Diabetes mellitus

ABC transporters ABC transporters in lipid homeostasis Defective ABCA12 causes autosomal recessive congenital ichthyosis type 4B

ABC transporters Mitochondrial ABC transporters

ABC transporters Insulin secretion Type II diabetes mellitus ATP sensitive Potassium channels Regulation of insulin secretion Defective ABCC8 can cause hypoglycemias and hyperglycemias +3 more

Glycosphingolipid biosynthesis - lacto and neolacto series Glycosphingolipid biosynthesis - globo and isoglobo series Metabolic pathways ABO blood group biosynthesis +1 more

Thiamine metabolism Riboflavin metabolism Metabolic pathways Adherens junction Chemical carcinogenesis - reactive oxygen species +2 more

Fatty acid biosynthesis Fatty acid degradation Metabolic pathways Fatty acid metabolism PPAR signaling pathway Peroxisome Ferroptosis Thermogenesis Adipocytokine signaling pathway PPARA activates gene expression Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Synthesis of very long-chain fatty acyl-CoAs +10 more

Purine metabolism Metabolic pathways Endocrine resistance Rap1 signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Chemokine signaling pathway Phospholipase D signaling pathway Hormone signaling Oocyte meiosis Longevity regulating pathway Longevity regulating pathway - multiple species Adrenergic signaling in cardiomyocytes Vascular smooth muscle contraction Apelin signaling pathway Gap junction Platelet activation Circadian entrainment Thermogenesis Retrograde endocannabinoid signaling Glutamatergic synapse Cholinergic synapse Serotonergic synapse GABAergic synapse Dopaminergic synapse Inflammatory mediator regulation of TRP channels Insulin secretion GnRH signaling pathway Ovarian steroidogenesis Progesterone-mediated oocyte maturation Estrogen signaling pathway Melanogenesis Thyroid hormone synthesis Oxytocin signaling pathway Regulation of lipolysis in adipocytes Renin secretion Aldosterone synthesis and secretion Relaxin signaling pathway Cortisol synthesis and secretion Parathyroid hormone synthesis, secretion and action Cushing syndrome Growth hormone synthesis, secretion and action Salivary secretion Gastric acid secretion Pancreatic secretion Bile secretion Parkinson disease Cocaine addiction Amphetamine addiction Morphine addiction Alcoholism Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Pathways in cancer Chemical carcinogenesis - receptor activation Dilated cardiomyopathy Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis +66 more

PPAR signaling pathway Hormone signaling AMPK signaling pathway Longevity regulating pathway Adipocytokine signaling pathway Type II diabetes mellitus Non-alcoholic fatty liver disease Alcoholic liver disease AMPK inhibits chREBP transcriptional activation activity Transcriptional regulation of white adipocyte differentiation +7 more

Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling Adrenergic signaling in cardiomyocytes Gap junction Regulation of lipolysis in adipocytes Renin secretion Salivary secretion Chemical carcinogenesis - receptor activation Dilated cardiomyopathy Adrenoceptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production +12 more

Triglyceride biosynthesis

Retinol metabolism Metabolic pathways RA biosynthesis pathway

Alpha-protein kinase 1 signaling pathway

Proteoglycans in cancer Interaction between L1 and Ankyrins Neurofascin interactions COPI-mediated anterograde transport +1 more

Miscellaneous transport and binding events

Efferocytosis Stimuli-sensing channels

Glycine, serine and threonine metabolism Tyrosine metabolism Phenylalanine metabolism beta-Alanine metabolism Metabolic pathways Phase I - Functionalization of compounds +3 more

Lysosome

Fat digestion and absorption Vitamin digestion and absorption Cholesterol metabolism Lipid and atherosclerosis Cell surface interactions at the vascular wall Scavenging by Class B Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class H Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Platelet sensitization by LDL Regulation of TLR by endogenous ligand Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDL assembly Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance LDL clearance LDL remodeling VLDL clearance Retinoid metabolism and transport +20 more

Cholesterol metabolism VLDL assembly VLDL clearance NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux +1 more

Cholesterol metabolism Alzheimer disease Nuclear signaling by ERBB4 Scavenging by Class A Receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors Post-translational protein phosphorylation Chylomicron assembly Chylomicron remodeling Chylomicron clearance HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Retinoid metabolism and transport +10 more

Endocytosis Rho GTPase cycle PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1

Melanogenesis

Calcium signaling pathway cGMP-PKG signaling pathway cAMP signaling pathway Adrenergic signaling in cardiomyocytes Aldosterone synthesis and secretion Endocrine and other factor-regulated calcium reabsorption Salivary secretion Pancreatic secretion Mineral absorption Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases +9 more

Oxidative phosphorylation Metabolic pathways Thermogenesis Alzheimer disease Parkinson disease Amyotrophic lateral sclerosis Huntington disease Prion disease Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Diabetic cardiomyopathy Formation of ATP by chemiosmotic coupling Cristae formation +10 more

Ub-specific processing proteases

Polycomb repressive complex RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known

ATP-dependent chromatin remodeling B-WICH complex positively regulates rRNA expression Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks

Rap1 signaling pathway Chemokine signaling pathway Efferocytosis Focal adhesion Leukocyte transendothelial migration Regulation of actin cytoskeleton Growth hormone synthesis, secretion and action Bacterial invasion of epithelial cells Shigellosis Yersinia infection Human cytomegalovirus infection Downstream signal transduction p130Cas linkage to MAPK signaling for integrins VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases +12 more

EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance NF-kappa B signaling pathway HIF-1 signaling pathway Sphingolipid signaling pathway p53 signaling pathway Autophagy - animal Protein processing in endoplasmic reticulum PI3K-Akt signaling pathway Apoptosis Apoptosis - multiple species Necroptosis Adrenergic signaling in cardiomyocytes Hedgehog signaling pathway Focal adhesion NOD-like receptor signaling pathway JAK-STAT signaling pathway Neurotrophin signaling pathway Cholinergic synapse Estrogen signaling pathway Parathyroid hormone synthesis, secretion and action AGE-RAGE signaling pathway in diabetic complications Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Shigellosis Salmonella infection Toxoplasmosis Tuberculosis Hepatitis B Measles Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Colorectal cancer Prostate cancer Small cell lung cancer Gastric cancer Lipid and atherosclerosis Fluid shear stress and atherosclerosis Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling +46 more

C-type lectin receptor signaling pathway TNF signaling pathway

Cytokine-cytokine receptor interaction TGF-beta signaling pathway Hippo signaling pathway Thermogenesis +1 more

Protein processing in endoplasmic reticulum Phagosome Efferocytosis Antigen processing and presentation Chagas disease Human cytomegalovirus infection Human T-cell leukemia virus 1 infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection ER-Phagosome pathway Assembly of Viral Components at the Budding Site Scavenging by Class A Receptors Scavenging by Class F Receptors ATF6 (ATF6-alpha) activates chaperone genes Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC +14 more

Tryptophan metabolism Glyoxylate and dicarboxylate metabolism Metabolic pathways Carbon metabolism FoxO signaling pathway Peroxisome Longevity regulating pathway Longevity regulating pathway - multiple species Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Chemical carcinogenesis - reactive oxygen species Detoxification of Reactive Oxygen Species Neutrophil degranulation Peroxisomal protein import +11 more

Endocrine resistance FoxO signaling pathway Cell cycle p53 signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Cellular senescence Wnt signaling pathway Hedgehog signaling pathway Apelin signaling pathway Hippo signaling pathway Focal adhesion Tight junction JAK-STAT signaling pathway Prolactin signaling pathway Thyroid hormone signaling pathway Oxytocin signaling pathway AGE-RAGE signaling pathway in diabetic complications Cushing syndrome Alcoholic liver disease Hepatitis C Measles Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Pathways in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Colorectal cancer Pancreatic cancer Endometrial cancer Glioma Prostate cancer Thyroid cancer Melanoma Bladder cancer Chronic myeloid leukemia Acute myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Viral myocarditis SCF(Skp2)-mediated degradation of p27/p21 RMTs methylate histone arginines Interleukin-4 and Interleukin-13 signaling Cyclin D associated events in G1 Ubiquitin-dependent degradation of Cyclin D PTK6 Regulates Cell Cycle Transcriptional Regulation by VENTX Transcriptional regulation by RUNX2 Regulation of RUNX1 Expression and Activity RUNX3 regulates WNT signaling RUNX3 regulates p14-ARF Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling +58 more

FoxO signaling pathway Cell cycle p53 signaling pathway PI3K-Akt signaling pathway Cellular senescence Wnt signaling pathway Hedgehog signaling pathway Hippo signaling pathway Focal adhesion JAK-STAT signaling pathway Prolactin signaling pathway Measles Human papillomavirus infection Human T-cell leukemia virus 1 infection Epstein-Barr virus infection Pathways in cancer Transcriptional misregulation in cancer Viral carcinogenesis MicroRNAs in cancer Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity +18 more

TP53 Regulates Transcription of DNA Repair Genes