Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
duodenal adenocarcinoma	MONDO_0006186	A1CF	Unknown	36991000	Open Targets	mRNA Editing: C to U Conversion Formation of the Editosome
		ABI1	Unknown	36991000	Open Targets	Pathogenic Escherichia coli infection Salmonella infection Regulation of actin dynamics for phagocytic cup formation +3 more
		ABL1	Unknown	36991000 28481359 26804919	Open Targets	ErbB signaling pathway Ras signaling pathway Cell cycle +17 more
		ABL2	Unknown	36991000	Open Targets	ErbB signaling pathway Ras signaling pathway Chemical carcinogenesis - reactive oxygen species +2 more
		ACKR3	Unknown	26804919	Open Targets	Cytokine-cytokine receptor interaction Viral protein interaction with cytokine and cytokine receptor Chemokine receptors bind chemokines +1 more
		ACSL3	Unknown	36991000 26804919	Open Targets	Fatty acid biosynthesis Fatty acid degradation Metabolic pathways +8 more
		ACSL6	Unknown	36991000	Open Targets	Fatty acid biosynthesis Fatty acid degradation Metabolic pathways +7 more
		ACVR1	Unknown	36991000	Open Targets	Cytokine-cytokine receptor interaction Hormone signaling TGF-beta signaling pathway +2 more
		ACVR1B	Unknown	36991000 26804919	Open Targets	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells +1 more
		ACVR2A	Unknown	26998897 36991000 19852062 12615714 26804919	Open Targets	Cytokine-cytokine receptor interaction TGF-beta signaling pathway Signaling pathways regulating pluripotency of stem cells +3 more
		AFDN	Unknown	36991000 26804919	Open Targets	Ras signaling pathway Rap1 signaling pathway cAMP signaling pathway +4 more
		AFF1	Unknown	26998897 36991000	Open Targets	Transcriptional misregulation in cancer
		AFF3	Unknown	26998897 36991000 26804919	Open Targets	—
		AFF4	Unknown	26998897 36991000 26804919	Open Targets	Viral life cycle - HIV-1 Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events +1 more
		AKAP9	Unknown	26998897 36991000 26804919	Open Targets	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes +7 more
		AKT1	Unknown	36991000	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +131 more
		AKT2	Unknown	36991000	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +122 more
		ALDH2	Unknown	36991000	Open Targets	Glycolysis / Gluconeogenesis Ascorbate and aldarate metabolism Fatty acid degradation +14 more
		ALK	Unknown	36991000 28481359 26804919	Open Targets	Pathways in cancer Non-small cell lung cancer PD-L1 expression and PD-1 checkpoint pathway in cancer
		AMER1	Unknown	36991000 26804919	Open Targets	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane +8 more
		ANK1	Unknown	36991000 26804919	Open Targets	Proteoglycans in cancer Interaction between L1 and Ankyrins Neurofascin interactions +1 more
		APC	Unknown	27984236 26804919 36991000 26315110 35778698 26998897 24797764 28481359	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		AR	Unknown	26998897 36991000 28481359	Open Targets	Oocyte meiosis Pathways in cancer Chemical carcinogenesis - receptor activation +7 more
		ARAF	Unknown	36991000 28481359 26804919	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +41 more
		ARHGAP26	Unknown	36991000	Open Targets	Rho GTPase cycle
		ARHGAP35	Unknown	36991000 26804919	Open Targets	Focal adhesion Platelet activation Leukocyte transendothelial migration +4 more
		ARHGAP5	Unknown	26804919	Open Targets	Focal adhesion Leukocyte transendothelial migration Rho GTPase cycle
		ARHGEF10	Unknown	36991000 26804919	Open Targets	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
		ARHGEF10L	Unknown	36991000	Open Targets	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
		ARHGEF12	Unknown	36991000 26804919	Open Targets	Vascular smooth muscle contraction Axon guidance Platelet activation +12 more
		ARID1A	Unknown	26998897 36991000 28481359 26804919	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID1B	Unknown	36991000 28481359 26804919	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		ARID2	Unknown	26998897 36991000 28481359 26804919	Open Targets	ATP-dependent chromatin remodeling Hepatocellular carcinoma RMTs methylate histone arginines +1 more
		ARNT	Unknown	36991000	Open Targets	HIF-1 signaling pathway Efferocytosis Cushing syndrome +10 more
		ASPM	Unknown	36991000 26804919	Open Targets	—
		ASPSCR1	Unknown	36991000	Open Targets	Transcriptional misregulation in cancer
		ASXL1	Unknown	36991000 28481359	Open Targets	Polycomb repressive complex UCH proteinases
		ASXL2	Unknown	36991000 28481359	Open Targets	Polycomb repressive complex UCH proteinases
		ATIC	Unknown	36991000	Open Targets	Purine metabolism One carbon pool by folate Metabolic pathways +2 more
		ATM	Unknown	36991000 28481359 26804919	Open Targets	Platinum drug resistance Homologous recombination NF-kappa B signaling pathway +33 more
		ATP1A1	Unknown	36991000 26804919	Open Targets	cGMP-PKG signaling pathway cAMP signaling pathway Cardiac muscle contraction +18 more
		ATP2B3	Unknown	36991000	Open Targets	Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway +9 more
		ATR	Unknown	36991000 28481359 26804919	Open Targets	Fanconi anemia pathway Cell cycle p53 signaling pathway +13 more
		ATRX	Unknown	36991000 28481359	Open Targets	Cell cycle
		AXIN1	Unknown	36991000 28481359 26804919	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +28 more
		AXIN2	Unknown	36991000 26804919	Open Targets	Wnt signaling pathway Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells +15 more
		B2M	Unknown	36991000 26804919	Open Targets	Antigen processing and presentation Human cytomegalovirus infection Human T-cell leukemia virus 1 infection +14 more
		BAP1	Unknown	36991000	Open Targets	Polycomb repressive complex UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
		BARD1	Unknown	36991000 26804919	Open Targets	Homologous recombination HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) +11 more
		BAX	Unknown	36991000 19852062 15063132 26804919	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance +52 more

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Duodenal adenocarcinoma

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