Subtype of: Endometrial cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
endometrial serous adenocarcinoma	MONDO_0006196	FBXW7	Unknown	36746489 33536036 23104009 22923510 25550841	Open Targets	Ubiquitin mediated proteolysis Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling +3 more
		FGFR2	Unknown	18552176 17525745	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +26 more
		FLNA	Unknown	23104009	Open Targets	MAPK signaling pathway Focal adhesion Salmonella infection +6 more
		FUS	Unknown	23104009	Open Targets	mRNA surveillance pathway Spliceosome Amyotrophic lateral sclerosis +3 more
		GAS7	Unknown	23104009	Open Targets	—
		GPC3	Unknown	23104009	Open Targets	Proteoglycans in cancer A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis +9 more
		GPC5	Unknown	23104009 22923510	Open Targets	A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG degradation +7 more
		GRM3	Unknown	23104009	Open Targets	Phospholipase D signaling pathway Neuroactive ligand-receptor interaction Glutamatergic synapse +3 more
		HGF	Unknown	23104009	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +29 more
		HIF1A	Unknown	23104009	Open Targets	HIF-1 signaling pathway Mitophagy - animal Autophagy - animal +19 more
		HRAS	Unknown	2064724	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		IL21R	Unknown	23104009	Open Targets	Cytokine-cytokine receptor interaction JAK-STAT signaling pathway Th17 cell differentiation +2 more
		IRS4	Unknown	23104009	Open Targets	cGMP-PKG signaling pathway FoxO signaling pathway Hormone signaling +11 more
		JAK2	Unknown	23104009	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		KAT6A	Unknown	23104009	Open Targets	Signaling pathways regulating pluripotency of stem cells HATs acetylate histones Regulation of TP53 Activity through Acetylation
		KAT7	Unknown	23104009	Open Targets	HATs acetylate histones
		KEAP1	Unknown	30908539	Open Targets	Ubiquitin mediated proteolysis Parkinson disease Pathways in cancer +6 more
		KMT2C	Unknown	23104009 22923510	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	29420467	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	25624430 1913654 21266528 22923510 35949786 22498935 22653804 9421075 2064724 23851676	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LATS1	Unknown	23104009	Open Targets	Hippo signaling pathway Hippo signaling pathway - multiple species Signaling by Hippo
		LEPROTL1	Unknown	22923510	Open Targets	—
		LHFPL6	Unknown	22923510	Open Targets	—
		LOC100506403	Unknown	28945609	Open Targets	—
		LPP	Unknown	23104009	Open Targets	—
		LRP1B	Unknown	23104009	Open Targets	—
		LSM14A	Unknown	22923510	Open Targets	—
		LZTR1	Unknown	23104009	Open Targets	—
		MACC1	Unknown	23104009	Open Targets	—
		MED12	Unknown	23104009	Open Targets	Thyroid hormone signaling pathway PPARA activates gene expression Generic Transcription Pathway +1 more
		MITF	Unknown	23104009	Open Targets	Mitophagy - animal Osteoclast differentiation Melanogenesis +4 more
		MLLT11	Unknown	23104009	Open Targets	—
		MTOR	Unknown	23104009	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MYH11	Unknown	22923510	Open Targets	Virion - Lassa virus and SFTS virus Vascular smooth muscle contraction Tight junction +6 more
		N4BP2	Unknown	23104009	Open Targets	—
		NCOA2	Unknown	22923510	Open Targets	Estrogen signaling pathway Thyroid hormone signaling pathway RORA activates gene expression +14 more
		NF1	Unknown	23104009	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NFKB2	Unknown	23104009	Open Targets	MAPK signaling pathway NF-kappa B signaling pathway Osteoclast differentiation +19 more
		NIN	Unknown	23104009	Open Targets	—
		NPM1	Unknown	28945609	Open Targets	Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere +2 more
		NRAS	Unknown	22271473	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NRG1	Unknown	23104009	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Amyotrophic lateral sclerosis +18 more
		NSD1	Unknown	23104009 22923510	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		NTRK1	Unknown	23104009	Open Targets	MAPK signaling pathway Ras signaling pathway Calcium signaling pathway +13 more
		NUMA1	Unknown	23104009	Open Targets	Recruitment of NuMA to mitotic centrosomes Mitotic Prophase
		NUP214	Unknown	23104009	Open Targets	Nucleocytoplasmic transport Amyotrophic lateral sclerosis ISG15 antiviral mechanism +26 more
		PAX7	Unknown	23104009	Open Targets	Transcriptional misregulation in cancer
		PDGFRA	Unknown	22923510	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +30 more
		PIK3CA	Unknown	36746489 25624430 25078343 21266528 22923510 30908539 35949786 19272638 26975040 22498935 22271473 30710169 22653804 19839777 23104009 29420467 36238840 21435433	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3CB	Unknown	23104009	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +126 more

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Endometrial serous adenocarcinoma

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