Pathways column key: KEGG Reactome

Disease Term	Disease ID	Gene Symbol	Classification	References	Source	Pathways
DIABETES MELLITUS	EFO_0000400 C0011849 MESH:D003920	FTO	Unknown	27790247 37106081 38965376 39024449 39789286	GWAS catalog	Reversal of alkylation damage by DNA dioxygenases
		G6PD	Unknown	—	Disgenet	Pentose phosphate pathway Glutathione metabolism Metabolic pathways +5 more
		GATAD2A	Unknown	39024449	GWAS catalog	ATP-dependent chromatin remodeling HDACs deacetylate histones Regulation of TP53 Activity through Acetylation +2 more
		GCKR	Unknown	27790247 39024449	GWAS catalog	Regulation of Glucokinase by Glucokinase Regulatory Protein Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
		GIPR	Unknown	39024449	Disgenet, GWAS catalog	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +3 more
		GLIS3	Unknown	38965376 39024449	GWAS catalog	—
		GLP1R	Unknown	39024449	GWAS catalog	cAMP signaling pathway Neuroactive ligand-receptor interaction Hormone signaling +5 more
		GPR139	Unknown	38965376	GWAS catalog	—
		GPSM1	Unknown	39024449	GWAS catalog	Cocaine addiction G alpha (i) signalling events
		GRB14	Unknown	37106081 39024449	GWAS catalog	Tie2 Signaling
		GRHL1	Unknown	27790247	GWAS catalog	PPARA activates gene expression
		GSTM1	Unknown	—	Disgenet	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +10 more
		GSTT1	Unknown	—	Disgenet	Glutathione metabolism Metabolism of xenobiotics by cytochrome P450 Drug metabolism - cytochrome P450 +10 more
		GTF2IRD2	Unknown	39024449	GWAS catalog	—
		H2BC3	Unknown	38965376	GWAS catalog	Neutrophil extracellular trap formation Alcoholism Viral carcinogenesis +31 more
		HAPLN4	Unknown	39024449	GWAS catalog	—
		HCN1	Unknown	39024449	GWAS catalog	GnRH secretion HCN channels
		HERPUD1	Unknown	27790247	GWAS catalog	Protein processing in endoplasmic reticulum ATF4 activates genes in response to endoplasmic reticulum stress
		HFE	Unknown	—	Disgenet	TGF-beta signaling pathway Transferrin endocytosis and recycling
		HHEX	Unknown	38965376 39024449	GWAS catalog	Maturity onset diabetes of the young Transcriptional misregulation in cancer
		HK1	Unknown	39024449	GWAS catalog	Glycolysis / Gluconeogenesis Fructose and mannose metabolism Galactose metabolism +14 more
		HLA-C	Unknown	37106081	GWAS catalog	Endocytosis Phagosome Cellular senescence +24 more
		HLA-DQA1	Unknown	39024449 39789286	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DQA2	Unknown	37106081	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DQB1	Unknown	39024449 39789286	GWAS catalog	Phagosome Cell adhesion molecules Antigen processing and presentation +28 more
		HLA-DQB3	Unknown	39789286	GWAS catalog	—
		HMG20A	Unknown	39024449	GWAS catalog	—
		HMGA2	Unknown	39024449	GWAS catalog	Transcriptional misregulation in cancer MicroRNAs in cancer Formation of Senescence-Associated Heterochromatin Foci (SAHF)
		HMGCR	Unknown	27790247	Disgenet, GWAS catalog	Terpenoid backbone biosynthesis Metabolic pathways AMPK signaling pathway +5 more
		HNF1B	Unknown	37106081 38965376 39024449 39789286	Disgenet, GWAS catalog	Maturity onset diabetes of the young
		HNF4A	Unknown	37106081	GWAS catalog	AMPK signaling pathway Maturity onset diabetes of the young Nuclear Receptor transcription pathway
		IDE	Unknown	37106081	GWAS catalog	Virion - Herpesvirus Alzheimer disease Ub-specific processing proteases +1 more
		IGF2BP1	Unknown	39024449	GWAS catalog	MicroRNAs in cancer Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA MAPK6/MAPK4 signaling
		IGF2BP2	Unknown	37106081 38965376 39024449 39789286	GWAS catalog	Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
		IL6	Unknown	—	Disgenet	EGFR tyrosine kinase inhibitor resistance Antifolate resistance Cytokine-cytokine receptor interaction +59 more
		INS-IGF2	Unknown	—	Disgenet	—
		INSR	Unknown	—	Disgenet	MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway +26 more
		IRS1	Unknown	10591678	CTD, Disgenet	cGMP-PKG signaling pathway FoxO signaling pathway Hormone signaling +30 more
		ITGA2	Unknown	—	Disgenet	Virion - Rotavirus Phagosome PI3K-Akt signaling pathway +18 more
		ITPK1	Unknown	27790247	GWAS catalog	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system +3 more
		JAZF1	Unknown	37106081 38965376 39024449 39789286	GWAS catalog	—
		KAT5	Unknown	39024449	GWAS catalog	ATP-dependent chromatin remodeling Spinocerebellar ataxia Human T-cell leukemia virus 1 infection +15 more
		KCNQ1	Unknown	37106081 37601966 38965376 39024449 40465716	GWAS catalog	Adrenergic signaling in cardiomyocytes Cholinergic synapse Gastric acid secretion +6 more
		KCNU1	Unknown	39024449	GWAS catalog	cGMP-PKG signaling pathway Vascular smooth muscle contraction Insulin secretion +1 more
		KIAA1755	Unknown	38965376	GWAS catalog	—
		KIF11	Unknown	37601966	GWAS catalog	Motor proteins MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic +1 more
		KIF1A	Unknown	23776493	CTD, Disgenet	Motor proteins COPI-dependent Golgi-to-ER retrograde traffic Kinesins
		KIF5B	Unknown	23776493	CTD, Disgenet	Endocytosis Dopaminergic synapse Motor proteins +12 more
		KL	Unknown	39024449	GWAS catalog	Pentose and glucuronate interconversions Ascorbate and aldarate metabolism Metabolic pathways +15 more
		KLF11	Unknown	—	Disgenet	—

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Diabetes mellitus

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