Subtype of: Endometrial cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
endometrial endometrioid adenocarcinoma	MONDO_0006192	PMS1	Unknown	28481359	Open Targets	—
		PMS2	Unknown	28481359	Open Targets	Mismatch repair Fanconi anemia pathway Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) +3 more
		POLD1	Unknown	26748215 28481359	Open Targets	DNA replication Base excision repair Nucleotide excision repair +19 more
		POLE	Unknown	28795426 25224212 38571325 30908539 25720322 27159395 25194673 32457342 30710169 26748215 27006490 24844595 37328769 37298034 36765365 26763250 27894751 33016334 28481359 37042153	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		PPM1D	Unknown	29420467 28481359	Open Targets	p53 signaling pathway Transcriptional regulation by RUNX2
		PPP2R1A	Unknown	21381030 25720322 30710169 22653804 21882256 33016334 28481359 21435433	Open Targets	mRNA surveillance pathway Sphingolipid signaling pathway Cell cycle +52 more
		PPP6C	Unknown	28481359	Open Targets	COPII-mediated vesicle transport
		PRDM1	Unknown	36142641 33016334 28481359 27159395	Open Targets	Regulation of TP53 Expression
		PRDM16	Unknown	33016334	Open Targets	Lysine degradation Metabolic pathways Thermogenesis +1 more
		PRDM2	Unknown	33016334	Open Targets	Lysine degradation Metabolic pathways
		PREX2	Unknown	33016334 27159395	Open Targets	Regulation of PTEN stability and activity
		PRF1	Unknown	33016334	Open Targets	Apoptosis Natural killer cell mediated cytotoxicity Type I diabetes mellitus +4 more
		PRKAR1A	Unknown	28481359	Open Targets	Insulin signaling pathway PKA activation PKA activation in glucagon signalling +7 more
		PRKD1	Unknown	33016334	Open Targets	Rap1 signaling pathway Aldosterone synthesis and secretion Chemical carcinogenesis - reactive oxygen species +1 more
		PRPF40B	Unknown	33016334	Open Targets	Spliceosome
		PTCH1	Unknown	33016334 28481359	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Axon guidance +7 more
		PTEN	Unknown	11555573 30886885 20062086 16021566 21266528 27159395 10746673 11006040 32616873 37298034 27302833 21468130 18084252 35953603 22766790 28103826 17219201 30710169 33536036 22635024 22653804 18500270 15923161 22807394 29876005 27566247 36238840 9829719 18757403 21470976 9887237 11190805 9354433 23949151 30908539 9765621 22498935 15069681 23733133 12015762 18980800 23674493 11156411 29162652 32909971 36142641 37328769 33016334 28481359 9307275	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +37 more
		PTPN11	Unknown	28481359 36238840	Open Targets	Ras signaling pathway Phospholipase D signaling pathway Efferocytosis +56 more
		PTPRB	Unknown	29162652	Open Targets	Adherens junction Neutrophil degranulation
		PTPRD	Unknown	33016334 28481359	Open Targets	Cell adhesion molecules Receptor-type tyrosine-protein phosphatases Synaptic adhesion-like molecules
		PTPRT	Unknown	37328769 33016334 28481359 28103826	Open Targets	—
		PWWP2A	Unknown	33016334	Open Targets	—
		QKI	Unknown	33016334	Open Targets	Signaling by BRAF and RAF fusions
		RAD21	Unknown	28481359	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		RAD50	Unknown	28481359	Open Targets	Homologous recombination Non-homologous end-joining Cellular senescence +14 more
		RAD51B	Unknown	28481359	Open Targets	Homologous recombination HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) +4 more
		RAD51C	Unknown	28481359	Open Targets	Homologous recombination Fanconi anemia pathway HDR through Homologous Recombination (HRR) +5 more
		RAF1	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +93 more
		RANBP2	Unknown	33016334	Open Targets	Nucleocytoplasmic transport Viral life cycle - HIV-1 Amyotrophic lateral sclerosis +32 more
		RARA	Unknown	28481359	Open Targets	Th17 cell differentiation Estrogen signaling pathway Pathways in cancer +6 more
		RASA1	Unknown	33016334 28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Axon guidance +5 more
		RB1	Unknown	33016334 28481359 32909971	Open Targets	Endocrine resistance Cell cycle Cellular senescence +30 more
		RBM10	Unknown	33016334 28481359 27159395	Open Targets	—
		RECQL4	Unknown	28481359	Open Targets	—
		REL	Unknown	28481359	Open Targets	Ras signaling pathway Transcriptional misregulation in cancer Viral carcinogenesis +1 more
		RET	Unknown	33016334 28481359 35953603	Open Targets	MAPK signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway +6 more
		RGS7	Unknown	33016334	Open Targets	G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
		RHOA	Unknown	28481359	Open Targets	Ras signaling pathway Rap1 signaling pathway cGMP-PKG signaling pathway +64 more
		RICTOR	Unknown	28481359	Open Targets	mTOR signaling pathway PIP3 activates AKT signaling CD28 dependent PI3K/Akt signaling +3 more
		RMI2	Unknown	33016334 28481359	Open Targets	Fanconi anemia pathway HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) +7 more
		RNF213	Unknown	33016334	Open Targets	Suppression of apoptosis Antigen processing: Ubiquitination & Proteasome degradation
		RNF43	Unknown	33016334 28481359 32909971	Open Targets	Wnt signaling pathway Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation
		ROBO2	Unknown	33016334	Open Targets	Axon guidance Signaling by ROBO receptors Regulation of commissural axon pathfinding by SLIT and ROBO
		ROS1	Unknown	28481359 35953603	Open Targets	—
		RPL10	Unknown	33016334	Open Targets	Ribosome Coronavirus disease - COVID-19 L13a-mediated translational silencing of Ceruloplasmin expression +7 more
		RRAS2	Unknown	33016334	Open Targets	MAPK signaling pathway Ras signaling pathway cAMP signaling pathway +8 more
		SALL4	Unknown	33016334	Open Targets	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Transcriptional regulation of pluripotent stem cells Regulation of PTEN gene transcription
		SDHA	Unknown	28481359 27159395	Open Targets	Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways +12 more
		SDHAF2	Unknown	33016334	Open Targets	—
		SDHB	Unknown	28481359	Open Targets	Citrate cycle (TCA cycle) Oxidative phosphorylation Metabolic pathways +12 more

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Endometrial endometrioid adenocarcinoma

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