Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
duodenal adenocarcinoma	MONDO_0006186	CTNND2	Unknown	36991000 26804919	Open Targets	Wnt signaling pathway
		CUL3	Unknown	36991000	Open Targets	Ubiquitin mediated proteolysis Hedgehog signaling pathway Degradation of DVL +4 more
		CUX1	Unknown	36991000 26804919	Open Targets	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Intra-Golgi traffic
		CXCR4	Unknown	36991000 26804919	Open Targets	Viral life cycle - HIV-1 Virion - Human immunodeficiency virus Calcium signaling pathway +15 more
		CYLD	Unknown	36991000	Open Targets	NF-kappa B signaling pathway Necroptosis Osteoclast differentiation +9 more
		CYP2C8	Unknown	36991000	Open Targets	Arachidonic acid metabolism Linoleic acid metabolism Retinol metabolism +10 more
		DAXX	Unknown	36991000	Open Targets	MAPK signaling pathway Apoptosis Parkinson disease +6 more
		DCAF12L2	Unknown	36991000 26804919	Open Targets	—
		DCC	Unknown	36991000	Open Targets	Axon guidance Pathways in cancer Colorectal cancer +3 more
		DCTN1	Unknown	36991000	Open Targets	Motor proteins Vasopressin-regulated water reabsorption Amyotrophic lateral sclerosis +15 more
		DDB2	Unknown	36991000 26804919	Open Targets	Nucleotide excision repair p53 signaling pathway Ubiquitin mediated proteolysis +23 more
		DDIT3	Unknown	36991000	Open Targets	MAPK signaling pathway Protein processing in endoplasmic reticulum Apoptosis +9 more
		DDR2	Unknown	36991000	Open Targets	Non-integrin membrane-ECM interactions
		DDX10	Unknown	36991000	Open Targets	—
		DDX3X	Unknown	36991000	Open Targets	RIG-I-like receptor signaling pathway Hepatitis B Viral carcinogenesis +1 more
		DDX5	Unknown	36991000	Open Targets	Spliceosome Transcriptional misregulation in cancer Proteoglycans in cancer +3 more
		DDX6	Unknown	36991000	Open Targets	RNA degradation mRNA decay by 5' to 3' exoribonuclease
		DEK	Unknown	36991000	Open Targets	B-WICH complex positively regulates rRNA expression Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Transcriptional regulation of granulopoiesis
		DGCR8	Unknown	36991000	Open Targets	MicroRNA (miRNA) biogenesis
		DICER1	Unknown	36991000	Open Targets	MicroRNAs in cancer MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis
		DNM2	Unknown	36991000 26804919	Open Targets	Phospholipase D signaling pathway Endocytosis Fc gamma R-mediated phagocytosis +13 more
		DNMT3A	Unknown	36991000 28481359	Open Targets	Cysteine and methionine metabolism Metabolic pathways Efferocytosis +3 more
		DROSHA	Unknown	36991000 26804919	Open Targets	Ribosome biogenesis in eukaryotes Proteoglycans in cancer MicroRNA (miRNA) biogenesis
		EBF1	Unknown	36991000 26804919	Open Targets	—
		ECT2L	Unknown	36991000	Open Targets	—
		EED	Unknown	36991000	Open Targets	Polycomb repressive complex PRC2 methylates histones and DNA Oxidative Stress Induced Senescence +4 more
		EGFR	Unknown	22422135 36991000	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Virion - Hepatitis viruses +79 more
		EIF4A2	Unknown	36991000	Open Targets	ISG15 antiviral mechanism L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA +4 more
		ELF3	Unknown	36991000 26804919	Open Targets	Pre-NOTCH Transcription and Translation
		ELF4	Unknown	36991000	Open Targets	—
		ELK4	Unknown	36991000	Open Targets	MAPK signaling pathway Human T-cell leukemia virus 1 infection Transcriptional misregulation in cancer
		ELL	Unknown	36991000	Open Targets	Viral life cycle - HIV-1 Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events +4 more
		ELN	Unknown	36991000	Open Targets	Cytoskeleton in muscle cells Protein digestion and absorption Degradation of the extracellular matrix +2 more
		EML4	Unknown	36991000 26804919	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer +1 more
		EP300	Unknown	36991000 28481359 26804919	Open Targets	Polycomb repressive complex Viral life cycle - HIV-1 cAMP signaling pathway +66 more
		EPAS1	Unknown	36991000 26804919	Open Targets	HIF-1 signaling pathway Pathways in cancer Renal cell carcinoma +6 more
		EPHA3	Unknown	36991000 28481359 26804919	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		EPHA7	Unknown	26998897 36991000	Open Targets	Axon guidance EPH-Ephrin signaling EPHA-mediated growth cone collapse +1 more
		EPS15	Unknown	36991000	Open Targets	Endocytosis EGFR downregulation Negative regulation of MET activity +2 more
		ERBB2	Unknown	26804919 36991000 26315110 30352910 29420467 26998897 24797764 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +48 more
		ERBB3	Unknown	36991000 28481359 32561076 26804919	Open Targets	EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway ErbB signaling pathway +19 more
		ERBB4	Unknown	36991000 28481359 26804919	Open Targets	MAPK signaling pathway ErbB signaling pathway Calcium signaling pathway +22 more
		ERC1	Unknown	36991000	Open Targets	NF-kappa B signaling pathway
		ERCC2	Unknown	36991000 28481359 26804919	Open Targets	Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex +19 more
		ERCC3	Unknown	36991000	Open Targets	Basal transcription factors Nucleotide excision repair Formation of RNA Pol II elongation complex +19 more
		ERCC4	Unknown	36991000	Open Targets	Nucleotide excision repair Fanconi anemia pathway HDR through Single Strand Annealing (SSA) +4 more
		ERCC5	Unknown	36991000 26804919	Open Targets	Nucleotide excision repair Formation of Incision Complex in GG-NER Dual Incision in GG-NER +1 more
		ERG	Unknown	36991000 28481359 26804919	Open Targets	Transcriptional misregulation in cancer Prostate cancer
		ESR1	Unknown	26998897 36991000 26804919	Open Targets	Endocrine resistance Hormone signaling Estrogen signaling pathway +21 more
		ETNK1	Unknown	36991000	Open Targets	Glycerophospholipid metabolism Metabolic pathways Synthesis of PE

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Duodenal adenocarcinoma

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