Desbuquois syndrome

DNA replication Cell cycle Activation of ATR in response to replication stress Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state +4 more

Lysine degradation Metabolic pathways MAPK signaling pathway Pathways in cancer Chronic myeloid leukemia PKMTs methylate histone lysines Regulation of PTEN gene transcription +4 more

Hedgehog signaling pathway

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Calcium signaling pathway PI3K-Akt signaling pathway Axon guidance Focal adhesion Adherens junction Bacterial invasion of epithelial cells Epithelial cell signaling in Helicobacter pylori infection Malaria Pathways in cancer Transcriptional misregulation in cancer Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - reactive oxygen species Renal cell carcinoma Melanoma Non-small cell lung cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer PIP3 activates AKT signaling Constitutive Signaling by Aberrant PI3K in Cancer Sema4D mediated inhibition of cell attachment and migration RAF/MAP kinase cascade MET Receptor Activation Negative regulation of MET activity PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates RAS signaling MET activates PI3K/AKT signaling MET activates PTPN11 MET activates PTK2 signaling InlB-mediated entry of Listeria monocytogenes into host cell MET interacts with TNS proteins MET activates RAP1 and RAC1 MET receptor recycling MET activates STAT3 MECP2 regulates neuronal receptors and channels +37 more

Hedgehog 'off' state Anchoring of the basal body to the plasma membrane

IL-17 signaling pathway Relaxin signaling pathway Parathyroid hormone synthesis, secretion and action Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures RUNX2 regulates genes involved in cell migration +5 more

TNF signaling pathway GnRH signaling pathway Parathyroid hormone synthesis, secretion and action Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases +3 more

Endocrine resistance Leukocyte transendothelial migration GnRH signaling pathway Estrogen signaling pathway Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Pathways in cancer Proteoglycans in cancer Bladder cancer Diabetic cardiomyopathy Fluid shear stress and atherosclerosis Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling +15 more

Endocrine resistance IL-17 signaling pathway TNF signaling pathway Leukocyte transendothelial migration Estrogen signaling pathway Relaxin signaling pathway Hepatitis B Pathways in cancer Transcriptional misregulation in cancer Proteoglycans in cancer MicroRNAs in cancer Prostate cancer Bladder cancer Diabetic cardiomyopathy Lipid and atherosclerosis Fluid shear stress and atherosclerosis Signaling by SCF-KIT Collagen degradation Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures EPH-ephrin mediated repulsion of cells Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation Extra-nuclear estrogen signaling +22 more

Maturity onset diabetes of the young

MAPK signaling pathway Ras signaling pathway Rap1 signaling pathway Phospholipase D signaling pathway Mitophagy - animal Autophagy - animal Cellular senescence Apelin signaling pathway C-type lectin receptor signaling pathway Regulation of actin cytoskeleton Proteoglycans in cancer +8 more

Human T-cell leukemia virus 1 infection

Cysteine and methionine metabolism Metabolic pathways Methionine salvage pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation +1 more

Transcriptional misregulation in cancer

Motor proteins Cytoskeleton in muscle cells Striated Muscle Contraction

Motor proteins

Nicotinate and nicotinamide metabolism Metabolic pathways Biosynthesis of cofactors Nicotinate metabolism +1 more

Glycosaminoglycan degradation Metabolic pathways Lysosome HS-GAG degradation MPS IIIB - Sanfilippo syndrome B +2 more

Biosynthesis of various nucleotide sugars Metabolic pathways Biosynthesis of nucleotide sugars Sialic acid metabolism +1 more

COPI-dependent Golgi-to-ER retrograde traffic

Activation of NIMA Kinases NEK9, NEK6, NEK7 Nuclear Pore Complex (NPC) Disassembly EML4 and NUDC in mitotic spindle formation

Other glycan degradation Sphingolipid metabolism Metabolic pathways Lysosome Glycosphingolipid metabolism Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation +5 more

EGFR tyrosine kinase inhibitor resistance MAPK signaling pathway Ras signaling pathway Regulation of RAS by GAPs RAS signaling downstream of NF1 loss-of-function variants +2 more

Cell cycle Cohesin Loading onto Chromatin

Necroptosis NOD-like receptor signaling pathway Cytosolic DNA-sensing pathway C-type lectin receptor signaling pathway Pathogenic Escherichia coli infection Shigellosis Salmonella infection Pertussis Yersinia infection Influenza A Coronavirus disease - COVID-19 Lipid and atherosclerosis Metalloprotease DUBs The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection +12 more

Nicotinate and nicotinamide metabolism Metabolic pathways Biosynthesis of cofactors Nicotinate metabolism +1 more

TGF-beta signaling pathway Signaling by BMP

Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation Thyroid hormone signaling pathway Prion disease Human papillomavirus infection Pathways in cancer MicroRNAs in cancer Breast cancer Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi NOTCH1 Intracellular Domain Regulates Transcription Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Constitutive Signaling by NOTCH1 HD Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway Defective LFNG causes SCDO3 RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription +20 more

Endocrine resistance Notch signaling pathway Th1 and Th2 cell differentiation Thyroid hormone signaling pathway Human papillomavirus infection Pathways in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Breast cancer Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi NOTCH2 intracellular domain regulates transcription NOTCH2 Activation and Transmission of Signal to the Nucleus Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH4 Intracellular Domain Regulates Transcription +13 more

cGMP-PKG signaling pathway Hormone signaling Vascular smooth muscle contraction Fluid shear stress and atherosclerosis Physiological factors +2 more

Purine metabolism Metabolic pathways cGMP-PKG signaling pathway Hormone signaling Vascular smooth muscle contraction Oxytocin signaling pathway Physiological factors +4 more

Hormone signaling

EGFR tyrosine kinase inhibitor resistance Endocrine resistance MAPK signaling pathway ErbB signaling pathway Ras signaling pathway Rap1 signaling pathway Chemokine signaling pathway FoxO signaling pathway Sphingolipid signaling pathway Phospholipase D signaling pathway Mitophagy - animal Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway Apoptosis Longevity regulating pathway Longevity regulating pathway - multiple species Cellular senescence Axon guidance VEGF signaling pathway Apelin signaling pathway Gap junction Signaling pathways regulating pluripotency of stem cells C-type lectin receptor signaling pathway Natural killer cell mediated cytotoxicity T cell receptor signaling pathway B cell receptor signaling pathway Fc epsilon RI signaling pathway Thermogenesis Long-term potentiation Neurotrophin signaling pathway Cholinergic synapse Serotonergic synapse Long-term depression Regulation of actin cytoskeleton Insulin signaling pathway GnRH signaling pathway Estrogen signaling pathway Melanogenesis Prolactin signaling pathway Thyroid hormone signaling pathway Oxytocin signaling pathway Relaxin signaling pathway GnRH secretion AGE-RAGE signaling pathway in diabetic complications Growth hormone synthesis, secretion and action Alzheimer disease Pathways of neurodegeneration - multiple diseases Alcoholism Hepatitis C Hepatitis B Human cytomegalovirus infection Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Human immunodeficiency virus 1 infection Pathways in cancer Viral carcinogenesis Proteoglycans in cancer MicroRNAs in cancer Chemical carcinogenesis - receptor activation Chemical carcinogenesis - reactive oxygen species Colorectal cancer Renal cell carcinoma Endometrial cancer Glioma Prostate cancer Thyroid cancer Melanoma Bladder cancer Chronic myeloid leukemia Acute myeloid leukemia Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Lipid and atherosclerosis Activation of RAS in B cells Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB4 signaling Signaling by SCF-KIT p38MAPK events GRB2 events in EGFR signaling SHC1 events in EGFR signaling Downstream signal transduction GRB2 events in ERBB2 signaling Tie2 Signaling EGFR Transactivation by Gastrin DAP12 signaling FCERI mediated MAPK activation NCAM signaling for neurite out-growth VEGFR2 mediated cell proliferation CD209 (DC-SIGN) signaling Constitutive Signaling by EGFRvIII SHC-mediated cascade:FGFR1 FRS-mediated FGFR1 signaling SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Regulation of RAS by GAPs RAF activation RAF/MAP kinase cascade MAP2K and MAPK activation Negative regulation of MAPK pathway Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions RAS signaling downstream of NF1 loss-of-function variants Paradoxical activation of RAF signaling by kinase inactive BRAF PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases MET activates RAS signaling Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer FLT3 Signaling Constitutive Signaling by Overexpressed ERBB2 Estrogen-stimulated signaling through PRKCZ RAS GTPase cycle mutants Signaling downstream of RAS mutants Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants +130 more

Lysine degradation Metabolic pathways PKMTs methylate histone lysines

Lysine degradation Metabolic pathways Transcriptional misregulation in cancer PKMTs methylate histone lysines Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint +5 more

Steroid biosynthesis Metabolic pathways Cholesterol biosynthesis

SUMOylation of DNA damage response and repair proteins

Neddylation

Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Hedgehog 'off' state Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 +5 more

Cell cycle Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex G1/S-Specific Transcription +6 more