Subtype of: Endometrial cancer

Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
endometrial clear cell adenocarcinoma	MONDO_0006191	FGFR4	Unknown	28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +20 more
		FLT3	Unknown	28481359	Open Targets	MAPK signaling pathway Ras signaling pathway PI3K-Akt signaling pathway +8 more
		FLT4	Unknown	28481359	Open Targets	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +6 more
		GLI1	Unknown	28481359	Open Targets	cAMP signaling pathway Hedgehog signaling pathway Pathways in cancer +5 more
		GSK3B	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance ErbB signaling pathway Chemokine signaling pathway +59 more
		HNF1A	Unknown	28485815 28481359	Open Targets	Maturity onset diabetes of the young
		HSP90AB1	Unknown	28485815	Open Targets	Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Necroptosis +26 more
		IDH1	Unknown	28481359	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +9 more
		IDH2	Unknown	28481359	Open Targets	Citrate cycle (TCA cycle) Glutathione metabolism Metabolic pathways +7 more
		IRF4	Unknown	28481359	Open Targets	Th17 cell differentiation Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling +1 more
		JAK1	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance PI3K-Akt signaling pathway Necroptosis +48 more
		JAK2	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway Hormone signaling +51 more
		JAK3	Unknown	28481359	Open Targets	Chemokine signaling pathway PI3K-Akt signaling pathway Necroptosis +21 more
		KDM5A	Unknown	28481359	Open Targets	HDMs demethylate histones
		KDM5C	Unknown	28481359	Open Targets	HDMs demethylate histones
		KMT2C	Unknown	28485815 28481359	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		KMT2D	Unknown	28481359	Open Targets	Lysine degradation Metabolic pathways Cushing syndrome +4 more
		KRAS	Unknown	25308272 31269413 21266528 7960232 1581890 33536036 22271473 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +134 more
		LOC100506403	Unknown	29420467 28481359	Open Targets	—
		MAP3K1	Unknown	28485815	Open Targets	MAPK signaling pathway Ubiquitin mediated proteolysis Tight junction +11 more
		MAP3K13	Unknown	28481359	Open Targets	MAPK signaling pathway
		MDM4	Unknown	28481359	Open Targets	p53 signaling pathway MicroRNAs in cancer Oxidative Stress Induced Senescence +6 more
		MEN1	Unknown	28481359	Open Targets	Cushing syndrome Transcriptional misregulation in cancer Formation of the beta-catenin:TCF transactivating complex +5 more
		MET	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +37 more
		MITF	Unknown	28481359	Open Targets	Mitophagy - animal Osteoclast differentiation Melanogenesis +4 more
		MLH1	Unknown	27302833 28481359 25194673	Open Targets	Platinum drug resistance Mismatch repair Fanconi anemia pathway +8 more
		MSH2	Unknown	27302833 28481359	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +7 more
		MSH6	Unknown	27302833 23104009 28481359	Open Targets	Platinum drug resistance Mismatch repair Pathways in cancer +4 more
		MTOR	Unknown	28485815 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +61 more
		MYCL	Unknown	28481359	Open Targets	—
		NCOR1	Unknown	28481359	Open Targets	Endocrine resistance TGF-beta signaling pathway Thyroid hormone signaling pathway +16 more
		NF1	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +2 more
		NFE2L2	Unknown	28481359	Open Targets	Protein processing in endoplasmic reticulum Parkinson disease Pathways in cancer +4 more
		NOTCH1	Unknown	28481359	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +20 more
		NOTCH2	Unknown	28481359	Open Targets	Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation +13 more
		NRAS	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +130 more
		NSD2	Unknown	28485815	Open Targets	Lysine degradation Metabolic pathways Transcriptional misregulation in cancer +5 more
		PATZ1	Unknown	28485815	Open Targets	—
		PAX5	Unknown	28481359	Open Targets	Transcriptional misregulation in cancer RUNX1 regulates transcription of genes involved in BCR signaling
		PDGFRB	Unknown	28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway +22 more
		PIK3CA	Unknown	25308272 28485815 31269413 25078343 21266528 22271473 22498935 25473756 27302833 28481359	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +149 more
		PIK3CB	Unknown	28481359	Open Targets	Inositol phosphate metabolism Metabolic pathways EGFR tyrosine kinase inhibitor resistance +126 more
		PIK3R1	Unknown	28485815 25308272 28481359 21478295	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +150 more
		PLEC	Unknown	28485815	Open Targets	Cytoskeleton in muscle cells Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins +1 more
		PMS1	Unknown	28481359	Open Targets	—
		POLE	Unknown	25308272 28485815 26763250 32457342 25720322	Open Targets	DNA replication Base excision repair Nucleotide excision repair +10 more
		PPM1D	Unknown	28481359	Open Targets	p53 signaling pathway Transcriptional regulation by RUNX2
		PPP2R1A	Unknown	25308272 28485815 25720322 28481359	Open Targets	mRNA surveillance pathway Sphingolipid signaling pathway Cell cycle +52 more
		PREX2	Unknown	28485815	Open Targets	Regulation of PTEN stability and activity
		PRKAR1A	Unknown	28481359	Open Targets	Insulin signaling pathway PKA activation PKA activation in glucagon signalling +7 more

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Endometrial clear cell adenocarcinoma

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