasome degradation +57 more

Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance FoxO signaling pathway Phosphatidylinositol signaling system Sphingolipid signaling pathway p53 signaling pathway Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway Cellular senescence Focal adhesion Insulin resistance Human papillomavirus infection Human T-cell leukemia virus 1 infection Pathways in cancer MicroRNAs in cancer Chemical carcinogenesis - reactive oxygen species Endometrial cancer Glioma Prostate cancer Melanoma Small cell lung cancer Breast cancer Hepatocellular carcinoma Central carbon metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Diabetic cardiomyopathy Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Negative regulation of the PI3K/AKT network Downstream TCR signaling TP53 Regulates Metabolic Genes PTEN Loss of Function in Cancer Ub-specific processing proteases Ovarian tumor domain proteases Regulation of PTEN mRNA translation Regulation of PTEN localization Regulation of PTEN stability and activity Transcriptional Regulation by MECP2 +37 more

Necroptosis NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway TNF signaling pathway Salmonella infection TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 TRIF-mediated programmed cell death TRP channels RIPK1-mediated regulated necrosis TLR3-mediated TICAM1-dependent programmed cell death IKK complex recruitment mediated by RIP1 +9 more

Biosynthesis of unsaturated fatty acids Metabolic pathways Fatty acid metabolism PPAR signaling pathway AMPK signaling pathway Alcoholic liver disease Activation of gene expression by SREBF (SREBP) Fatty acyl-CoA biosynthesis NR1H2 & NR1H3 regulate gene expression linked to lipogenesis +6 more

Glucocorticoid biosynthesis

HIF-1 signaling pathway p53 signaling pathway Cellular senescence Apelin signaling pathway Hippo signaling pathway Complement and coagulation cascades AGE-RAGE signaling pathway in diabetic complications Chagas disease Platelet degranulation BMAL1:CLOCK,NPAS2 activates circadian gene expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription ECM proteoglycans Dissolution of Fibrin Clot +10 more

Nicotinate and nicotinamide metabolism Metabolic pathways FoxO signaling pathway Efferocytosis AMPK signaling pathway Longevity regulating pathway Longevity regulating pathway - multiple species Cellular senescence Wnt signaling pathway Glucagon signaling pathway Alcoholic liver disease Amphetamine addiction MicroRNAs in cancer Regulation of HSF1-mediated heat shock response SIRT1 negatively regulates rRNA expression Regulation of FOXO transcriptional activity by acetylation +13 more

Nicotinate and nicotinamide metabolism Metabolic pathways Thermogenesis Central carbon metabolism in cancer Processing of DNA double-strand break ends +2 more

Nicotinate and nicotinamide metabolism Metabolic pathways

Sodium-coupled sulphate, di- and tri-carboxylate transporters

Bile secretion Folate transport and metabolism Organic anion transport

Insulin secretion Prolactin signaling pathway Glucagon signaling pathway Type II diabetes mellitus Insulin resistance Maturity onset diabetes of the young Carbohydrate digestion and absorption Central carbon metabolism in cancer Cellular hexose transport Regulation of insulin secretion Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS) Intestinal hexose absorption +9 more

Peroxisome Longevity regulating pathway - multiple species Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Platelet degranulation Detoxification of Reactive Oxygen Species Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation +8 more

FoxO signaling pathway Peroxisome Longevity regulating pathway Longevity regulating pathway - multiple species Huntington disease Chemical carcinogenesis - reactive oxygen species Lipid and atherosclerosis Transcriptional activation of mitochondrial biogenesis Detoxification of Reactive Oxygen Species Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes +9 more

AMPK signaling pathway Insulin signaling pathway Insulin resistance Non-alcoholic fatty liver disease Alcoholic liver disease RORA activates gene expression Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Activation of gene expression by SREBF (SREBP) NR1H2 & NR1H3 regulate gene expression linked to lipogenesis +7 more

Steroid hormone biosynthesis Metabolic pathways Glycosphingolipid metabolism The activation of arylsulfatases +1 more

HIF-1 signaling pathway Ferroptosis TGF-beta signaling pathway Mineral absorption Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Post-translational protein phosphorylation Iron uptake and transport Transferrin endocytosis and recycling +8 more

NF-kappa B signaling pathway HIF-1 signaling pathway Phagosome PI3K-Akt signaling pathway Necroptosis Neutrophil extracellular trap formation Toll-like receptor signaling pathway NOD-like receptor signaling pathway Alcoholic liver disease Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Legionellosis Yersinia infection Leishmaniasis Chagas disease Malaria Toxoplasmosis Amoebiasis Tuberculosis Hepatitis B Measles Influenza A Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Proteoglycans in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Inflammatory bowel disease Rheumatoid arthritis Lipid and atherosclerosis ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation +41 more

Antifolate resistance MAPK signaling pathway Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor NF-kappa B signaling pathway Sphingolipid signaling pathway mTOR signaling pathway Apoptosis Necroptosis TGF-beta signaling pathway Osteoclast differentiation Antigen processing and presentation Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway C-type lectin receptor signaling pathway Hematopoietic cell lineage Natural killer cell mediated cytotoxicity IL-17 signaling pathway T cell receptor signaling pathway Fc epsilon RI signaling pathway TNF signaling pathway Adipocytokine signaling pathway Type II diabetes mellitus Insulin resistance Non-alcoholic fatty liver disease AGE-RAGE signaling pathway in diabetic complications Alcoholic liver disease Type I diabetes mellitus Alzheimer disease Amyotrophic lateral sclerosis Prion disease Pathways of neurodegeneration - multiple diseases Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Legionellosis Yersinia infection Leishmaniasis Chagas disease African trypanosomiasis Malaria Toxoplasmosis Amoebiasis Tuberculosis Hepatitis C Hepatitis B Human cytomegalovirus infection Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Coronavirus disease - COVID-19 Proteoglycans in cancer Asthma Inflammatory bowel disease Systemic lupus erythematosus Rheumatoid arthritis Allograft rejection Graft-versus-host disease Hypertrophic cardiomyopathy Dilated cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production TNFR2 non-canonical NF-kB pathway Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling TNF signaling +72 more

The fatty acid cycling model The proton buffering model

Parathyroid hormone synthesis, secretion and action Endocrine and other factor-regulated calcium reabsorption Mineral absorption Tuberculosis Chemical carcinogenesis - receptor activation Vitamin D (calciferol) metabolism Nuclear Receptor transcription pathway SUMOylation of intracellular receptors +5 more

Protein processing in endoplasmic reticulum Non-alcoholic fatty liver disease Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases Lipid and atherosclerosis XBP1(S) activates chaperone genes IRE1alpha activates chaperones ATF6 (ATF6-alpha) activates chaperone genes +8 more

Lysosome Endocytosis Synaptic vesicle cycle Endocrine and other factor-regulated calcium reabsorption Huntington disease Bacterial invasion of epithelial cells Entry of Influenza Virion into Host Cell via Endocytosis Retrograde neurotrophin signalling Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance +18 more

Mucin type O-glycan biosynthesis Other types of O-glycan biosynthesis Metabolic pathways COPI-independent Golgi-to-ER retrograde traffic O-linked glycosylation of mucins +2 more

Glycerolipid metabolism Metabolic pathways Acyl chain remodeling of DAG and TAG

Ubiquitin mediated proteolysis Protein processing in endoplasmic reticulum Parkinson disease Pathways of neurodegeneration - multiple diseases E3 ubiquitin ligases ubiquitinate target proteins Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Antigen processing: Ubiquitination & Proteasome degradation +4 more