Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
ESOPHAGEAL CANCER	MONDO_0007576 133239	ACAD10	Unknown	21642993	GWAS catalog	Mitochondrial Fatty Acid Beta-Oxidation
		ADH1B	Unknown	19698717 32514122 34594039 37340002 40465716	GWAS catalog	Glycolysis / Gluconeogenesis Fatty acid degradation Tyrosine metabolism +7 more
		ALDH2	Unknown	19698717 32514122 34594039	GWAS catalog	Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Fatty acid degradation +14 more
		ANKRD11	Unknown	34290314	GWAS catalog	—
		ANP32A	Unknown	21642993	GWAS catalog	HuR (ELAVL1) binds and stabilizes mRNA
		ARHGEF10L	Unknown	33893285	GWAS catalog	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
		ASIP	Unknown	27197191 34290314	GWAS catalog	Melanogenesis
		ATP2A2	Unknown	34594039	GWAS catalog	Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +16 more
		ATXN2	Unknown	27197191 34290314	GWAS catalog	Amyotrophic lateral sclerosis Spinocerebellar ataxia Pathways of neurodegeneration - multiple diseases
		AZGP1	Unknown	37340002	GWAS catalog	Miscellaneous transport and binding events
		BABAM1	Unknown	27197191	GWAS catalog	Homologous recombination Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks +3 more
		BAD	Unknown	34290314	GWAS catalog	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +44 more
		BCL2L11	Unknown	34290314	GWAS catalog	EGFR tyrosine kinase inhibitor resistance FoxO signaling pathway PI3K-Akt signaling pathway +13 more
		BMAL1	Unknown	34594039	GWAS catalog	—
		BNC2	Unknown	33893285	GWAS catalog	—
		BPIFA3	Unknown	34290314	GWAS catalog	—
		BRCA2	Unknown	27197191 34290314	GWAS catalog	Homologous recombination Fanconi anemia pathway Pathways in cancer +7 more
		C11ORF65	Unknown	34290314	GWAS catalog	—
		CASP8	Unknown	33893285 34290314 34594039 37340002	GWAS catalog	Platinum drug resistance p53 signaling pathway Apoptosis +53 more
		CCDC170	Unknown	37340002	GWAS catalog	—
		CDK5RAP1	Unknown	34290314	GWAS catalog	—
		CELF2	Unknown	34290314	GWAS catalog	—
		CERS2	Unknown	34290314	GWAS catalog	Sphingolipid metabolism Metabolic pathways Sphingolipid signaling pathway +1 more
		CHMP4B	Unknown	34290314	GWAS catalog	Viral life cycle - HIV-1 Virion - Hepatitis viruses Endocytosis +6 more
		CLK1	Unknown	34290314	GWAS catalog	Legionellosis
		CSNK1A1	Unknown	21642993	GWAS catalog	Wnt signaling pathway Hedgehog signaling pathway Alzheimer disease +18 more
		CUX2	Unknown	37340002	GWAS catalog	—
		DCAF4	Unknown	34290314	GWAS catalog	Neddylation
		DCC	Unknown	—	HPO	Axon guidance Pathways in cancer Colorectal cancer +3 more
		DLGAP4	Unknown	34290314	GWAS catalog	Neurexins and neuroligins
		DPEP1	Unknown	34290314	GWAS catalog	Synthesis of Leukotrienes (LT) and Eoxins (EX) Aflatoxin activation and detoxification LTC4-CYSLTR mediated IL4 production
		EPB41L1	Unknown	33893285 34290314	GWAS catalog	Trafficking of AMPA receptors Neurexins and neuroligins
		EPHB6	Unknown	29299148	GWAS catalog	Axon guidance EPH-Ephrin signaling EPHB-mediated forward signaling +2 more
		ESR1	Unknown	37340002	GWAS catalog	Endocrine resistance Hormone signaling Estrogen signaling pathway +21 more
		FAM76B	Unknown	29299148	GWAS catalog	—
		FAM83C	Unknown	34290314	GWAS catalog	—
		FANCA	Unknown	33893285 34290314	GWAS catalog	Fanconi anemia pathway Fanconi Anemia Pathway
		FARP1	Unknown	34290314	GWAS catalog	—
		FBRSL1	Unknown	34290314	GWAS catalog	Polycomb repressive complex
		FGFR2	Unknown	34290314 37340002	GWAS catalog	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +26 more
		FIGLA	Unknown	34290314	GWAS catalog	—
		FLACC1	Unknown	34594039 37340002	GWAS catalog	—
		FOXP1	Unknown	34290314	GWAS catalog	MicroRNAs in cancer Transcriptional regulation of pluripotent stem cells
		FRY	Unknown	27197191	GWAS catalog	—
		FXN	Unknown	29299148	GWAS catalog	Porphyrin metabolism Mitochondrial protein import Mitochondrial iron-sulfur cluster biogenesis
		GOLPH3L	Unknown	34290314	GWAS catalog	—
		GPR137	Unknown	34290314	GWAS catalog	—
		GRHPR	Unknown	29299148	GWAS catalog	Glycine, serine and threonine metabolism Pyruvate metabolism Glyoxylate and dicarboxylate metabolism +2 more
		TGFBR2	Unknown	—	HPO	MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway +28 more
		WWOX	Unknown	—	HPO	Nuclear signaling by ERBB4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors
ESOPHAGEAL CARCINOMA	EFO_0002916	ACAD10	Unknown	21642993	GWAS catalog	Mitochondrial Fatty Acid Beta-Oxidation
		ADH1B	Unknown	19698717 22960999 32514122 34594039 37340002	GWAS catalog	Glycolysis / Gluconeogenesis Fatty acid degradation Tyrosine metabolism +7 more
		ALDH2	Unknown	19698717 32514122 34594039	GWAS catalog	Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Fatty acid degradation +14 more
		ANP32A	Unknown	21642993	GWAS catalog	HuR (ELAVL1) binds and stabilizes mRNA
		ATP2A2	Unknown	34594039	GWAS catalog	Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +16 more
		BMAL1	Unknown	34594039	GWAS catalog	—
		CASP8	Unknown	34594039 37340002	GWAS catalog	Platinum drug resistance p53 signaling pathway Apoptosis +53 more
		CSNK1A1	Unknown	21642993	GWAS catalog	Wnt signaling pathway Hedgehog signaling pathway Alzheimer disease +18 more
		CUX2	Unknown	37340002	GWAS catalog	—
		FLACC1	Unknown	34594039 37340002	GWAS catalog	—
MALIGNANT TUMOR OF ESOPHAGUS		TGFBR2	Causal	10097140 17460548 12154016 11956080 10213508 10789724 19558548	ClinVar	MAPK signaling pathway Cytokine-cytokine receptor interaction FoxO signaling pathway +28 more
		WWOX	Causal	11956080 17460548 10213508 12154016 10789724 10097140 19558548	ClinVar	Nuclear signaling by ERBB4 Negative regulation of activity of TFAP2 (AP-2) family transcription factors Activation of the TFAP2 (AP-2) family of transcription factors
		DCC	Unknown	—	ClinVar	Axon guidance Pathways in cancer Colorectal cancer +3 more

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Esophageal cancer

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