Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
duodenal adenocarcinoma	MONDO_0006186	SETBP1	Unknown	36991000 26804919	Open Targets	—
		SETD1B	Unknown	36991000 26804919	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines +1 more
		SETD2	Unknown	36991000	Open Targets	Lysine degradation Metabolic pathways PKMTs methylate histone lysines
		SETDB1	Unknown	26998897 36991000 26804919	Open Targets	Lysine degradation Metabolic pathways Signaling pathways regulating pluripotency of stem cells +1 more
		SF3B1	Unknown	36991000 28481359 26804919	Open Targets	Spliceosome B-WICH complex positively regulates rRNA expression mRNA Splicing - Major Pathway +1 more
		SFPQ	Unknown	36991000	Open Targets	PTK6 Regulates Proteins Involved in RNA Processing Suppression of apoptosis
		SGK1	Unknown	36991000	Open Targets	FoxO signaling pathway Efferocytosis mTOR signaling pathway +6 more
		SH2B3	Unknown	28481359	Open Targets	Neurotrophin signaling pathway Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production
		SH3GL1	Unknown	36991000	Open Targets	Endocytosis EGFR downregulation Negative regulation of MET activity +2 more
		SHTN1	Unknown	36991000	Open Targets	—
		SIRPA	Unknown	36991000	Open Targets	Efferocytosis Osteoclast differentiation Cell surface interactions at the vascular wall +2 more
		SIX1	Unknown	36991000	Open Targets	Transcriptional misregulation in cancer
		SIX2	Unknown	26804919	Open Targets	—
		SKI	Unknown	36991000	Open Targets	TGF-beta signaling pathway Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity
		SLC34A2	Unknown	36991000	Open Targets	Parathyroid hormone synthesis, secretion and action Mineral absorption Type II Na+/Pi cotransporters +2 more
		SLC45A3	Unknown	36991000 26804919	Open Targets	Transcriptional misregulation in cancer MicroRNAs in cancer Cellular hexose transport
		SMAD2	Unknown	36991000 28481359	Open Targets	Cell cycle Endocytosis Cellular senescence +30 more
		SMAD3	Unknown	36991000 28481359	Open Targets	FoxO signaling pathway Cell cycle Endocytosis +34 more
		SMAD4	Unknown	26804919 36991000 26315110 24797764 28481359 15014009	Open Targets	FoxO signaling pathway Hormone signaling Cell cycle +30 more
		SMARCA4	Unknown	36991000 28481359 26804919	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +6 more
		SMARCB1	Unknown	36991000 26804919	Open Targets	ATP-dependent chromatin remodeling Viral life cycle - HIV-1 Thermogenesis +3 more
		SMARCD1	Unknown	36991000	Open Targets	ATP-dependent chromatin remodeling Thermogenesis Hepatocellular carcinoma +2 more
		SMC1A	Unknown	36991000	Open Targets	Cell cycle Oocyte meiosis Separation of Sister Chromatids +5 more
		SMO	Unknown	36991000 28481359 26804919	Open Targets	Hedgehog signaling pathway Axon guidance Pathways in cancer +6 more
		SND1	Unknown	36991000	Open Targets	Viral carcinogenesis Signaling by BRAF and RAF fusions
		SNX29	Unknown	36991000 26804919	Open Targets	—
		SOCS1	Unknown	36991000	Open Targets	Ubiquitin mediated proteolysis Osteoclast differentiation JAK-STAT signaling pathway +13 more
		SOS1	Unknown	36991000	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway +97 more
		SOX2	Unknown	26804919	Open Targets	Hippo signaling pathway Signaling pathways regulating pluripotency of stem cells POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation +4 more
		SPECC1	Unknown	36991000 26804919	Open Targets	—
		SPEN	Unknown	26998897 36991000 28481359 26804919	Open Targets	Notch signaling pathway
		SPOP	Unknown	36991000	Open Targets	Hedgehog signaling pathway Hedgehog 'on' state
		SRC	Unknown	26998897 36991000 28481359 26804919	Open Targets	EGFR tyrosine kinase inhibitor resistance Endocrine resistance ErbB signaling pathway +92 more
		SRGAP3	Unknown	36991000 26804919	Open Targets	Axon guidance Rho GTPase cycle
		SS18	Unknown	36991000	Open Targets	ATP-dependent chromatin remodeling Transcriptional misregulation in cancer
		SS18L1	Unknown	36991000	Open Targets	ATP-dependent chromatin remodeling Transcriptional misregulation in cancer
		SSX1	Unknown	36991000	Open Targets	Transcriptional misregulation in cancer
		STAG1	Unknown	36991000	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		STAG2	Unknown	36991000 28481359 26804919	Open Targets	Cell cycle Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion +4 more
		STAT3	Unknown	36991000 28481359	Open Targets	EGFR tyrosine kinase inhibitor resistance Chemokine signaling pathway HIF-1 signaling pathway +53 more
		STAT5B	Unknown	36991000 26804919	Open Targets	ErbB signaling pathway Chemokine signaling pathway Hormone signaling +28 more
		STAT6	Unknown	36991000	Open Targets	Necroptosis JAK-STAT signaling pathway Th1 and Th2 cell differentiation +7 more
		STIL	Unknown	36991000	Open Targets	—
		STK11	Unknown	24797764	Open Targets	FoxO signaling pathway Hormone signaling Autophagy - animal +9 more
		STRN	Unknown	36991000	Open Targets	PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling +2 more
		SUB1	Unknown	36991000	Open Targets	—
		SUFU	Unknown	36991000	Open Targets	Hedgehog signaling pathway Pathways in cancer Basal cell carcinoma +4 more
		SUZ12	Unknown	36991000 28481359	Open Targets	Polycomb repressive complex PRC2 methylates histones and DNA Oxidative Stress Induced Senescence +5 more
		SYK	Unknown	36991000 26804919	Open Targets	NF-kappa B signaling pathway Phospholipase D signaling pathway PI3K-Akt signaling pathway +30 more
		TBL1XR1	Unknown	26804919	Open Targets	Wnt signaling pathway RORA activates gene expression PPARA activates gene expression +11 more

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Duodenal adenocarcinoma

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